Chronic myelogenous leukemia laboratory tests: Difference between revisions

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==Laboratory Findings==
==Laboratory Findings==
Laboratory findings associated with chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref>
Laboratory findings associated with chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref>
*[[Complete blood count]]
:*Increased [[granulocyte]]s of all types, especially [[basophil]]s and [[eosinophil]]s
:*[[Thrombocytopenia]]
:*[[Anemia]]
*Blood chemistry
:* The following may be elevated:
::*Blood urea nitrogen ([[BUN]])
::*[[Creatinine]]
::*[[Phosphate]]
::*[[Lactate dehydrogenase]] (LDH)
::*[[Alanine aminotransferase]] (ALT)
::*[[Aspartate transaminase]] (AST)
::*[[Uric acid]]
*Bleeding and clotting factor
:*The following blood levels may be elevated:
::*[[Prothrombin time]] (PT) or [[international normalized ratio]] (INR)
::*[[Partial thromboplastin time]] (PTT)
*[[Cytochemistry]]
:*Cytochemistry helps determine the type of cells that are present
*[[Flow cytometry]]
:* Flow cytometry helps determine the type of cells that are present
*[[Cytogenetics]]
:*Chromosome changes that may occur in some people with leukemia include:
::*[[Translocations]]
::*Inversions
::*Loss or gain of a chromosome number
*[[Fluorescent in situ hybridization]] (FISH)
:*Similar to cytogenetics, but more specific
*Polymerase chain reaction
:*Helpful to detect specific abnormalities in blood or bone marrow cells. Abnormalities can be found even if very few leukemia cells are present in a tissue sample.
==Gallery==
==Gallery==
<gallery widths=200px class="center">
<gallery widths="200px" class="center">
CML.jpg| Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.<ref name="cdc">Center for Disease Control and Prevention. Public Health Image Library 2015.http://phil.cdc.gov/phil/details_linked.asp?pid=6</ref>
CML.jpg| Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.<ref name="cdc">Center for Disease Control and Prevention. Public Health Image Library 2015.http://phil.cdc.gov/phil/details_linked.asp?pid=6</ref>
Leukemia-flurescent.jpg| A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).<ref name="cdc">Center for Disease Control and Prevention. Public Health Image Library 2015.http://phil.cdc.gov/phil/details.asp</ref>
Leukemia-flurescent.jpg| A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).<ref name="cdc">Center for Disease Control and Prevention. Public Health Image Library 2015.http://phil.cdc.gov/phil/details.asp</ref>

Revision as of 19:29, 19 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Laboratory findings consistent with the diagnosis of chronic myelogenous leukemia include leukocytosis, thrombocytopenia, and anemia.

Laboratory Findings

Laboratory findings associated with chronic myelogenous leukemia include:[1]

Gallery

  • Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]
    Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]
  • A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]
    A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]

References

  1. ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
  2. ↑ 2.0 2.1 Center for Disease Control and Prevention. Public Health Image Library 2015.http://phil.cdc.gov/phil/details_linked.asp?pid=6


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