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| ==Overview== | | ==Overview== |
| The cause of Takayasu's arteritis is [[idiopathic]] but [[Genetics|genetic]], [[Immunology|immunologic]] and [[Infection|infectious]] factors play important role in the development of Takayasu's arteritis. | | The cause of Takayasu's arteritis has not been identified. To review risk factors for the development of Takayasu's arteritis, click here. |
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| ==Causes== | | ==Causes== |
| The cause of Takayasu's arteritis is [[idiopathic]] but [[Genetics|genetic]], [[Immunology|immunologic]] and [[Infection|infectious]] factors play important role in the development of Takayasu's arteritis.<ref name="pmid10980348">{{cite journal |vauthors=Salazar M, Varela A, Ramirez LA, Uribe O, Vasquez G, Egea E, Yunis EJ, Iglesias-Gamarra A |title=Association of HLA-DRB1*1602 and DRB1*1001 with Takayasu arteritis in Colombian mestizos as markers of Amerindian ancestry |journal=Int. J. Cardiol. |volume=75 Suppl 1 |issue= |pages=S113–6 |date=August 2000 |pmid=10980348 |doi= |url=}}</ref><ref name="pmid12655">{{cite journal |vauthors=Lupi-Herrera E, Sánchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE |title=Takayasu's arteritis. Clinical study of 107 cases |journal=Am. Heart J. |volume=93 |issue=1 |pages=94–103 |date=January 1977 |pmid=12655 |doi= |url=}}</ref> | | The cause of Takayasu's arteritis has not been identified. To review risk factors for the development of Takayasu's arteritis, click here. |
| * [[Genetics|Genetic]] factors''':'''
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| ** Takayasu arteritis has been associated with different [[Human leukocyte antigen|human leucocyte antigen]] ([[Human leukocyte antigen|HLA]]) [[Allele|alleles]] in different populations.
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| ** In Japan and Korea there is a clear association with the extended [[haplotype]]: HLA B*52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02-DPB1*0901.
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| * [[Immunology|Immunologic]]:
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| ** Immunohistopathologic examination has shown that the infiltrating cells in [[Aorta|aortic]] tissue mainly consist of [[Natural killer cell|killer cells]], especially gamma delta [[T lymphocytes]].
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| * [[Infection|Infectious]] agents:
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| ** [[Spirochetes]]
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| ** ''[[Mycobacterium tuberculosis]]''
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| ** [[Streptococcal]] organisms
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| ==References== | | ==References== |
| {{reflist|2}} | | {{reflist|2}} |
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| [[Category:Medicine]]
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| [[Category:Rheumatology]]
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| [[Category:Up-To-Date]]
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farnaz Khalighinejad, MD [2]
Overview
The cause of Takayasu's arteritis has not been identified. To review risk factors for the development of Takayasu's arteritis, click here.
Causes
The cause of Takayasu's arteritis has not been identified. To review risk factors for the development of Takayasu's arteritis, click here.
References