Microscopic polyangiitis pathophysiology: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Microscopic polyangiitis}}
{{Microscopic polyangiitis}}
{{CMG}}{{APM}}{{AE}}{{KW}}{{VKG}}
{{CMG}} ; {{AE}}{{KW}}{{VKG}}


==Overview==
==Overview==

Revision as of 19:33, 30 April 2018

Microscopic polyangiitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Microscopic polyangiitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Radiation therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Microscopic polyangiitis pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Microscopic polyangiitis pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Microscopic polyangiitis pathophysiology

CDC on Microscopic polyangiitis pathophysiology

Microscopic polyangiitis pathophysiology in the news

Blogs on Microscopic polyangiitis pathophysiology

Directions to Hospitals Treating Type chapter name here

Risk calculators and risk factors for Microscopic polyangiitis pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [2]Vamsikrishna Gunnam M.B.B.S [3]

Overview

The pathogenesis of Microscopic polyangiitis is currently not fully understood. However, certain hypothesizes have been made to determine possible factors that may trigger the disease such as environmental factors and anti-neutrophil cytoplasmic antibodies. Capillaries and venules are involved in the pathogenesis of microscopic polyangiitis.The paucity of immunoglobulin deposition is shown in Immunohistochemical staining.

Pathogenesis

Pathogenesis

Environmental triggers
  • Environmental triggers such as exposure to silica have been found to influence the progression of the disease.But, its role in disease progression is not fully understood.[1]

Anti-neutrophil cytoplasmic antibodies (ANCA)[2][3][4][5]

Genetics

Gross Pathology

Microscopic Pathology

Genetics

Gross Pathology

Microscopic Pathology

References

  1. de Lind van Wijngaarden RA, van Rijn L, Hagen EC, Watts RA, Gregorini G, Tervaert JW; et al. (2008). "Hypotheses on the etiology of antineutrophil cytoplasmic autoantibody associated vasculitis: the cause is hidden, but the result is known". Clin J Am Soc Nephrol. 3 (1): 237–52. doi:10.2215/CJN.03550807. PMID 18077783.
  2. Eisenberger U, Fakhouri F, Vanhille P, Beaufils H, Mahr A, Guillevin L, Lesavre P, Noël LH (July 2005). "ANCA-negative pauci-immune renal vasculitis: histology and outcome". Nephrol. Dial. Transplant. 20 (7): 1392–9. doi:10.1093/ndt/gfh830. PMID 15855209.
  3. Falk RJ, Nachman PH, Hogan SL, Jennette JC (May 2000). "ANCA glomerulonephritis and vasculitis: a Chapel Hill perspective". Semin. Nephrol. 20 (3): 233–43. PMID 10855933.
  4. Vizjak A, Rott T, Koselj-Kajtna M, Rozman B, Kaplan-Pavlovcic S, Ferluga D (March 2003). "Histologic and immunohistologic study and clinical presentation of ANCA-associated glomerulonephritis with correlation to ANCA antigen specificity". Am. J. Kidney Dis. 41 (3): 539–49. doi:10.1053/ajkd.2003.50142. PMID 12612976.
  5. Neumann I, Regele H, Kain R, Birck R, Meisl FT (March 2003). "Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis". Nephrol. Dial. Transplant. 18 (3): 524–31. PMID 12584274.
  6. Kallenberg CG, Heeringa P, Stegeman CA (2006). "Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides". Nat Clin Pract Rheumatol. 2 (12): 661–70. doi:10.1038/ncprheum0355. PMID 17133251.
  7. Tsuchiya N (2012). "Genetics of microscopic polyangiitis in the Japanese population". Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
  8. Gómez-Puerta JA, Espinosa G, Morlà R, Cid MC, Cervera R (2009). "Interstitial lung disease as a presenting manifestation of microscopic polyangiitis successfully treated with mycophenolate mofetil". Clin Exp Rheumatol. 27 (1): 166–7. PMID 19327249.
  9. Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.
  10. Savage CO, Winearls CG, Evans DJ, Rees AJ, Lockwood CM (1985). "Microscopic polyarteritis: presentation, pathology and prognosis". Q J Med. 56 (220): 467–83. PMID 4048389.
  11. Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.
  12. Kallenberg CG, Heeringa P, Stegeman CA (2006). "Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides". Nat Clin Pract Rheumatol. 2 (12): 661–70. doi:10.1038/ncprheum0355. PMID 17133251.
  13. Tsuchiya N (2012). "Genetics of microscopic polyangiitis in the Japanese population". Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
  14. Gómez-Puerta JA, Espinosa G, Morlà R, Cid MC, Cervera R (2009). "Interstitial lung disease as a presenting manifestation of microscopic polyangiitis successfully treated with mycophenolate mofetil". Clin Exp Rheumatol. 27 (1): 166–7. PMID 19327249.
  15. Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.
  16. Savage CO, Winearls CG, Evans DJ, Rees AJ, Lockwood CM (1985). "Microscopic polyarteritis: presentation, pathology and prognosis". Q J Med. 56 (220): 467–83. PMID 4048389.
  17. Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.

Template:WH Template:WS