Sjögren's syndrome medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Pharmacologic medical therapies for dry eye, dry mouth, and other sicca symptom of Sjögren's syndrome are Pilocarpine, Cevimeline and artifical tears.

Medical Therapy

• Pharmacologic medical therapies for dry eye, dry mouth, and other sicca symptom of Sjögren's syndrome include:
  • Preferred regimen (1): Pilocarpine 5 mg PO q8h
  • Preferred regimen (2): Cevimeline 30 mg PO q8h
  • Preferred regimen (3): artificial tears
• Pharmacologic medical therapies for organ-based disease and constitutional symptoms of Sjögren's syndrome include:
  • Preferred regimen (1): Hydroxychloroquine 200 mg PO q24h
  • Preferred regimen (2): Methotrexate 0.2 mg/kg weekly
  • Preferred regimen (3): Leflunomide 20 mg/day
  • Preferred regimen (4): Azathioprine 3 to 5 mg/kg once daily
  • Preferred regimen (5): Sulfasalazine 30 mg PO q8h
  • Preferred regimen (6): Cyclosporine 5 mg/kg/day
  • Preferred regimen (7): Cyclophosphamide 50-100 mg/m²/day
  • Preferred regimen (8): Rituximab 375 mg/m2 once weekly for 4 doses