Reactive arthritis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Laboratory findings consistent with the diagnosis of reactive arthritis include elevated ESR, elevated C-reactive protein [CRP], and elevated TLC showing increased PMNs. Synovial fluid or synovial membrane biopsy for detection of bacterial DNA by PCR or immunofluorescence microscopy.

Laboratory Findings

Laboratory findings consistent with the diagnosis of reactive arthritis include:

• Elevated ESR
• Elevated C-reactive protein [CRP]
• Elevated TLC showing increased PMNs
• Synovial fluid analysis to determine cell count, culture, glucose, and presence of crystals.
• Diagnostic lab evaluations include testing for HLA-B27, PCR or ELISA for reactive arthritis associated microorganisms.
  • Laboratory evaluations required to establish infection with reactive arthritis causing organisms include routine urine exam, culture of stool and urethra.
  • Synovial fluid or synovial membrane biopsy for detection of bacterial DNA by PCR or immunofluorescence microscopy.
  • IgA antibodies to specific bacterial antigens
• Other test include tuberculin skin test and HIV.

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