Small-sized vessel vasculitis: Difference between revisions

Revision as of 15:22, 10 April 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.

			Symptoms					Physical examination			Lab Findings				Imaging				Histopathology
Diseases			Clinical manifestations								Para-clinical findings									Gold standard	Additional findings
			Symptoms					Physical examination			Para-clinical findings
			Headache	Fever	Weight loss	Arthralgia	Claudication	Bruit	HTN	Focal neurological disorder	Biomarker	CBC	ESR	Other	CT scan	Angiography	Ultrasound/ Echocardiography	Other	Histopathology
Small-Vessel Vasculitis	ANCA-associated vasculitis	Microscopic polyangiitis^[1]	+	-	-	+/-	-	-	-	+	Anti-PR3 antibody (C-ANCA) (40%), Anti-MPO antibody (P-ANCA) (60%)	Leukocytosis, Normocytic anemia	↑	Proteinuria, Erythrocyte casts	Suspected pancreatitis	Mesenteric angiography for differentiating from polyarteritis nodosa	-	Bilateral nodular, and patchy opacities in CXR	Glomerulonephritis with focal necrosis, crescent formation, and lack or paucity of immunoglobulin deposits	Histological confirmation	Rash, Hemoptysis
		Granulomatosis with polyangiitis (Wegener’s)^[2]	+	+/-	+/-	-	-	-	-	+	Anti-PR3 antibody (C-ANCA) (90%), Anti-MPO antibody (P-ANCA) (10%)	Leukocytosis, Normochromic normocytic anemia	↑	↑Cr or BUN, Hypoalbuminemia	Consolidation, Patchy or diffuse ground-glass opacities	Occlusion or stenosis of LAD and RCA in coronary angiography	-	Single or multiple nodules and masses with cavitation in CXR	Parenchymal necrosis, Granulomatous inflammation	Histological confirmation	Conjunctivitis, Episcleritis, Uveitis, Optic nerve vasculitis
		Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)^[3]	+/-	-	-	+	-	-	-	+	Anti-MPO antibody (P-ANCA) (40%), Eotaxin-3	Eosinophilia, Anemia	↑	↑Cr or BUN, Proteinuria, Erythrocyte casts, ↑IgE levels	Significant enlargement of peripheral pulmonary arteries	Myocardial ischemia and infarction in coronary angiography	Congestive heart failure (CHF) in echocardiography	Extensive air-space opacities in CXR	Small necrotizing granulomas with eosinophilic core surrounded by macrophages and epithelioid giant cells	Histological confirmation	Allergic rhinitis, Asthma, Urticarial rash
		Hydralazine-associated ANCA-associated vasculitis^[4]	-	-	-	+	-	-	-	+/-	Anti-MPO antibody (P-ANCA), Anti-histone antibodies	Anemia	-	↑Cr or BUN, Hypoalbuminemia	Bilateral pulmonary infiltrates	Aneurysms or occlusions of the visceral arteries	-	-	Pauci-immune necrotizing and crescentic glomerulonephritis	Histological confirmation	Sinusitis, Hemoptysis
	Immune complex small-vessel vasculitis	Anti-glomerular basement membrane disease^[5]	+	+/-	-	-	-	-	+	-	Anti-GBM antibodies	Hypochromic microcytic anemia, Thrombocytopenia	-	↓C3 level	Pulmonary hemorrhage	-	Normal kidneys	Alveolar infiltrates spreading from the hilum in CXR	Cellular crescents in the glomeruli, Intra-alveolar hemorrhages	Anti-GBM antibodies	Hemoptysis, Hematuria
		Cryoglobulinemic vasculitis^[6]	+/-	+/-	-	+	+/-	-	-	-	C4 component	Leukocytosis, Anemia	↑	ANA, hypocomplementemia	R/O underlying malignancy	Stenosis or occlusions of the visceral arteries	Bacterial endocarditis in echocardiography	Interstitial involvement or pleural effusions in CXR	HCV-associated proteins in vasculitic skin, Intraluminal cryoglobulin deposits	Histological confirmation	Acrocyanosis, Retinal hemorrhage, Purpura
		Hepatitis C virus-associated cryoglobulinemic vasculitis^[7]	+/-	+/-	+	+	-	-	+	+/-	HCV RNA, Cryoglobulins	Leukocytosis, Anemia	↑	↓Serum C4, Positive RF	Increased hepatic echogenicity	-	Hepatomegaly, Splenomegaly	Increased hepatic echogenicity in MRI	Vasculitic skin, Antigen infilteration in lesions	HCV RNA, Histological confirmation	Palpable purpura, Microscopic hematuria
		IgA vasculitis (Henoch-Schönlein purpura)^[8]	-	-	+	+	-	-	-	-	IgA	Normochromic anemia, Leukocytosis	↑	Stool OB, ↓C3, ↓C4	-	-	Increased bowel wall thickness, hematomas, peritoneal fluid, and intussusception	Dilated loops of bowel consistent in abdominal X-ray	Leukocytoclastic vasculitis in postcapillary venules with IgA deposition	History and physical examination	Hematuria, Palpable purpura
		Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)^[9]	-	-	+/-	+	-	-	-	-	C1q	Mild anemia	↑	ANA, ↓C1q, ↓C3, ↓C4	-	-	Hepatomegaly, Splenomegaly	-	Deposits of immunoglobulins, complement, or fibrin around blood vessels	Urticaria, Histological confirmation	Urticaria, Hematuria
	Gastrointestinal disease	Acute mesenteric ischemia^[10]	-	+/-	-	-	-	-	-	-	I-FABP, Alpha-GST, Ischemia-modified albumin (IMA)	Leukocytosis, ↑HCT	-	↑Amylase	Bowel wall thickening, Intestinal pneumatosis, Portomesenteric thrombosis	Mesenteric venous thrombosis	Arterial stenosis or occlusion of the celiac or superior mesenteric arteries in duplex ultrasound	Ileus with distended loops of bowel, Bowel wall thickening in abdominal X-ray	Superficial mucosal hemorrhage, edema and necrosis	History and physical examination	Abdominal pain, Distension, Absent bowel sounds
	Cardiovascular disease	Infective Endocarditis^[11]	+	+	+	-	-	-	-	+	NT-proBNP	Normochromic-normocytic anemia	↑	Hyperglobulinemia, Cryoglobulinemia	Metastatic infections, such as splenic infarct, renal infarcts, or psoas abscess	-	Vegetation, abscess, or new dehiscence of a prosthetic valvein echocardiography	Vertebral osteomyelitis in MRI	Vegetation or intracardiac abscess demonstrating active endocarditis	Echocardiography (TTE)	Janeway lesions, Osler nodes, Roth spots, Vertebral osteomyelitis
	Cardiovascular disease	Leukocytoclastic Vasculitis^[12]	+	-	-	+	-	-	-	+	IgM, IgA, IgG	Leukocytosis, Anemia	↑	Hypocomplementemia	-	Vascular stenosis and obstruction in visceral angiography	-	-	Perivascular inflammatory infiltrate of neutrophils with leukocytoclasia (releasing nuclear debris)	Histological confirmation	Palpable purpura, Petechiae
	Pulmonary disease	Langerhans Cell Histiocytosis^[13]	+/-	-	-	+	-	-	-	-	CD1a, CD207,BRAF-V600E	Anemia	↑	Hypercalcemia	Pulmonary cysts and nodules, Bone lytic lesions	-	Hepatomegaly, Splenomegaly	Cerebellum and pons hyperintensity in MRI	Birbeck granules by electron microscopy	Histological confirmation	Brown to purplish papules, Eczematous rash
		Non-Small Cell Lung Cancer^[14]	-	+/-	+	-	-	-	-	+/-	EGFR, ROS1, EML4-ALK, PD-L1	Leukocytosis, Anemia	↑	Hypercalcemia, Hyponatremia	Pulmonary lesion or mass	-	Pulmonary marginal lesions	Staging and response to treatment in PET-CT	Adenocarcinoma, Squamous cell carcinoma	High resolution CT-scan	Cough, Hemoptysis
		Small Cell Lung Cancer^[15]	-	+/-	+	-	-	-	-	+/-	p53, Thyroid transcription factor-1 (TTF1)	Anemia	↑	Hyponatremia	Large hilar mass with bulky mediastinal adenopathy	-	Endobronchial ultrasound (EBUS)	Standard staging	Spindled cells with dark nuclei, scant cytoplasm, and fine, granular nuclear chromatin	High resolution CT-scan	Cough, Hemoptysis
		Pulmonary Infarction^[16]	+/-	-	-	-	-	-	+	-	D-dimer	Mild leukocytosis, Mild anemia	-	Hypoxemia, Hypocarbia or Hypercarbia, Respiratory alkalosis	Pulmonary embolism	Low-density filling defect within the pulmonary artery	Pericardial effusion in echocardiography	Pulmonary infiltrates, atelectasis, and pleural effusions in CXR	Infarct induced apoptosis	Pulmonary artery angiography	Cough, Hemoptysis
	Renal disease	Acute Poststreptococcal Glomerulonephritis^[17]	-	-	-	+	-	-	+	+/-	Antistreptolysin-O (ASO) titers	Leukocytosis	↑	Hypocomplementemia	-	-	Normal to slightly enlarged kidneys	Central venous congestion in a hilar pattern in CXR	Hypercellularity of endothelial and mesangial cells, Infiltration of the glomerular tuft with polymorphonuclear cells	Histological confirmation	Hematuria
	Hematologic disease	Hemolytic-Uremic Syndrome^[18]	+	+	-	+	-	-	+	+	C5b-9, ADAMTS13	Anemia, Thrombocytopenia, Reticulocytosis	↑	↑Lactate dehydrogenase (LDH), Hypercalcemia	Thalami, brainstem, or cerebellum abnormality	Cerebral microangiopathy or hypertension	Hypoechoic kidney	Abnormal hyperintensity in the brain cisterns in MRI	Microthromboses include fibrin thrombi that may occlude the glomerular tuft	Clinical findings coupled with laboratory abnormalities	Hematuria, Proteinuria
		Chronic Lymphocytic Leukemia (CLL)^[19]	+	+	+	+	+/-	-	-	+/-	CD5, CD19, CD20, IgV_H	Absolute lymphocytosis, Smudge cells	↑	Flow cytometry	Staging	-	-	-	Large atypical cells, cleaved cells, and prolymphocytes	Chromosomal and genetic testing	Easy bruising
		Multiple Myeloma^[20]	+	-	+	+	+	+	+/-	+/-	Ig light chain	Anemia, Thrombocytopenia, Leukopenia	↑	Bone marrow aspiration and biopsy, ↑Cr	Osseous involvement and lytic lesions	Peripheral zone of increased vascularity in lesions	-	Punched-out lesion in skull X-ray	Clonal proliferation of plasma cells	Protein electrophoresis plus conventional X-rays	Constipation
		Hypereosinophilic Syndrome^[21]	+/-	+/-	-	-	-	-	-	-	IgE, CD117 with CD2	Eosinophilia	-	↑Serum tryptase	Lymphadenopathy and splenomegaly	-	Intracardiac thrombi in echocardiography	-	Reticulin stain for myelofibrosis and tryptase staining for mast cells	Clinical findings coupled with laboratory abnormalities	Splinter hemorrhages, Raynaud phenomenon
		Non-Hodgkin Lymphoma^[22]	+	+	+	+	+/-	+/-	+/-	+/-	MYC, BCL2, BCL6, and TP53	Lymphocytosis, Anemia, Thrombocytopenia	↑	↑Lactate dehydrogenase (LDH), Hypercalcemia	Enlarged lymph nodes, Hepatosplenomegaly, Filling defects in the liver and spleen	-	Hepatosplenomegaly	Mediastinal lymphadenopathy	Small cleaved or noncleaved, intermediate, or large cell with a follicular or diffuse pattern	Surgically excised tissue biopsy	Easy bruising, Testicular mass, Skin lesion
		Serum Sickness^[23]	+	+	-	+/-	+/-	-	-	+/-	IL-1, IL-6, TNF	Leukopenia	↑	Polyclonal gammopathy, ↑Cr, Cryoglobulinemia	-	-	-	-	Arteritic lesions are focal, necrotizing, and inflammatory involving all layers of the artery	Clinical findings coupled with laboratory abnormalities	Hematuria, Skin rash
		Disseminated Intravascular Coagulation^[24]	+/-	+	-	+/-	-	-	+	+	Fibrin degradation product (FDP)	Thrombocytopenia, Schistocytes	↑	↑D-dimer, aPTT and PT	Intracranial hemorrhage	-	-	-	Ischemia and necrosis due to fibrin deposition in small and medium-sized vessels	Clinical findings coupled with laboratory abnormalities	Acral cyanosis, Hemorrhagic skin infarctions
		Idiopathic Thrombocytopenic Purpura^[25]	+	+/-	-	+	-	-	-	+	FC gamma receptors (FCGR) IIb	Anemia, Thrombocytopenia	-	HIV, ANA	R/O other causes	-	R/O splenomegaly	-	Increased number of normal morphologic megakaryocytes	Clinical findings coupled with thrombocytopenia	Easy bruising, Purpura
	Systemic disease	Sarcoidosis^[26]	+	+	+	+	-	-	-	+/-	IL-2 and IFN-γ	Mild anemia	↑	↑ACE, ↑1, 25-dihydroxyvitamin D	Active alveolitis or fibrosis	-	Hepatosplenomegaly	Bilateral hilar adenopathy	Noncaseating granulomas (NCGs)	Histological confirmation	Heart block, Ocular lesion
		Legionella Infection^[27]	+	+	+	+	-	-	-	+/-	Inflammatory cytokines	Leukocytosis with left shift, Thrombocytosis	↑	↑D-dimer, FDP, Hyponatremia	Pleural effusion	-	-	Nonspecific and indistinguishable CXR	Intra-alveolar inflammation, Microabscesses in the parenchyma	Sputum culture	Cough, Diarrhea
		Systemic lupus erythematosus^[28]	+	+	+	+	-	-	+	+	Anti dsDNA, ANA	Leukopenia, Lymphopenia, Anemia, Thrombocytopenia	↑	↑Cr or BUN, ↑ALT or AST, Proteinuria	Interstitial lung disease, Pneumonitis, Pulmonary emboli, Alveolar hemorrhage	Aneurysms	Pericardial effusion, pulmonary hypertension, or verrucous Libman-Sacks endocarditis in echocardiography	Central nervous system (CNS) lupus white-matter changes in MRI	Staging lupus nephritis	Anti-dsDNA antibody test	Skin rashes or photosensitivity
		Rheumatoid arthritis^[29]	-	-	+	+	+	+	-	-	RF, Anti-CCP antibody	Anemia	↑	↑Cr or BUN, ↑ALT or AST, ANA	Microfractures	Aneurysms	Effusions in joints	Basilar invagination with cranial migration of an eroded odontoid peg in MRI	Influx of inflammatory cells into the synovial membrane, with angiogenesis, proliferation of chronic inflammatory cells	Clinical findings coupled anti-CCP antibody	Rheumatoid nodules
		Relapsing polychondritis^[30]	-	+/-	+/-	+	+	-	-	-	-	Leukocytosis, Anemia	-	Cryoglobulins, ANA, C-ANCA	Calcification of cartilaginous structures	Aortic root dilatation	Aortic root dilatation and degree of aortic regurgitation in echocardiography	Tracheal stenosis in CXR	Chondrolysis, Chondritis, Perichondritis	Clinical findings coupled with imaging	Ear pain and redness, Polyarthritis
Diseases			Headache	Fever	Weight loss	Arthralgia	Claudication	Bruit	HTN	Focal neurological disorder	Biomarker	CBC	ESR	Other	CT scan	Angiography	Ultrasound/ Echocardiography	Other	Histopathology	Gold standard	Additional findings
Variable-vessel vasculitis	Behçet’s syndrome^[31]		-	-	-	+	-	-	+/-	-	CXCL1	Mild anemia, Neutrophilia	↑	Factor V Leiden	Focal CNS lesions	Aneurysm formation and thrombosis areas	Valve vegetations and ventricular thrombi in echocardiography	Meningoencephalitis in MRI	Lymphocytic and plasma cell invasion in the prickle cell layer of the epidermis	Clinical criteria	Genital ulcerations, Oral ulceration
	Cogan's syndrome^[32]		+/-	-	-	+/-	-	-	-	+	Anti-Hsp70 antibodies	Anemia, Thrombocytosis	↑	RF, ANA	Thickening and enhancement of both posterior sclera	Stenosis, thrombosis or more lesions in aortic root	Aortic insufficiency in echocardiography	Early interstitial keratitis by slit lamp	Muscle necrosis and atrophy resembling myositis	-	Red eye, Hearing loss, Vertigo
	Gastrointestinal disease	Inflammatory Bowel Disease^[33]	+/-	+	+	+	+	-	-	-	Anti-Saccharomyces cerevisiae antibody (ASCA), P-ANCA	Leukocytosis, Anemia	↑	Iron or vitamin deficiency, Stool OB	Mesenteric fat stranding, bowel wall enhancement, increased vascularity (comb sign)	-	Fistulas, Abscesses, Stenosis	Grossly denuded mucosa with active bleeding in colonoscopy	Crypt abscesses and mucosal ulceration, Granulomas	Endoscopy	GI bleeding
		Whipple's disease^[34]	+	+/-	+	+	+	+	+	+	CCR6, Gut-homing marker integrin β7-chain, T whippelii DNA	Mild anemia, Neutrophilia	↑	72-hour fecal fat determination	Nonspecific malabsorption	-	Hepatosplenomegaly	-	Periodic acid-Schiff–positive macrophages infiltration in lamina propria of the small bowel	Broad-spectrum PCR amplifications	Cachexia, Glossitis
		Sjögren's syndrome^[35]	-	-	+/-	+	-	-	-	-	Anti-Ro and Anti-La, Anti-alpha-fodrin antibody	Anemia, Leukopenia, Eosinophilia	↑	Hypergammaglobulinemia, Low bicarbonate level, Hypokalemia	Salt and pepper or honeycomb appearance in parotid glands	-	Multicystic or reticular pattern in atrophic salivary gland	R/O obstructions or strictures with Sialography	Focal aggregates of lymphocytes	Schirmer test	Keratoconjunctivitis, Gingival inflammation
Single-organ vasculitis	Primary central nervous system vasculitis^[36]		+	+	+	-	+	-	+	+	von Willebrand factor antigen (vWF)	Normal	-	CSF pleocytosis, predominantly lymphocytes	Cerebral infarcts or hemorrhages with mass effect, or hydrocephalus	Aneurysm in circle of Willis	-	Progression of the disease or response to therapy in MRI	Chronic granulomatous inflammation and giant cells	Histological confirmation	Skin rash, Purpura
	Infectious disease	Aspergillosis^[37]	+	+	+	-	-	-	-	+	Aspergillus nucleic acid in blood, Galactomannan	Eosinophilia	↑	↑Serum IgE	Aspergilloma mass within a cavity	Mass effect stenosis	-	Aspergilloma mass within the brain in MRI	Septate hyphae, branching at acute angles, and tissue necrosis with granulomata and blood vessel invasion	Histological confirmation	Hemoptysis, Aspergilloma
		Histoplasmosis^[38]	+	+	+	+	+	-	-	+	-	Mild anemia	↑	↑ALP, ↑LDH	Cerebral histoplasmosis	-	Valvular involvement in echocardiography	PFT	Presence of yeast forms in tissue through hematoxylin and eosin staining	Sputum cultures	Pneumonia, Mediastinitis
		Herpes Simplex Encephalitis^[39]	+	+	-	-	-	-	-	+	HSV DNA	Mild lymphocytosis	↑	CSF pleocytosis	Low-density lesions in the temporal and/or frontal lobe	-	-	Hemorrhagic lesion in white matter	Multinuclear giant cells	PCR or brain biopsy	Seizures, Vomiting
	Systemic disease	Eclampsia^[40]	+	+	-	+	-	-	+	+	VEGF, PlGF, Soluble FLT-1	Anemia, Thrombocytopenia, Schistocytes	-	↑Bilirubin, ↓Haptoglobin, ↑LDH, ↑Cr	Cortical hypodense areas in the occipital lobes, Diffuse cerebral edema	-	Poor fetal growth, Oligohydramnios, Abnormal umbilical artery	Increased signal at the gray-white matter junction in MRI	-	24-hour urine study	Seizure, Edema
	Systemic disease	Fibromuscular dysplasia^[41]	+	-	+/-	+	+	+	+	+/-	Transforming growth factor β (TGF-β)	Normal	↑	↑ Cr or BUN	Alternating stenosis and dilatations in CT angiography	Stenosis in the renal arteries	Luminal narrowing alternating with dilatation (Beads sign)	Focal concentric, long-segment tubular stenosis or outpouching in MRA	Fibrodysplastic changes, Collagen deposition	Digital subtraction angiography (DSA)	Spontaneous coronary artery dissection (SCAD)

References

↑ Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.
↑ Kubaisi B, Abu Samra K, Foster CS (2016). "Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations". Intractable Rare Dis Res. 5 (2): 61–9. doi:10.5582/irdr.2016.01014. PMC 4869584. PMID 27195187.
↑ Keogh KA, Specks U (April 2006). "Churg-Strauss syndrome". Semin Respir Crit Care Med. 27 (2): 148–57. doi:10.1055/s-2006-939518. PMID 16612766.
↑ Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW (2013). "Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report". J Med Case Rep. 7: 20. doi:10.1186/1752-1947-7-20. PMC 3565908. PMID 23316942.
↑ McAdoo SP, Pusey CD (July 2017). "Anti-Glomerular Basement Membrane Disease". Clin J Am Soc Nephrol. 12 (7): 1162–1172. doi:10.2215/CJN.01380217. PMID 28515156.
↑ Ferri C, Mascia MT (January 2006). "Cryoglobulinemic vasculitis". Curr Opin Rheumatol. 18 (1): 54–63. PMID 16344620.
↑ Guo QY, Wu M, Wang YW, Sun GD (2017). "Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report". Exp Ther Med. 14 (2): 1395–1398. doi:10.3892/etm.2017.4671. PMC 5525644. PMID 28810602.
↑ Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK (December 2015). "IgA vasculitis (Henoch-Schönlein purpura)". Dermatol. Online J. 21 (12). PMID 26990342.
↑ Buck A, Christensen J, McCarty M (2012). "Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review". J Clin Aesthet Dermatol. 5 (1): 36–46. PMC 3277093. PMID 22328958.
↑ Sise MJ (February 2014). "Acute mesenteric ischemia". Surg. Clin. North Am. 94 (1): 165–81. doi:10.1016/j.suc.2013.10.012. PMID 24267504.
↑ McDonald JR (2009). "Acute infective endocarditis". Infect Dis Clin North Am. 23 (3): 643–64. doi:10.1016/j.idc.2009.04.013. PMC 2726828. PMID 19665088.
↑ Einhorn J, Levis JT (2015). "Dermatologic Diagnosis: Leukocytoclastic Vasculitis". Perm J. 19 (3): 77–8. doi:10.7812/TPP/15-001. PMC 4500485. PMID 26176572.
↑ Margo CE, Goldman DR (2008). "Langerhans cell histiocytosis". Surv Ophthalmol. 53 (4): 332–58. doi:10.1016/j.survophthal.2008.04.007. PMID 18572052.
↑ Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008). "Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship". Mayo Clin Proc. 83 (5): 584–94. doi:10.4065/83.5.584. PMC 2718421. PMID 18452692.
↑ Jackman DM, Johnson BE (2005). "Small-cell lung cancer". Lancet. 366 (9494): 1385–96. doi:10.1016/S0140-6736(05)67569-1. PMID 16226617.
↑ Parambil JG, Savci CD, Tazelaar HD, Ryu JH (April 2005). "Causes and presenting features of pulmonary infarctions in 43 cases identified by surgical lung biopsy". Chest. 127 (4): 1178–83. doi:10.1378/chest.127.4.1178. PMID 15821192.
↑ VanDeVoorde RG (January 2015). "Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis". Pediatr Rev. 36 (1): 3–12, quiz 13. doi:10.1542/pir.36-1-3. PMID 25554106.
↑ Corrigan JJ, Boineau FG (November 2001). "Hemolytic-uremic syndrome". Pediatr Rev. 22 (11): 365–9. PMID 11691946.
↑ Byrd JC, Stilgenbauer S, Flinn IW (2004). "Chronic lymphocytic leukemia". Hematology Am Soc Hematol Educ Program: 163–83. doi:10.1182/asheducation-2004.1.163. PMID 15561682.
↑ Michels TC, Petersen KE (March 2017). "Multiple Myeloma: Diagnosis and Treatment". Am Fam Physician. 95 (6): 373–383. PMID 28318212.
↑ Klion A (2009). "Hypereosinophilic syndrome: current approach to diagnosis and treatment". Annu. Rev. Med. 60: 293–306. doi:10.1146/annurev.med.60.062107.090340. PMID 19630574.
↑ Shankland KR, Armitage JO, Hancock BW (September 2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.
↑ Lin RY (January 1986). "Serum sickness syndrome". Am Fam Physician. 33 (1): 157–62. PMID 2867672.
↑ Venugopal A (2014). "Disseminated intravascular coagulation". Indian J Anaesth. 58 (5): 603–8. doi:10.4103/0019-5049.144666. PMC 4260307. PMID 25535423.
↑ Nomura S (2016). "Advances in Diagnosis and Treatments for Immune Thrombocytopenia". Clin Med Insights Blood Disord. 9: 15–22. doi:10.4137/CMBD.S39643. PMC 4948655. PMID 27441004.
↑ Chiarchiaro J, Chen BB, Gibson KF (2016). "New molecular targets for the treatment of sarcoidosis". Curr Opin Pulm Med. 22 (5): 515–21. doi:10.1097/MCP.0000000000000304. PMC 5152532. PMID 27454074.
↑ Murdoch DR (January 2003). "Diagnosis of Legionella infection". Clin. Infect. Dis. 36 (1): 64–9. doi:10.1086/345529. PMID 12491204.
↑ Tsokos, George C. (2011). "Systemic Lupus Erythematosus". New England Journal of Medicine. 365 (22): 2110–2121. doi:10.1056/NEJMra1100359. ISSN 0028-4793.
↑ Scott JT (1991). "The gold standard in rheumatoid arthritis". J R Soc Med. 84 (9): 513–4. PMC 1293405. PMID 1682491.
↑ Emmungil H, Aydın SZ (2015). "Relapsing polychondritis". Eur J Rheumatol. 2 (4): 155–159. doi:10.5152/eurjrheum.2015.0036. PMC 5047229. PMID 27708954.
↑ Yazici H, Fresko I, Yurdakul S (March 2007). "Behçet's syndrome: disease manifestations, management, and advances in treatment". Nat Clin Pract Rheumatol. 3 (3): 148–55. doi:10.1038/ncprheum0436. PMID 17334337.
↑ Iliescu DA, Timaru CM, Batras M, De Simone A, Stefan C (2015). "COGAN'S SYNDROME". Rom J Ophthalmol. 59 (1): 6–13. PMC 5729811. PMID 27373108.
↑ Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF (2016). "Inflammatory Bowel Disease". Dtsch Arztebl Int. 113 (5): 72–82. doi:10.3238/arztebl.2016.0072. PMC 4782273. PMID 26900160.
↑ Dutly F, Altwegg M (2001). "Whipple's disease and "Tropheryma whippelii"". Clin Microbiol Rev. 14 (3): 561–83. doi:10.1128/CMR.14.3.561-583.2001. PMC 88990. PMID 11432814.
↑ Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T (2017). "The Diagnosis and Treatment of Sjögren's Syndrome". Dtsch Arztebl Int. 114 (20): 354–361. doi:10.3238/arztebl.2017.0354. PMC 5471601. PMID 28610655.
↑ Benseler SM, Silverman E, Aviv RI, Schneider R, Armstrong D, Tyrrell PN, deVeber G (April 2006). "Primary central nervous system vasculitis in children". Arthritis Rheum. 54 (4): 1291–7. doi:10.1002/art.21766. PMID 16575852.
↑ Latgé JP (1999). "Aspergillus fumigatus and aspergillosis". Clin Microbiol Rev. 12 (2): 310–50. PMC 88920. PMID 10194462.
↑ Guimarães AJ, Nosanchuk JD, Zancopé-Oliveira RM (2006). "DIAGNOSIS OF HISTOPLASMOSIS". Braz J Microbiol. 37 (1): 1–13. doi:10.1590/S1517-83822006000100001. PMC 2863343. PMID 20445761.
↑ Sköldenberg B (1996). "Herpes simplex encephalitis". Scand J Infect Dis Suppl. 100: 8–13. PMID 9163027.
↑ Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM (2011). "Pre-eclampsia: pathophysiology, diagnosis, and management". Vasc Health Risk Manag. 7: 467–74. doi:10.2147/VHRM.S20181. PMC 3148420. PMID 21822394.
↑ Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X (2007). "Fibromuscular dysplasia". Orphanet J Rare Dis. 2: 28. doi:10.1186/1750-1172-2-28. PMC 1899482. PMID 17555581.

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[pmid20688249-1] Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.

[pmid27195187-2] Kubaisi B, Abu Samra K, Foster CS (2016). "Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations". Intractable Rare Dis Res. 5 (2): 61–9. doi:10.5582/irdr.2016.01014. PMC 4869584. PMID 27195187.

[pmid16612766-3] Keogh KA, Specks U (April 2006). "Churg-Strauss syndrome". Semin Respir Crit Care Med. 27 (2): 148–57. doi:10.1055/s-2006-939518. PMID 16612766.

[pmid23316942-4] Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW (2013). "Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report". J Med Case Rep. 7: 20. doi:10.1186/1752-1947-7-20. PMC 3565908. PMID 23316942.

[pmid28515156-5] McAdoo SP, Pusey CD (July 2017). "Anti-Glomerular Basement Membrane Disease". Clin J Am Soc Nephrol. 12 (7): 1162–1172. doi:10.2215/CJN.01380217. PMID 28515156.

[pmid16344620-6] Ferri C, Mascia MT (January 2006). "Cryoglobulinemic vasculitis". Curr Opin Rheumatol. 18 (1): 54–63. PMID 16344620.

[pmid28810602-7] Guo QY, Wu M, Wang YW, Sun GD (2017). "Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report". Exp Ther Med. 14 (2): 1395–1398. doi:10.3892/etm.2017.4671. PMC 5525644. PMID 28810602.

[pmid26990342-8] Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK (December 2015). "IgA vasculitis (Henoch-Schönlein purpura)". Dermatol. Online J. 21 (12). PMID 26990342.

[pmid22328958-9] Buck A, Christensen J, McCarty M (2012). "Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review". J Clin Aesthet Dermatol. 5 (1): 36–46. PMC 3277093. PMID 22328958.

[pmid24267504-10] Sise MJ (February 2014). "Acute mesenteric ischemia". Surg. Clin. North Am. 94 (1): 165–81. doi:10.1016/j.suc.2013.10.012. PMID 24267504.

[pmid19665088-11] McDonald JR (2009). "Acute infective endocarditis". Infect Dis Clin North Am. 23 (3): 643–64. doi:10.1016/j.idc.2009.04.013. PMC 2726828. PMID 19665088.

[pmid26176572-12] Einhorn J, Levis JT (2015). "Dermatologic Diagnosis: Leukocytoclastic Vasculitis". Perm J. 19 (3): 77–8. doi:10.7812/TPP/15-001. PMC 4500485. PMID 26176572.

[pmid18572052-13] Margo CE, Goldman DR (2008). "Langerhans cell histiocytosis". Surv Ophthalmol. 53 (4): 332–58. doi:10.1016/j.survophthal.2008.04.007. PMID 18572052.

[pmid18452692-14] Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008). "Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship". Mayo Clin Proc. 83 (5): 584–94. doi:10.4065/83.5.584. PMC 2718421. PMID 18452692.

[pmid16226617-15] Jackman DM, Johnson BE (2005). "Small-cell lung cancer". Lancet. 366 (9494): 1385–96. doi:10.1016/S0140-6736(05)67569-1. PMID 16226617.

[pmid15821192-16] Parambil JG, Savci CD, Tazelaar HD, Ryu JH (April 2005). "Causes and presenting features of pulmonary infarctions in 43 cases identified by surgical lung biopsy". Chest. 127 (4): 1178–83. doi:10.1378/chest.127.4.1178. PMID 15821192.

[pmid25554106-17] VanDeVoorde RG (January 2015). "Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis". Pediatr Rev. 36 (1): 3–12, quiz 13. doi:10.1542/pir.36-1-3. PMID 25554106.

[pmid11691946-18] Corrigan JJ, Boineau FG (November 2001). "Hemolytic-uremic syndrome". Pediatr Rev. 22 (11): 365–9. PMID 11691946.

[pmid15561682-19] Byrd JC, Stilgenbauer S, Flinn IW (2004). "Chronic lymphocytic leukemia". Hematology Am Soc Hematol Educ Program: 163–83. doi:10.1182/asheducation-2004.1.163. PMID 15561682.

[pmid28318212-20] Michels TC, Petersen KE (March 2017). "Multiple Myeloma: Diagnosis and Treatment". Am Fam Physician. 95 (6): 373–383. PMID 28318212.

[pmid19630574-21] Klion A (2009). "Hypereosinophilic syndrome: current approach to diagnosis and treatment". Annu. Rev. Med. 60: 293–306. doi:10.1146/annurev.med.60.062107.090340. PMID 19630574.

[pmid22835603-22] Shankland KR, Armitage JO, Hancock BW (September 2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.

[pmid2867672-23] Lin RY (January 1986). "Serum sickness syndrome". Am Fam Physician. 33 (1): 157–62. PMID 2867672.

[pmid25535423-24] Venugopal A (2014). "Disseminated intravascular coagulation". Indian J Anaesth. 58 (5): 603–8. doi:10.4103/0019-5049.144666. PMC 4260307. PMID 25535423.

[pmid27441004-25] Nomura S (2016). "Advances in Diagnosis and Treatments for Immune Thrombocytopenia". Clin Med Insights Blood Disord. 9: 15–22. doi:10.4137/CMBD.S39643. PMC 4948655. PMID 27441004.

[pmid27454074-26] Chiarchiaro J, Chen BB, Gibson KF (2016). "New molecular targets for the treatment of sarcoidosis". Curr Opin Pulm Med. 22 (5): 515–21. doi:10.1097/MCP.0000000000000304. PMC 5152532. PMID 27454074.

[pmid12491204-27] Murdoch DR (January 2003). "Diagnosis of Legionella infection". Clin. Infect. Dis. 36 (1): 64–9. doi:10.1086/345529. PMID 12491204.

[Tsokos2011-28] Tsokos, George C. (2011). "Systemic Lupus Erythematosus". New England Journal of Medicine. 365 (22): 2110–2121. doi:10.1056/NEJMra1100359. ISSN 0028-4793.

[pmid16824912-29] Scott JT (1991). "The gold standard in rheumatoid arthritis". J R Soc Med. 84 (9): 513–4. PMC 1293405. PMID 1682491.

[pmid27708954-30] Emmungil H, Aydın SZ (2015). "Relapsing polychondritis". Eur J Rheumatol. 2 (4): 155–159. doi:10.5152/eurjrheum.2015.0036. PMC 5047229. PMID 27708954.

[pmid17334337-31] Yazici H, Fresko I, Yurdakul S (March 2007). "Behçet's syndrome: disease manifestations, management, and advances in treatment". Nat Clin Pract Rheumatol. 3 (3): 148–55. doi:10.1038/ncprheum0436. PMID 17334337.

[pmid27373108-32] Iliescu DA, Timaru CM, Batras M, De Simone A, Stefan C (2015). "COGAN'S SYNDROME". Rom J Ophthalmol. 59 (1): 6–13. PMC 5729811. PMID 27373108.

[pmid26900160-33] Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF (2016). "Inflammatory Bowel Disease". Dtsch Arztebl Int. 113 (5): 72–82. doi:10.3238/arztebl.2016.0072. PMC 4782273. PMID 26900160.

[pmid11432814-34] Dutly F, Altwegg M (2001). "Whipple's disease and "Tropheryma whippelii"". Clin Microbiol Rev. 14 (3): 561–83. doi:10.1128/CMR.14.3.561-583.2001. PMC 88990. PMID 11432814.

[pmid28610655-35] Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T (2017). "The Diagnosis and Treatment of Sjögren's Syndrome". Dtsch Arztebl Int. 114 (20): 354–361. doi:10.3238/arztebl.2017.0354. PMC 5471601. PMID 28610655.

[pmid16575852-36] Benseler SM, Silverman E, Aviv RI, Schneider R, Armstrong D, Tyrrell PN, deVeber G (April 2006). "Primary central nervous system vasculitis in children". Arthritis Rheum. 54 (4): 1291–7. doi:10.1002/art.21766. PMID 16575852.

[pmid10194462-37] Latgé JP (1999). "Aspergillus fumigatus and aspergillosis". Clin Microbiol Rev. 12 (2): 310–50. PMC 88920. PMID 10194462.

[pmid20445761-38] Guimarães AJ, Nosanchuk JD, Zancopé-Oliveira RM (2006). "DIAGNOSIS OF HISTOPLASMOSIS". Braz J Microbiol. 37 (1): 1–13. doi:10.1590/S1517-83822006000100001. PMC 2863343. PMID 20445761.

[pmid9163027-39] Sköldenberg B (1996). "Herpes simplex encephalitis". Scand J Infect Dis Suppl. 100: 8–13. PMID 9163027.

[pmid21822394-40] Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM (2011). "Pre-eclampsia: pathophysiology, diagnosis, and management". Vasc Health Risk Manag. 7: 467–74. doi:10.2147/VHRM.S20181. PMC 3148420. PMID 21822394.

[pmid17555581-41] Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X (2007). "Fibromuscular dysplasia". Orphanet J Rare Dis. 2: 28. doi:10.1186/1750-1172-2-28. PMC 1899482. PMID 17555581.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

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@@ Line 34: / Line 34: @@
 ! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
 ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-|-
-! rowspan="9" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Large-Vessel Vasculitis
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Takayasu arteritis]]<ref name="pmid23626437">{{cite journal| author=Vaideeswar P, Deshpande JR| title=Pathology of Takayasu arteritis: A brief review. | journal=Ann Pediatr Cardiol | year= 2013 | volume= 6 | issue= 1 | pages= 52-8 | pmid=23626437 | doi=10.4103/0974-2069.107235 | pmc=3634248 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23626437  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[MMP|MMP-3]] and [[Matrix metalloproteinase|MMP-9]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm|Aneurysmal dilatation]] of the [[aorta]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Blood vessel]] [[stenosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Circumferential thickening of the [[arterial]] wall (Macaroni sign)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PET scan|PET-scan]], [[Cardiac]] [[CT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granulomatous]] [[inflammation]] of [[arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Arteriography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary aneurysm]]
-|-
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Giant cell arteritis]]<ref name="pmid13679546">{{cite journal| author=Calvo-Romero JM| title=Giant cell arteritis. | journal=Postgrad Med J | year= 2003 | volume= 79 | issue= 935 | pages= 511-5 | pmid=13679546 | doi= | pmc=1742823 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13679546  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pentraxin|Pentraxin 3 (PTX3)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]], [[Occlusion]], [[Dilatation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysm]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mural [[inflammation]] in [[Magnetic resonance angiography|MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granulomatous]] [[inflammation]] of [[arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Jaw pain]] and [[Jaw claudication|claudication]]
-|-
-! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurological disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cerebral aneurysm]]<ref name="pmid20557771">{{cite journal| author=Stafa A, Leonardi M| title=Role of neuroradiology in evaluating cerebral aneurysms. | journal=Interv Neuroradiol | year= 2008 | volume= 14 Suppl 1 | issue=  | pages= 23-37 | pmid=20557771 | doi=10.1177/15910199080140S106 | pmc=3328052 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20557771  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Well-defined round, slightly hyperattenuating lesion
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bulging out of the [[Lumen|main lumen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heterogeneous]] signal intensity in [[Magnetic resonance angiography|MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Layers of [[smooth muscle cells]], Intact [[endothelium]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Nausea]], [[Vomiting]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurofibromatosis type 1]]<ref name="pmid28512424">{{cite journal| author=Cassiman C, Casteels I, Stalmans P, Legius E, Jacob J| title=Optical Coherence Tomography Angiography of Retinal Microvascular Changes Overlying Choroidal Nodules in Neurofibromatosis Type 1. | journal=Case Rep Ophthalmol | year= 2017 | volume= 8 | issue= 1 | pages= 214-220 | pmid=28512424 | doi=10.1159/000469702 | pmc=5422752 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28512424  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NF1|NF1 mutated gene]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Neurofibromin|Neurofibromin gene]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone disease|Bone abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Optical coherence tomography angiography (OCTA)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Optic nerve gliomas]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Elongated spindle-shaped [[cells]] in [[Neurofibroma|neurofibromas]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[National Institutes of Health|NIH]] [[diagnostic criteria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Café au lait spot|Cafe au Lait spot]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Neurofibromatosis type 2]]<ref name="Evans2000">{{cite journal|last1=Evans|first1=D G. R|title=Neurofibromatosis type 2|journal=Journal of Medical Genetics|volume=37|issue=12|year=2000|pages=897–904|issn=14686244|doi=10.1136/jmg.37.12.897}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NF2 gene|NF2 mutated gene]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Merlin (protein)|Schwannomin]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Meningioma]], [[Schwannoma]], [[Ependymoma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fluorescein angiography]] showed [[retinal]] [[hamartoma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Localized [[schwannomas]] in nerve [[ultrasound]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Schwannoma]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Encapsulated biphasic [[nerve sheath]] [[tumor]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[National Institutes of Health|NIH]] [[diagnostic criteria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hearing loss]], [[Vision loss]]
-|-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581">{{cite journal| author=Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X| title=Fibromuscular dysplasia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 28 | pmid=17555581 | doi=10.1186/1750-1172-2-28 | pmc=1899482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17555581  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Transforming growth factor β|Transforming growth factor β (TGF-β)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[stenosis]] and [[Dilatation|dilatations]] in [[CT angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] in the [[renal arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Luminal narrowing alternating with [[dilatation]] (Beads sign)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal [[concentric]], long-segment [[tubular]] [[stenosis]] or outpouching in [[MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Fibrodysplastic changes, [[Collagen]] deposition
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Digital subtraction angiography|Digital subtraction angiography (DSA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Spontaneous coronary artery dissection|Spontaneous coronary artery dissection (SCAD)]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Ehlers-Danlos syndrome]]<ref name="pmid27824552">{{cite journal| author=Gazit Y, Jacob G, Grahame R| title=Ehlers-Danlos Syndrome-Hypermobility Type: A Much Neglected Multisystemic Disorder. | journal=Rambam Maimonides Med J | year= 2016 | volume= 7 | issue= 4 | pages=  | pmid=27824552 | doi=10.5041/RMMJ.10261 | pmc=5101008 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27824552  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[TGF-β]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cultured skin [[fibroblasts]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multiple [[vascular]] segments with [[aneurysms]] and [[dissections]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Dissection]] of the [[Circumflex branch of left coronary artery|posterolateral branch of the left circumflex coronary artery (LCx)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Visceral]] [[arteries]] abnormality
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular anomaly|Vascular abnormalities]] in [[MRA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Thin and rare [[collagen]] bundles in the [[dermis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bleeding]], [[Easy bruising|Bruisability]], [[Heart murmur]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Polymyalgia rheumatica|Polymyalgia rheumatica (PMR)]]<ref name="pmid18390527">{{cite journal| author=Michet CJ, Matteson EL| title=Polymyalgia rheumatica. | journal=BMJ | year= 2008 | volume= 336 | issue= 7647 | pages= 765-9 | pmid=18390527 | doi=10.1136/bmj.39514.653588.80 | pmc=2287267 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18390527  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fibrinogen|Plasma fibrinogen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normocytic normochromic anemia|Normocytic, normochromic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CRP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Odontoid process|Periodontoid]] localization of [[calcification]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vessel wall]] thickening, Increased mural contrast enhancement
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Subacromial bursitis|Subacromial]] or subdeltoid [[bursitis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |High [[Fluorescein sodium|F-FDG]] accumulation around the [[joints]] in [[Positron emission tomography|FDG PET-CT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small angular fibers, [[Pyknosis|Pyknotic]] [[nuclear]] clumps, or target-targetoid fibers
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Joint stiffness]], [[Fatigue]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Amyloidosis]]<ref name="pmid23227278">{{cite journal| author=Baker KR, Rice L| title=The amyloidoses: clinical features, diagnosis and treatment. | journal=Methodist Debakey Cardiovasc J | year= 2012 | volume= 8 | issue= 3 | pages= 3-7 | pmid=23227278 | doi= | pmc=3487569 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23227278  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Immunoglobulin light chains|Immunoglobulin light chain]][[Amyloid beta|(Amyloid)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑ [[ALT]] or [[AST]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Diffusely hypoattenuating and enlarged [[liver]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Amyloid]] deposition in the media and [[adventitia]] of small arteries
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Solid organs increased [[echogenicity]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Tc-DPD for [[cardiac]] '''[[amyloid]]''' deposits
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Extracellular]] deposition of [[Fibrillarin|fibrillar proteins]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Biopsy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cardiomegaly]], [[Dyspnea]]
-|-
-! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
-! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
-! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
-|-
-! rowspan="18" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Medium-Vessel Vasculitis
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Polyarteritis nodosa]]<ref name="pmid25770638">{{cite journal| author=Howard T, Ahmad K, Swanson JA, Misra S| title=Polyarteritis nodosa. | journal=Tech Vasc Interv Radiol | year= 2014 | volume= 17 | issue= 4 | pages= 247-51 | pmid=25770638 | doi=10.1053/j.tvir.2014.11.005 | pmc=4363102 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25770638  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[LAMP2|LAMP-2 protein autoantibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia]], [[Thrombocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑ [[ALT]] or [[AST]], [[Proteinuria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal regions of [[infarction]] or [[hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Multiple [[Aneurysm|microaneurysms]],  [[Hemorrhage]] due to focal [[rupture]], [[Occlusion]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] and [[renal]] [[arteriovenous fistula]] in [[Doppler sonography|color Doppler sonography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotizing]] [[inflammatory]] lesions
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Sudden [[weight loss]], [[Abdominal pain]]
-|-
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis B virus]]-associated [[polyarteritis nodosa]]<ref name="pmid25755502">{{cite journal |vauthors=Sharma A, Sharma K |title=Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis |journal=J Clin Exp Hepatol |volume=3 |issue=3 |pages=204–12 |date=September 2013 |pmid=25755502 |pmc=4216827 |doi=10.1016/j.jceh.2013.06.001 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis B surface antigen|HBsAg]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia]], [[Thrombocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ [[ALT]] or [[AST]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Focal regions of [[infarction]] or [[hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms|Microaneurysms]] in [[mesenteric artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] and [[renal]] [[arteriovenous fistula]] in [[Doppler sonography|color Doppler sonography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotizing]] [[inflammatory]] lesions
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Peripheral neuropathy]], [[Livedo reticularis]]
-|-
-! colspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Kawasaki disease]]<ref name="pmid21447126">{{cite journal| author=Takahashi K, Oharaseki T, Yokouchi Y| title=Pathogenesis of Kawasaki disease. | journal=Clin Exp Immunol | year= 2011 | volume= 164 Suppl 1 | issue=  | pages= 20-2 | pmid=21447126 | doi=10.1111/j.1365-2249.2011.04361.x | pmc=3095860 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21447126  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NT-proBNP]], [[Meprin A]], [[Filamin A interacting protein 1 like|Filamin C]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia]], ↑[[WBC]] with a [[left shift]], [[Thrombocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acute phase reactant|Acute-phase reactants]], ↓[[Cholesterol]], ↓[[HDL]], ↓[[Apolipoprotein A1|ApolipoA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary artery]] [[Calcification|calcifications]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary artery aneurysm|Coronary artery aneurysms]], [[Coronary artery stenosis|stenosis]] or [[Coronary artery anomaly|occlusion]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Coronary artery anomaly]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Electron beam tomography|Electron beam CT (EBCT)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Acute destruction of the [[Tunica media|media]] by [[neutrophils]], with loss of [[elastic fibers]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Diarrhea]], [[Vomiting]]
-|-
-! rowspan="10" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infectious disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Parvovirus B19 infection]]<ref name="pmid12097253">{{cite journal| author=Heegaard ED, Brown KE| title=Human parvovirus B19. | journal=Clin Microbiol Rev | year= 2002 | volume= 15 | issue= 3 | pages= 485-505 | pmid=12097253 | doi= | pmc=118081 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12097253  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parvovirus B19|B19]] [[DNA]], ↓[[Reticulocyte count]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |anti–[[parvovirus B19]] [[IgM]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hydrops]] in fetal [[ultrasonography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parvovirus B19|B19]] [[DNA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Purpura|Purpuric rash]], [[Erythema multiforme]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Scarlet fever]]<ref name="pmid29081840">{{cite journal| author=Basetti S, Hodgson J, Rawson TM, Majeed A| title=Scarlet fever: a guide for general practitioners. | journal=London J Prim Care (Abingdon) | year= 2017 | volume= 9 | issue= 5 | pages= 77-79 | pmid=29081840 | doi=10.1080/17571472.2017.1365677 | pmc=5649319 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29081840  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antistreptococcal antibodies|Antistreptolysin-O (ASO) titers]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[CRP]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Thickened [[pulmonary]] markings if [[pneumonia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Sparse [[Neutropenia|neutrophilic]] [[Perivascular cell|perivascular infiltrate]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Sand-paper rashes, [[Sore throat]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Toxic shock syndrome]]<ref name="pmid22180682">{{cite journal| author=Vostral SL| title=Rely and Toxic Shock Syndrome: a technological health crisis. | journal=Yale J Biol Med | year= 2011 | volume= 84 | issue= 4 | pages= 447-59 | pmid=22180682 | doi= | pmc=3238331 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22180682  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Procalcitonin]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myoglobinuria]], [[Pyuria|Sterile pyuria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acute respiratory distress syndrome]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrosis|Necrolysis]] of [[keratinocytes]] in [[epidermis]],  Perivascular [[lymphocytic]] infiltrate
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical criteria
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Peeling or [[rashes]], Organ dysfunction
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Mononucleosis]]<ref name="pmid25774295">{{cite journal| author=Balfour HH, Dunmire SK, Hogquist KA| title=Infectious mononucleosis. | journal=Clin Transl Immunology | year= 2015 | volume= 4 | issue= 2 | pages= e33 | pmid=25774295 | doi=10.1038/cti.2015.1 | pmc=4346501 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25774295  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Epstein Barr virus|EBV]] [[DNA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Atypical lymphocyte]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heterophile antibody test|Heterophile antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CNS Disease|CNS involvement]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Encephalitis]] in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphoproliferative response]] in [[oropharynx]], [[Lymphocytic|Lymphocytic infiltration]] in [[spleen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heterophile antibody test]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splenomegaly]], [[Palatal]] [[petechiae]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Leptospirosis]]<ref name="pmid11292640">{{cite journal |vauthors=Levett PN |title=Leptospirosis |journal=Clin. Microbiol. Rev. |volume=14 |issue=2 |pages=296–326 |date=April 2001 |pmid=11292640 |pmc=88975 |doi=10.1128/CMR.14.2.296-326.2001 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interleukin 6|IL-6]], [[IL-8]] and [[IL-10]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑[[ALT]] or [[AST]], [[Proteinuria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | Diffuse [[alveolar]] [[hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Toxin]]-mediated break down of [[endothelial cell]] membranes of [[capillaries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Culture and the [[Agglutination|microscopic agglutination test]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Red eyes]], [[Skin rash]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Lyme disease|Lyme Disease]]<ref name="pmid23319969">{{cite journal| author=Biesiada G, Czepiel J, Leśniak MR, Garlicki A, Mach T| title=Lyme disease: review. | journal=Arch Med Sci | year= 2012 | volume= 8 | issue= 6 | pages= 978-82 | pmid=23319969 | doi=10.5114/aoms.2012.30948 | pmc=3542482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23319969  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CXCL9|CXCL9 (MIG)]], [[CXCL10|CXCL10 (IP-10)]] and [[CCL19|CCL19 (MIP3B)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Microscopic hematuria]], [[Proteinuria]], ↑[[ALT]] or [[AST]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Punctate lesions in periventricular [[white matter]] in [[brain]] [[SPECT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acrodermatitis chronica atrophicans]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Serological testing|Serologic '''tests''']]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Erythema migrans]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Measles]]<ref name="pmid22510638">{{cite journal| author=White SJ, Boldt KL, Holditch SJ, Poland GA, Jacobson RM| title=Measles, mumps, and rubella. | journal=Clin Obstet Gynecol | year= 2012 | volume= 55 | issue= 2 | pages= 550-9 | pmid=22510638 | doi=10.1097/GRF.0b013e31824df256 | pmc=3334858 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22510638  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Measles]] [[Immunoglobulin M|IgM]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]], [[Lymphocytosis]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[ALT]] or [[AST]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pneumonia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Spongiosis and vesiculation in the [[epidermis]] with scattered dyskeratotic [[keratinocytes]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[PCR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash|Generalized rash]], [[Cough]], [[Coryza]], or [[Conjunctivitis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rocky Mountain Spotted Fever]]<ref name="pmid2504480">{{cite journal| author=Walker DH| title=Rocky Mountain spotted fever: a disease in need of microbiological concern. | journal=Clin Microbiol Rev | year= 1989 | volume= 2 | issue= 3 | pages= 227-40 | pmid=2504480 | doi= | pmc=358117 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2504480  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |''[[Rickettsia rickettsii infection|R rickettsii]]'' [[serology]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[ALT]] or [[AST]], [[Hyponatremia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Infarction]], [[edema]], and [[meningeal]] enhancement
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myocardial]] or conduction abnormalities in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Immunofluorescent]] or [[immunoperoxidase]] staining of ''[[Rickettsia rickettsii infection|R rickettsii]]''
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical criteria and [[tick]] exposure
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Rash on the [[Palms of the hands|palms]] and [[soles]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Staphylococcal scalded skin syndrome|Staphylococcal Scalded Skin Syndrome]]<ref name="pmid27651848">{{cite journal| author=Mishra AK, Yadav P, Mishra A| title=A Systemic Review on Staphylococcal Scalded Skin Syndrome (SSSS): A Rare and Critical Disease of Neonates. | journal=Open Microbiol J | year= 2016 | volume= 10 | issue=  | pages= 150-9 | pmid=27651848 | doi=10.2174/1874285801610010150 | pmc=5012080 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27651848  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anti exfoliatin and [[Alpha toxin|anti alpha-toxin antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Blood culture]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pneumonia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Epidermal bullosa simplex|Intraepidermal blister]], dense superficial perivascular lymphohistiocytic infiltrate
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Blood culture]] and clinical findings
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Erythroderma|'''Widespread''' skin erythema]], [[Blisters|fluid-filled '''blisters''']]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Toxic Epidermal Necrolysis]]<ref name="pmid27239294">{{cite journal| author=Hoetzenecker W, Mehra T, Saulite I, Glatz M, Schmid-Grendelmeier P, Guenova E et al.| title=Toxic epidermal necrolysis. | journal=F1000Res | year= 2016 | volume= 5 | issue=  | pages=  | pmid=27239294 | doi=10.12688/f1000research.7574.1 | pmc=4879934 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27239294  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[MicroRNA|MicroRNA-124]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normocytic normochromic anemia|Normochromic normocytic anemia]], [[Eosinophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fluid loss]] and [[electrolyte abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tracheobronchial]] [[inflammation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Necrotic]] [[keratinocytes]] with full-thickness [[epithelial]] [[necrosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology]] and clinical findings
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Erythematous rash|Erythematous macular rash]] with [[purpuric]] centers
-|-
-! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cardiovascular disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Atrial Myxoma]]<ref name="pmid8407260">{{cite journal |vauthors=MacGowan SW, Sidhu P, Aherne T, Luke D, Wood AE, Neligan MC, McGovern E |title=Atrial myxoma: national incidence, diagnosis and surgical management |journal=Ir J Med Sci |volume=162 |issue=6 |pages=223–6 |date=June 1993 |pmid=8407260 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Calretinin]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]], [[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Interleukin 6|IL-6]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Atrial]] filling defect larger than a [[thrombus]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tumor]] location, size, attachment, and mobility in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Size, shape, and surface characteristics in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lipid|Lipidic]] cells embedded in a [[vascular]] myxoid stroma
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Dyspnea on exertion]], [[Syncope]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cholesterol Embolism]]<ref name="pmid21886725">{{cite journal| author=Avci G, Akoz T, Gul AE| title=Cutaneous cholesterol embolization. | journal=J Dermatol Case Rep | year= 2009 | volume= 3 | issue= 2 | pages= 27-9 | pmid=21886725 | doi=10.3315/jdcr.2009.1031 | pmc=3157794 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21886725  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interleukin 5|IL-5]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]], [[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophiluria]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thoracic aorta|Thoracic]] and [[Abdominal aorta|abdominal aortic]] sources of [[embolism]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Atheroembolism]] in [[abdominal aorta]] and the [[lower extremity]] [[arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Excluding an [[intracardiac]] source of [[embolism]] with [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Birefringent]] crystals or biconvex needle-shaped ghostly clefts within the [[arterial]] [[lumen]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Livedo reticularis]],
-[[Ischemic|Ischemic patches]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Segmental arteries|Segmental arterial]] mediolysis<ref name="Chao2009">{{cite journal|last1=Chao|first1=Christine|title=Segmental Arterial Mediolysis|journal=Seminars in Interventional Radiology|volume=26|issue=03|year=2009|pages=224–232|issn=0739-9529|doi=10.1055/s-0029-1225666}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Visceral]] artery [[aneurysm]] in [[CT angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Alternating [[aneurysms]] and [[stenoses]] (beading)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Retroperitoneal hematoma]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Disruption of the [[smooth muscle]] in the [[Tunica media|media]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Angiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Ischemic colitis]]
-|-
-! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Antiphospholipid syndrome|Antiphospholipid Syndrome]]<ref name="pmid26637701">{{cite journal| author=Chaturvedi S, McCrae KR| title=The antiphospholipid syndrome: still an enigma. | journal=Hematology Am Soc Hematol Educ Program | year= 2015 | volume= 2015 | issue=  | pages= 53-60 | pmid=26637701 | doi=10.1182/asheducation-2015.1.53 | pmc=4877624 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26637701  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antiphospholipid antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Hemolytic anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lupus anticoagulant|Lupus anticoagulant (LA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stroke]],
-[[Pulmonary embolism]], [[Budd-Chiari syndrome]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombus]] in major [[vessels]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Valve thickening, vegetations, or  insufficiency in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Noninflammatory bland [[thrombosis]] without perivascular [[inflammation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hx of [[thrombosis]] and [[antiphospholipid antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Miscarriage]], [[Pulmonary hypertension]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Juvenile Idiopathic Arthritis]]<ref name="pmid22753788">{{cite journal |vauthors=Espinosa M, Gottlieb BS |title=Juvenile idiopathic arthritis |journal=Pediatr Rev |volume=33 |issue=7 |pages=303–13 |date=July 2012 |pmid=22753788 |doi=10.1542/pir.33-7-303 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid factor|Rheumatoid factor (RF)]], [[S100A12]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphocytosis]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Myeloid-related proteins 8/14 (MRP8/14)
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Synovial]] [[hypertrophy]], Joint effusions
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral vasculitis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Inflamed [[synovium]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone scan|Bone scanning]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular congestion]], [[Extravasation|RBC extravasation]], Venular lumen occlusion
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Conventional [[radiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash|Evanescent rash]], [[Dactylitis]]
-|-
-! colspan="3" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Headache
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |Fever
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Weight loss
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Arthralgia
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Claudication
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Bruit
-! colspan="1" rowspan="1" style="background:#4479BA; color: #FFFFFF;" align="center" |HTN
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Focal neurological disorder
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Biomarker
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CBC
-! style="background:#4479BA; color: #FFFFFF;" align="center" |ESR
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |CT scan
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Angiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Ultrasound/ Echocardiography
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Histopathology
-! style="background:#4479BA; color: #FFFFFF;" align="center" |'''Gold standard'''
-! style="background:#4479BA; color: #FFFFFF;" align="center" |Additional findings
 |-
 ! rowspan="30" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
@@ Line 1,261: / Line 638: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]], [[pulmonary hypertension]], or verrucous [[Libman-Sacks endocarditis]] in [[echocardiography]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central nervous system|Central nervous system (CNS)]] [[Systemic lupus erythematosus|lupus]] white-matter changes in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Staging [[lupus nephritis]]
+! align="center"  style="padding: 5px 5px; background: #F5F5F5;" |Staging [[lupus nephritis]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti-dsDNA antibody test]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rashes]] or [[photosensitivity]]
@@ Line 1,552: / Line 929: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Seizure]], [[Edema]]
 |-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581" />
+! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Fibromuscular dysplasia]]<ref name="pmid17555581">{{cite journal| author=Plouin PF, Perdu J, La Batide-Alanore A, Boutouyrie P, Gimenez-Roqueplo AP, Jeunemaitre X| title=Fibromuscular dysplasia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 28 | pmid=17555581 | doi=10.1186/1750-1172-2-28 | pmc=1899482 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17555581  }}</ref>
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-

Small-sized vessel vasculitis: Difference between revisions

Revision as of 15:22, 10 April 2018

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