Polymyositis and dermatomyositis diagnostic study of choice: Difference between revisions
| Line 5: | Line 5: | ||
== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
* [[Muscle biopsy]] is the gold standard test for the diagnosis of polymyositis and dermatomyositis. | * [[Muscle biopsy]] is the gold standard test for the diagnosis of polymyositis and dermatomyositis.<ref name="BohanPeter1975">{{cite journal|last1=Bohan|first1=Anthony|last2=Peter|first2=James B.|title=Polymyositis and Dermatomyositis|journal=New England Journal of Medicine|volume=292|issue=8|year=1975|pages=403–407|issn=0028-4793|doi=10.1056/NEJM197502202920807}}</ref> | ||
* The following result of [[muscle biopsy]] is confirmatory of polymyositis and dermatomyositis: | * The following result of [[muscle biopsy]] is confirmatory of polymyositis and dermatomyositis: | ||
** | ** Necrosis | ||
** | ** Phagocytosis | ||
** Regenerative activity reflected by basophilia, large, vesicular nuclei and prominent nucleoli | |||
** Atrophy and degeneration of both Type I and II fibers, especially in a perifascicular distribution | |||
** Internal migration of nuclei | |||
** Vacuolization | |||
** Fiber-size variation | |||
** Mononuclear inflammatory infiltrate, often most prominent in a perivascular location | |||
** Increase in endomysial and perimysial connective tissue | |||
* The [[muscle biopsy]] should be performed when: | * The [[muscle biopsy]] should be performed when: | ||
** The patient presented with symptoms of [[muscle weakness]] and [[skin rash]] | ** The patient presented with symptoms of [[muscle weakness]] and [[skin rash]] | ||
Revision as of 16:21, 5 April 2018
|
Polymyositis and dermatomyositis Microchapters |
|
Differentiating Polymyositis and dermatomyositis from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Polymyositis and dermatomyositis diagnostic study of choice On the Web |
|
American Roentgen Ray Society Images of Polymyositis and dermatomyositis diagnostic study of choice |
|
FDA on Polymyositis and dermatomyositis diagnostic study of choice |
|
CDC on Polymyositis and dermatomyositis diagnostic study of choice |
|
Polymyositis and dermatomyositis diagnostic study of choice in the news |
|
Blogs on Polymyositis and dermatomyositis diagnostic study of choice |
|
Risk calculators and risk factors for Polymyositis and dermatomyositis diagnostic study of choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Diagnostic Study of Choice
- Muscle biopsy is the gold standard test for the diagnosis of polymyositis and dermatomyositis.[1]
- The following result of muscle biopsy is confirmatory of polymyositis and dermatomyositis:
- Necrosis
- Phagocytosis
- Regenerative activity reflected by basophilia, large, vesicular nuclei and prominent nucleoli
- Atrophy and degeneration of both Type I and II fibers, especially in a perifascicular distribution
- Internal migration of nuclei
- Vacuolization
- Fiber-size variation
- Mononuclear inflammatory infiltrate, often most prominent in a perivascular location
- Increase in endomysial and perimysial connective tissue
- The muscle biopsy should be performed when:
- The patient presented with symptoms of muscle weakness and skin rash
- An elevated level of muscle enzymes is detected in the patient.
References
- ↑ Bohan, Anthony; Peter, James B. (1975). "Polymyositis and Dermatomyositis". New England Journal of Medicine. 292 (8): 403–407. doi:10.1056/NEJM197502202920807. ISSN 0028-4793.