Scleroderma causes

Scleroderma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]

Overview

The cause of scleroderma has not been identified. There is a possibility of an underlying immunologic abnormality. To review risk factors for the development of scleroderma click here.

Causes

The cause of scleroderma remains unknown. Although there is thought to be an underlying immunologic abnormality since there are certain characteristic autoantibodies present:

• Antinuclear antibody (ANA)
• Anti-centromere antibody
• Anti-scl-70 antibody