Takayasu's arteritis causes: Difference between revisions
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==Overview== | ==Overview== | ||
The cause of Takayasu's arteritis is idiopathic but genetic, immunologic and infectious factors play important role in the development of Takayasu's arteritis. | The cause of Takayasu's arteritis is [[idiopathic]] but [[Genetics|genetic]], [[Immunology|immunologic]] and [[Infection|infectious]] factors play important role in the development of Takayasu's arteritis. | ||
==Causes== | ==Causes== | ||
The cause of Takayasu's arteritis is idiopathic but genetic, immunologic and infectious factors play important role in the development of Takayasu's arteritis.<ref name="pmid10980348">{{cite journal |vauthors=Salazar M, Varela A, Ramirez LA, Uribe O, Vasquez G, Egea E, Yunis EJ, Iglesias-Gamarra A |title=Association of HLA-DRB1*1602 and DRB1*1001 with Takayasu arteritis in Colombian mestizos as markers of Amerindian ancestry |journal=Int. J. Cardiol. |volume=75 Suppl 1 |issue= |pages=S113–6 |date=August 2000 |pmid=10980348 |doi= |url=}}</ref><ref name="pmid12655">{{cite journal |vauthors=Lupi-Herrera E, Sánchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE |title=Takayasu's arteritis. Clinical study of 107 cases |journal=Am. Heart J. |volume=93 |issue=1 |pages=94–103 |date=January 1977 |pmid=12655 |doi= |url=}}</ref> | The cause of Takayasu's arteritis is [[idiopathic]] but [[Genetics|genetic]], [[Immunology|immunologic]] and [[Infection|infectious]] factors play important role in the development of Takayasu's arteritis.<ref name="pmid10980348">{{cite journal |vauthors=Salazar M, Varela A, Ramirez LA, Uribe O, Vasquez G, Egea E, Yunis EJ, Iglesias-Gamarra A |title=Association of HLA-DRB1*1602 and DRB1*1001 with Takayasu arteritis in Colombian mestizos as markers of Amerindian ancestry |journal=Int. J. Cardiol. |volume=75 Suppl 1 |issue= |pages=S113–6 |date=August 2000 |pmid=10980348 |doi= |url=}}</ref><ref name="pmid12655">{{cite journal |vauthors=Lupi-Herrera E, Sánchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE |title=Takayasu's arteritis. Clinical study of 107 cases |journal=Am. Heart J. |volume=93 |issue=1 |pages=94–103 |date=January 1977 |pmid=12655 |doi= |url=}}</ref> | ||
* Genetic factors''':''' | * [[Genetics|Genetic]] factors''':''' | ||
** Takayasu arteritis has been associated with different [[Human leukocyte antigen|human leucocyte antigen]] ([[Human leukocyte antigen|HLA]]) alleles in different populations. | ** Takayasu arteritis has been associated with different [[Human leukocyte antigen|human leucocyte antigen]] ([[Human leukocyte antigen|HLA]]) [[Allele|alleles]] in different populations. | ||
** In Japan and Korea there is a clear association with the extended [[haplotype]]: HLA B*52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02-DPB1*0901. | ** In Japan and Korea there is a clear association with the extended [[haplotype]]: HLA B*52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02-DPB1*0901. | ||
* Immunologic: | * [[Immunology|Immunologic]]: | ||
** Immunohistopathologic examination has shown that the infiltrating cells in aortic tissue mainly consist of killer cells, especially gamma delta [[T lymphocytes]]. | ** Immunohistopathologic examination has shown that the infiltrating cells in [[Aorta|aortic]] tissue mainly consist of [[Natural killer cell|killer cells]], especially gamma delta [[T lymphocytes]]. | ||
* Infectious agents: | * [[Infection|Infectious]] agents: | ||
** [[Spirochetes]] | ** [[Spirochetes]] | ||
** ''[[Mycobacterium tuberculosis]]'' | ** ''[[Mycobacterium tuberculosis]]'' | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farnaz Khalighinejad, MD [2]
Overview
The cause of Takayasu's arteritis is idiopathic but genetic, immunologic and infectious factors play important role in the development of Takayasu's arteritis.
Causes
The cause of Takayasu's arteritis is idiopathic but genetic, immunologic and infectious factors play important role in the development of Takayasu's arteritis.[1][2]
- Genetic factors:
- Takayasu arteritis has been associated with different human leucocyte antigen (HLA) alleles in different populations.
- In Japan and Korea there is a clear association with the extended haplotype: HLA B*52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02-DPB1*0901.
- Immunologic:
- Immunohistopathologic examination has shown that the infiltrating cells in aortic tissue mainly consist of killer cells, especially gamma delta T lymphocytes.
- Infectious agents:
References
- ↑ Salazar M, Varela A, Ramirez LA, Uribe O, Vasquez G, Egea E, Yunis EJ, Iglesias-Gamarra A (August 2000). "Association of HLA-DRB1*1602 and DRB1*1001 with Takayasu arteritis in Colombian mestizos as markers of Amerindian ancestry". Int. J. Cardiol. 75 Suppl 1: S113–6. PMID 10980348.
- ↑ Lupi-Herrera E, Sánchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE (January 1977). "Takayasu's arteritis. Clinical study of 107 cases". Am. Heart J. 93 (1): 94–103. PMID 12655.