Churg-Strauss syndrome (patient information): Difference between revisions
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[[Symptom|Symptoms]] of [[eosinophilic granulomatosis with polyangiitis]] typically develops through three phases, include prodromal phase, eosinophilic phase, and vasculitis phase. Although these phases cannot be clinically distinguishable. | [[Symptom|Symptoms]] of [[eosinophilic granulomatosis with polyangiitis]] typically develops through three phases, include prodromal phase, eosinophilic phase, and vasculitis phase. Although these phases cannot be clinically distinguishable. | ||
* '''Prodromal phase:''' Most common manifestations | * '''Prodromal phase:''' Most common manifestations include | ||
* '''Eosinophilic phase:''' This phase is characterized by [[Eosinophilia|peripheral eosinophilia]] and | ** Runny nose | ||
* | ** Sneezing and itching | ||
* '''Vasculitic phase:''' Symptoms depending on organ system involvement. | ** Nasal polyps | ||
** [[Rhinitis|allergic rhinitis]] | |||
** [[asthma]]. | |||
* '''Eosinophilic phase:''' This phase is characterized by [[Eosinophilia|peripheral eosinophilia]] and accumulation of [[Eosinophil granulocyte|eosinophils]] in various organs. Most commonly involved organs are [[lung]] and [[Gastrointestinal tract|GI tract]]. | |||
** Asthma | |||
** Cough | |||
** Dyspnea | |||
** Abdominal pain | |||
** GI bleeding | |||
** Fatigue | |||
* '''Vasculitic phase:''' Symptoms depending on organ system involvement. Most commonly involved organs are lungs, kidneys, skin, heart, and peripheral nerves. | |||
** Weight loss | ** Weight loss | ||
** Generalized weakness | |||
** Fatique | ** Fatique | ||
** Skin rash and nodules | ** Skin rash and nodules | ||
Revision as of 18:42, 12 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Eosinophilic granulomatosis with polyangiitis previously called Churg-Strauss syndrome is a small and medium-sized necrotizing vasculitis, with extravascular granuloma formation. The etiology is not known. However, various environmental factors, allergens, genetics, and drugs may play a role in triggering disease process by activating eosinophils, B and T lymphocytes and macrophages. The disease is characterized by the presence of asthma, peripheral eosinophilia, rhinosinusitis, peripheral neuropathy and multiple organ involvements including skin, GI tract, and kidney.
What are the symptoms of Churg-Strauss syndrome
Symptoms of eosinophilic granulomatosis with polyangiitis typically develops through three phases, include prodromal phase, eosinophilic phase, and vasculitis phase. Although these phases cannot be clinically distinguishable.
- Prodromal phase: Most common manifestations include
- Runny nose
- Sneezing and itching
- Nasal polyps
- allergic rhinitis
- asthma.
- Eosinophilic phase: This phase is characterized by peripheral eosinophilia and accumulation of eosinophils in various organs. Most commonly involved organs are lung and GI tract.
- Asthma
- Cough
- Dyspnea
- Abdominal pain
- GI bleeding
- Fatigue
- Vasculitic phase: Symptoms depending on organ system involvement. Most commonly involved organs are lungs, kidneys, skin, heart, and peripheral nerves.
- Weight loss
- Generalized weakness
- Fatique
- Skin rash and nodules
- Numbness and tingling sensation of hands and feet
- Abdominal pain
- Diarrhea
- Nausea and vomiting
- Shortness of breath (dyspnea) from asthma or congestive heart failure
- Cough
- Chest pain
- Blood in your urine (hematuria)
What causes Churg-Strauss syndrome?
There are no established causes for eosinophilic granulomatosis with polyangiitis. However, various allergens, infections, vaccinations and drugs may act as a triggering agents, and are responsible for developing disease. Genetics may also play a role.