Glomerulonephritis differential diagnosis: Difference between revisions
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* Hodgkin lymphoma | * Hodgkin lymphoma | ||
* Thrombosis (due to urinary loss of antithrombin-III) | * Thrombosis (due to urinary loss of antithrombin-III) | ||
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* Normal | * Normal | ||
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* Fusion of podocytes | * Fusion of podocytes | ||
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!Focal segmental glomerulosclerosis | !Focal segmental glomerulosclerosis |
Revision as of 15:16, 16 April 2018
Glomerulonephritis Main page |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Glomerulonephritis may be proliferative or non-proliferative and may be associated with nephrotic or nephritic features. The various types of glomerulonephritides should be differentiated from each other based on associations, presence of pitting edema, hemeturia, hypertension, hemoptysis, oliguria, peri-orbital edema, hyperlipidemia, type of antibodies, light and electron microscopic features.
Differential Diagnosis
The following table differentiates between various types of glomerulonephritides:
Glomerulonephritis | Sub-entity | Causes and associations | History and Symtoms | Laboratory Findings | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hyperlipidemia and hypercholesterolemia | Nephrotic features | Nephritic features | ANCA | Anti-glomerular basement membrane antibody (Anti-GBM antibody) | Immune complex formation | Light microscope | Electron microscope | Immunoflourescence pattern | ||||||||||
History | Pitting edema | Hemeturia (pre-dominantly microscopic) | Hypertension | Hemoptysis | Oliguria | Peri-orbital edema | ||||||||||||
Non-proliferative | Minimal change disease |
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+ |
- |
- |
- |
+/- |
- |
+ |
+ |
- |
- |
- |
- |
|
|
- |
Focal segmental glomerulosclerosis |
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|
+ | - | - | - | +/- | - | + | + | - | - | - | - |
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|
- | |
Membranous glomerulonephritis |
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+ | - | - | - | +/- | - | + | + | - | - | - | + |
|
|
- | ||
Proliferative | IgA nephropathy |
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|
+/- | + | + | - | + | +/- | - | - | + | - | - | + |
|
|
- |
Rapidly progressive glomerulonephritis |
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|
+/- | + | + | + | + | + | - | - | + | - | + | + |
|
|
+ (Linear) | |
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+/- | + | + | + | + | + | - | - | + | - | - | + |
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+ (Granular) | ||
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+/- | + | + | + | + | + | - | - | + | + (C-ANCA) | - | - |
|
- (pauci-immune) | +/- | ||
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|
+/- | + | + | + | + | + | - | - | + |
+ (C-ANCA) |
- | - |
|
- (pauci-immune) | - | ||
|
|
+/- | + | + | + | + | + | - | - | + |
+ (P-ANCA) |
- | - |
|
- (pauci-immune) | - | ||
Membranoproliferative glomerulonephritis |
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+/- | + | + | + | + | + | - | + | - | - | - | + |
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|
+ (Granular) |