Adult-onset Still's disease laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, inflammatory marker such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) may be elevated. Complete blood count may show leukocytosis with a left shift (increased neutrophils), anemia thrombocytosis or pancytopenia (in cases of hemophagocytic syndrome). | Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying [[inflammatory]] process, [[inflammatory]] marker such as [[erythrocyte sedimentation rate]] ([[ESR]]) and [[C-reactive protein]] ([[CRP]]) may be elevated. [[Complete blood count]] may show [[leukocytosis]] with a left shift (increased [[neutrophils]]), [[anemia]], [[thrombocytosis]] or [[pancytopenia]] (in cases of [[hemophagocytic syndrome]]). | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
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=== Inflammatory markers === | === Inflammatory markers === | ||
* Increased ferritin (greater than 5 times of upper limit of normal may aid in diagnosis- > 1000 ng/ml) | * Increased [[ferritin]] (greater than 5 times of upper limit of normal may aid in diagnosis- > 1000 ng/ml) | ||
* Elevated ESR | * Elevated [[Erythrocyte sedimentation rate|ESR]] | ||
* Elevated CRP | * Elevated [[CRP]] | ||
=== Complete blood count === | === Complete blood count === | ||
* Leukocytosis with pre-dominant neutrophils (left shift) | * [[Leukocytosis]] with pre-dominant [[neutrophils]] (left shift) | ||
* Anemia | * [[Anemia]] | ||
* Thrombocytosis | * [[Thrombocytosis]] | ||
* Pancytopenia (in case of hemophagocytic syndrome) | * [[Pancytopenia]] (in case of [[hemophagocytic syndrome]]) | ||
=== Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT) === | === Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT) === | ||
* Increased in case of disseminated intravascular coagulation (DIC) | * Increased in case of [[disseminated intravascular coagulation]] ([[Disseminated intravascular coagulation|DIC]]) | ||
=== Liver function tests (LFTs) === | === Liver function tests (LFTs) === | ||
* Increased lactic dehydrogenase | * Increased [[lactic dehydrogenase]] | ||
* Increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) | * Increased [[aspartate aminotransferase]] ([[Aspartate transaminase|AST]]) and [[alanine aminotransferase]] ([[ALT]]) | ||
* Increased γ‐glutamyltransferase | * Increased γ‐glutamyltransferase | ||
* Increased bilirubin | * Increased [[bilirubin]] | ||
==References== | ==References== | ||
Revision as of 14:19, 23 April 2018
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Adult-onset Still's disease |
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Differentiating Adult-onset Still’s Disease from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Template:Adult-onset Still's disease On the Web |
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American Roentgen Ray Society Images of Template:Adult-onset Still's disease |
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Template:Adult-onset Still's disease in the news |
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Risk calculators and risk factors for Template:Adult-onset Still's disease |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, inflammatory marker such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) may be elevated. Complete blood count may show leukocytosis with a left shift (increased neutrophils), anemia, thrombocytosis or pancytopenia (in cases of hemophagocytic syndrome).
Laboratory Findings
Adult-onset Still's disease (AOSD) is diagnosed based on clinical presentation and history findings. However, due to underlying inflammatory process, the following laboratory abnormalities may be observed:
Inflammatory markers
- Increased ferritin (greater than 5 times of upper limit of normal may aid in diagnosis- > 1000 ng/ml)
- Elevated ESR
- Elevated CRP
Complete blood count
- Leukocytosis with pre-dominant neutrophils (left shift)
- Anemia
- Thrombocytosis
- Pancytopenia (in case of hemophagocytic syndrome)
Partial thromboplastin time (PTT) and activated partial thromboplastin time (aPTT)
- Increased in case of disseminated intravascular coagulation (DIC)
Liver function tests (LFTs)
- Increased lactic dehydrogenase
- Increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT)
- Increased γ‐glutamyltransferase
- Increased bilirubin