Rheumatoid arthritis risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Common risk factors in the development of [[rheumatoid arthritis]] are the family history of [[RA]], cigarette [[smoking]], race like more prevalent in Native Americans, strongly associated with [[Major histocompatibility complex]] (MHC) class II antigen [[Human leukocyte antigen|HLA]]-DR4 and patient with silica and [[asbestos]] exposure. | Common risk factors in the development of [[rheumatoid arthritis]] are the family history of [[RA]], cigarette [[smoking]], race like more prevalent in Native Americans, strongly associated with [[Major histocompatibility complex]] (MHC) class II antigen [[Human leukocyte antigen|HLA]]-DR4 and patient with [[silica]] and [[asbestos]] exposure. | ||
Less common risk factors are [[obesity]] and high consumption of red meat. | Less common risk factors are [[obesity]] and high consumption of red meat. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Common risk factors in the development of rheumatoid arthritis are the family history of RA, cigarette smoking, race like more prevalent in Native Americans, strongly associated with Major histocompatibility complex (MHC) class II antigen HLA-DR4 and patient with silica and asbestos exposure. Less common risk factors are obesity and high consumption of red meat.
Risk Factors
Common Risk Factors
- Common risk factors in the development of rheumatoid arthritis include:
- Family history of rheumatoid arthritis.
- Cigarette smoking is a strong risk factor for developing RA. The duration of smoking co-related strongly with increased risk of RA.[1]
- Gender - Women is higher risk as compared to men.[2]
- Race:
- Native American groups have higher prevalence rates.
- African american and Caribbean region have lower prevalence rates.
- More common in monozygotic twins and diazygotic twins.[3]
- Genetic:
- It is strongly associated with the inherited tissue type Major histocompatibility complex (MHC) class II antigen HLA-DR4 (most specifically DR0401 and 0404), hence family history is an important risk factor.
- Occupational factors:
Less Common Risk Factors
- Less common risk factors in the development of rheumatoid arthritis include:
References
- ↑ Karlson EW, Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH (1999). <910::AID-ANR9>3.0.CO;2-D "A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals". Arthritis and Rheumatism. 42 (5): 910–7. doi:10.1002/1529-0131(199905)42:5<910::AID-ANR9>3.0.CO;2-D. PMID 10323446. Retrieved 2012-04-25. Unknown parameter
|month=ignored (help) - ↑ Crowson CS, Matteson EL, Myasoedova E; et al. (2011). "The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases". Arthritis and Rheumatism. 63 (3): 633–9. doi:10.1002/art.30155. PMC 3078757. PMID 21360492. Retrieved 2012-04-25. Unknown parameter
|month=ignored (help) - ↑ Aho K, Koskenvuo M, Tuominen J, Kaprio J (1986). "Occurrence of rheumatoid arthritis in a nationwide series of twins". The Journal of Rheumatology. 13 (5): 899–902. PMID 3820198. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Stolt P, Yahya A, Bengtsson C; et al. (2010). "Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis". Annals of the Rheumatic Diseases. 69 (6): 1072–6. doi:10.1136/ard.2009.114694. PMID 19966090. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help) - ↑ Stolt P, Källberg H, Lundberg I, Sjögren B, Klareskog L, Alfredsson L (2005). "Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study". Annals of the Rheumatic Diseases. 64 (4): 582–6. doi:10.1136/ard.2004.022053. PMC 1755463. PMID 15319232. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help) - ↑ Crowson CS, Matteson EL, Davis JM, Gabriel SE (2012). "Obesity fuels the upsurge in rheumatoid arthritis". Arthritis Care & Research. doi:10.1002/acr.21660. PMID 22514156. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help) - ↑ Liao KP, Alfredsson L, Karlson EW (2009). "Environmental influences on risk for rheumatoid arthritis". Current Opinion in Rheumatology. 21 (3): 279–83. doi:10.1097/BOR.0b013e32832a2e16. PMC 2898190. PMID 19318947. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help)