* The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
* The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
* Synovial fluid is aspirated off the inflamed joint by careful arthrocentesis.
*[[File:MSUcrystals.jpg|thumb|Monosodium urate crystals showing negative birefringence<ref name="url00214108 | PEIR Digital Library">{{cite web |url=http://peir.path.uab.edu/library/picture.php?/22177/search/7357 |title=00214108 | PEIR Digital Library |format= |work= |accessdate=}}</ref>]]Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis.
* The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687
* The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687
* It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533
The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
Monosodium urate crystals showing negative birefringence[1]Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis.
The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687
It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533
