Chronic myelogenous leukemia historical perspective: Difference between revisions
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{{CMG}} {{AE}} {{MJK}} | {{CMG}} {{AE}} {{MJK}} | ||
==Overview== | ==Overview== | ||
In the 1840s, the first cases of chronic myelogenous leukemia ([[splenomegaly]] with high [[leukocyte]] count) was reported in France, Germany, and Scotland. In 1960, the association of [[Philadelphia chromosome]] with the pathogenesis of chronic myelogenous leukemia was first discovered. In 1973, (9;22) translocation was first discovered. Definition of the breakpoint cluster region on chromosome 22 was first reported in 1984 and the demonstration of the BCR-ABL transcript in CML was first discovered in 1985. From 1980 onwards allogeneic stem cell transplantation (SCT) became the treatment of choice for eligible patients. In 1998, the era of tyrosine kinase inhibitors (TKI) began. | In the 1840s, the first cases of chronic myelogenous leukemia ([[splenomegaly]] with high [[leukocyte]] count) was reported in France, Germany, and Scotland. In 1960, the association of [[Philadelphia chromosome]] with the pathogenesis of chronic myelogenous leukemia was first discovered. In 1973, (9;22) translocation was first discovered. Definition of the breakpoint cluster region on chromosome 22 was first reported in 1984 and the demonstration of the BCR-ABL transcript in CML was first discovered in 1985. From 1980 onwards allogeneic stem cell transplantation (SCT) became the treatment of choice for eligible patients. In 1998, the era of tyrosine kinase inhibitors (TKI) began. | ||
==Historical Perspective== | ==Historical Perspective== | ||
Important dates in chronic myelogenous leukemia: | Important dates in chronic myelogenous leukemia: | ||
* In the 1840s, the first cases of chronic myelogenous leukemia was first reported. | * In the 1840s, the first cases of chronic myelogenous leukemia was first reported. | ||
* In 1960, [[Philadelphia chromosome]] was first discovered by Peter Nowell and David Hungerford. | * In 1960, [[Philadelphia chromosome]] was first discovered by Peter Nowell and David Hungerford. | ||
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==References== | ==References== | ||
{{Reflist | {{Reflist}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Revision as of 12:07, 30 April 2018
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Chronic myelogenous leukemia Microchapters |
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Differentiating Chronic myelogenous leukemia from other Diseases |
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Chronic myelogenous leukemia historical perspective On the Web |
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Directions to Hospitals Treating Chronic myelogenous leukemia |
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Risk calculators and risk factors for Chronic myelogenous leukemia historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
In the 1840s, the first cases of chronic myelogenous leukemia (splenomegaly with high leukocyte count) was reported in France, Germany, and Scotland. In 1960, the association of Philadelphia chromosome with the pathogenesis of chronic myelogenous leukemia was first discovered. In 1973, (9;22) translocation was first discovered. Definition of the breakpoint cluster region on chromosome 22 was first reported in 1984 and the demonstration of the BCR-ABL transcript in CML was first discovered in 1985. From 1980 onwards allogeneic stem cell transplantation (SCT) became the treatment of choice for eligible patients. In 1998, the era of tyrosine kinase inhibitors (TKI) began.
Historical Perspective
Important dates in chronic myelogenous leukemia:
- In the 1840s, the first cases of chronic myelogenous leukemia was first reported.
- In 1960, Philadelphia chromosome was first discovered by Peter Nowell and David Hungerford.
- In 1973, (9;22) translocation was first discovered.
- From 1980, allogeneic stem cell transplantation (SCT) became the treatment of choice for eligible patients.
- In 1984, definition of the breakpoint cluster region on chromosome 22 was first reported.
- In 1985, the BCR-ABL transcript was first discovered.
- In 1998, the era of tyrosine kinase inhibitors (TKI) began.