Undifferentiated connective tissue disease medical therapy: Difference between revisions

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Revision as of 15:42, 30 April 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

The pharmacologic medical therapy is recommended based on the rheumatic disease pattern manifested by the patient such as methotrexate in those exhibiting arthritis and dermatitis.

Medical Therapy

Pharmacologic medical therapy is recommended based on the rheumatic disease pattern manifested by the patient:

Arthritis and dermatitis

Oral regimen
- Preferred regimen (1): Methotrexate 7.5 mg PO q24h for 6 months (not used for CNS symptoms or serositis)^[1]
  - Dose is gradually increased to 13.6 mg after 6 months

- - - - Alternative regimen (3):drug name 500 mg PO q6h for 14–21 days
  - 2.1.2 Pediatric
    - Parenteral regimen
      - Preferred regimen (1): drug name 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
      - Alternative regimen (1): drug name 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)

PO q12h for 14 (14–21) days (maximum, 500 mg per dose)

- - - - Alternative regimen (1): drug name 10 mg/kg PO q6h 7–10 days (maximum, 500 mg per day)
      - Alternative regimen (2): drug name 7.5 mg/kg PO q12h for 14–21 days (maximum, 500 mg per dose)
      - Alternative regimen (3): drug name 12.5 mg/kg PO q6h for 14–21 days (maximum,500 mg per dose)

References

↑ Wise CM, Vuyyuru S, Roberts WN (June 1996). "Methotrexate in nonrenal lupus and undifferentiated connective tissue disease--a review of 36 patients". J. Rheumatol. 23 (6): 1005–10. PMID 8782131.

Template:WH Template:WS

[pmid8782131-1] Wise CM, Vuyyuru S, Roberts WN (June 1996). "Methotrexate in nonrenal lupus and undifferentiated connective tissue disease--a review of 36 patients". J. Rheumatol. 23 (6): 1005–10. PMID 8782131.

[1]

@@ Line 9: / Line 9: @@
 *Pharmacologic medical therapy is recommended based on the rheumatic disease pattern manifested by the patient:
 === Arthritis and dermatitis ===
-* Oral regimen
+*Oral regimen
+**Preferred regimen (1): [[Methotrexate]] 7.5 mg PO q24h for 6 months '''(not used for CNS symptoms or serositis)'''<ref name="pmid8782131">{{cite journal |vauthors=Wise CM, Vuyyuru S, Roberts WN |title=Methotrexate in nonrenal lupus and undifferentiated connective tissue disease--a review of 36 patients |journal=J. Rheumatol. |volume=23 |issue=6 |pages=1005–10 |date=June 1996 |pmid=8782131 |doi= |url=}}</ref>
-** Preferred regimen (1): [[Methotrexate]] 7.5 mg PO q24h for 6 months '''(not used for CNS symptoms or serositis)'''<ref name="pmid8782131">{{cite journal |vauthors=Wise CM, Vuyyuru S, Roberts WN |title=Methotrexate in nonrenal lupus and undifferentiated connective tissue disease--a review of 36 patients |journal=J. Rheumatol. |volume=23 |issue=6 |pages=1005–10 |date=June 1996 |pmid=8782131 |doi= |url=}}</ref>
 *** Dose is gradually increased to 13.6 mg after 6 months
-***
-**** Parenteral regimen
-***** Preferred regimen (1): [[drug name]] 2 g IV q24h for 14 (14–21) days
-***** Alternative regimen (1): [[drug name]] 2 g IV q8h for 14 (14–21) days
-***** Alternative regimen (2): [[drug name]] 18–24 MU/day IV q4h for 14 (14–21) days
-***** Preferred regimen (1): [[drug name]] 500 mg PO q8h for 14 (14–21) days
-***** Preferred regimen (2): [[drug name]] 100 mg PO q12h for 14 (14–21) days
-***** Preferred regimen (3): [[drug name]] 500 mg PO q12h for 14 (14–21) days
-***** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days
-***** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
 ***** Alternative regimen (3):[[drug name]] 500 mg PO q6h for 14–21 days
 *** 2.1.2 '''Pediatric'''
@@ Line 29: / Line 18: @@
 ***** Preferred regimen (1): [[drug name]] 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
 ***** Alternative regimen (1): [[drug name]] 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
-***** Alternative regimen (2):  [[drug name]] 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day) '<nowiki/>'''''(Contraindications/specific instructions)''''''
+PO q12h for 14 (14–21) days  (maximum, 500 mg per dose)
-**** Oral regimen
-***** Preferred regimen (1):  [[drug name]] 50 mg/kg/day PO q8h for 14 (14–21) days  (maximum, 500 mg per dose)
-***** Preferred regimen (2): [[drug name]] '''(for children aged ≥ 8 years)''' 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
-***** Preferred regimen (3): [[drug name]] 30 mg/kg/day PO q12h for 14 (14–21) days  (maximum, 500 mg per dose)
 ***** Alternative regimen (1):  [[drug name]] 10 mg/kg PO q6h 7–10 days  (maximum, 500 mg per day)
 ***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h for 14–21 days  (maximum, 500 mg per dose)