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[[File:MSUcrystals.jpg|thumb|Monosodium urate crystals showing negative birefringence<ref name="url00214108 | PEIR Digital Library">{{cite web |url=http://peir.path.uab.edu/library/picture.php?/22177/search/7357 |title=00214108 | PEIR Digital Library |format= |work= |accessdate=}}</ref>]] | |||
__NOTOC__ | __NOTOC__ | ||
{{Gout}} | {{Gout}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} | ||
== Overview == | == Overview == | ||
== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
* The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals. | * The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals. | ||
* | * Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis. | ||
* The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687 | * The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687 | ||
* It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533 | * It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533 | ||
Revision as of 12:05, 27 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Study of Choice
- The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
- Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis.
- The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687
- It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533