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{{Rheumatoid arthritis}}
{{Rheumatoid arthritis}}
{{CMG}}; {{AE}} {{AN}}
{{CMG}}; {{AE}} {{MKK}}


==Future or Investigational Therapies==
==Future or Investigational Therapies==
===Pain relief===
===Pain relief===
Recent research indicates that [[cytokines]], a group of chemicals that are produced by various cells in the body, may be responsible for generating the response of chronic [[Pain and nociception|pain]] associated with Rheumatoid Arthritis. Medications that affect the release of cytokines or block the action of cytokines may reduce the response of chronic pain. Various anti-cytokine medications are now being used to treat painful disease states such as Rheumatoid Arthritis, and [[Crohn's Disease]]. In addition, research using the anti-cytokine medication, [[Thalidomide]], is being evaluated for its effect in treating chronic pain associated with [[Arachnoiditis]]. Food (vegetables) with higher water content should be avoided.
Various anti-cytokine medications are now being used to treat painful disease states such as Rheumatoid Arthritis, and [[Crohn's Disease]]. In addition, research using the anti-cytokine medication, [[Thalidomide]], is being evaluated for its effectiveness in treating chronic pain associated with [[Arachnoiditis]]. Food (vegetables) with higher water content should be avoided.


===Specific desensitization===
===Specific desensitization===
An experimental treatment known as [[enzyme potentiated desensitization]] (EPD) is now under development for the treatment of rheumatoid arthritis and other [[autoimmune diseases]].  EPD uses dilutions of allergen (in this case type 2 [[collagen]]) and an enzyme, β-glucuronidase, to which T-regulatory lymphocytes respond by favouring desensitization, rather than sensitization.  Initial results are encouraging <ref>[http://www.epidyme.com/ra.html EPD treatment of rheumatoid arthritis proof of concept results on Epidyme website] use of EPD to treat autoimmune diseases.</ref> but the treatment is still at an early stage of development.
An experimental treatment known as [[enzyme potentiated desensitization]] (EPD) is now under development for the treatment of rheumatoid arthritis.


===Other therapies===
===Other therapies===

Latest revision as of 17:43, 25 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Future or Investigational Therapies

Pain relief

Various anti-cytokine medications are now being used to treat painful disease states such as Rheumatoid Arthritis, and Crohn's Disease. In addition, research using the anti-cytokine medication, Thalidomide, is being evaluated for its effectiveness in treating chronic pain associated with Arachnoiditis. Food (vegetables) with higher water content should be avoided.

Specific desensitization

An experimental treatment known as enzyme potentiated desensitization (EPD) is now under development for the treatment of rheumatoid arthritis.

Other therapies

Other therapies are weight loss, occupational therapy, podiatry, physiotherapy, joint injections, and special tools to improve hard movements (e.g. special tin-openers).

Severely affected joints may require joint replacement surgery, such as knee replacement.

References

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