Acute tubular necrosis causes: Difference between revisions
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===Common Causes=== | ===Common Causes=== | ||
[Disease name] may be caused by: | [Disease name] may be caused by: | ||
* '''Toxic [[acute tubular necrosis]]:''' | * '''Ischemic [[acute tubular necrosis]]:''' | ||
** Volume loss:<ref name="pmid23798302">{{cite journal |vauthors=Basile DP, Anderson MD, Sutton TA |title=Pathophysiology of acute kidney injury |journal=Compr Physiol |volume=2 |issue=2 |pages=1303–53 |date=April 2012 |pmid=23798302 |pmc=3919808 |doi=10.1002/cphy.c110041 |url=}}</ref> | |||
*** Hemorrhage | |||
*** Severe vomitings and diarrhea | |||
*** Burns<ref name="pmid23966894">{{cite journal |vauthors=Ibrahim AE, Sarhane KA, Fagan SP, Goverman J |title=Renal dysfunction in burns: a review |journal=Ann Burns Fire Disasters |volume=26 |issue=1 |pages=16–25 |date=March 2013 |pmid=23966894 |pmc=3741002 |doi= |url=}}</ref> | |||
*** Third space fluid sequestration | |||
*** Extensive use of diuretics and osmotic diuresis | |||
** Profound hypotension<ref name="pmid25150229">{{cite journal |vauthors=Ramoutar V, Landa C, James LR |title=Acute tubular necrosis (ATN) presenting with an unusually prolonged period of marked polyuria heralded by an abrupt oliguric phase |journal=BMJ Case Rep |volume=2014 |issue= |pages= |date=August 2014 |pmid=25150229 |pmc=4154042 |doi=10.1136/bcr-2013-201030 |url=}}</ref><ref name="pmid3784280">{{cite journal |vauthors=Ratcliffe PJ, Moonen CT, Holloway PA, Ledingham JG, Radda GK |title=Acute renal failure in hemorrhagic hypotension: cellular energetics and renal function |journal=Kidney Int. |volume=30 |issue=3 |pages=355–60 |date=September 1986 |pmid=3784280 |doi= |url=}}</ref> | |||
** DIC<ref name="pmid27194836">{{cite journal |vauthors=Dhanapriya J, Gopalakrishnan N, Arun V, Dineshkumar T, Sakthirajan R, Balasubramaniyan T, Haris M |title=Acute kidney injury and disseminated intravascular coagulation due to mercuric chloride poisoning |journal=Indian J Nephrol |volume=26 |issue=3 |pages=206–8 |date=2016 |pmid=27194836 |pmc=4862267 |doi=10.4103/0971-4065.164230 |url=}}</ref><ref name="pmid28509280">{{cite journal |vauthors=Fukunaga S, Ishida C, Nakaoka A, Ito T |title=A case of acute kidney injury and disseminated intravascular coagulation associated with influenza B viral infection |journal=CEN Case Rep |volume=4 |issue=1 |pages=95–100 |date=May 2015 |pmid=28509280 |pmc=5413716 |doi=10.1007/s13730-014-0147-9 |url=}}</ref> | |||
** Heart failure | |||
** Cirrhosis<ref name="pmid17223500">{{cite journal |vauthors=Moreau R, Lebrec D |title=Diagnosis and treatment of acute renal failure in patients with cirrhosis |journal=Best Pract Res Clin Gastroenterol |volume=21 |issue=1 |pages=111–23 |date=2007 |pmid=17223500 |doi=10.1016/j.bpg.2006.10.004 |url=}}</ref> | |||
* '''Toxic [[acute tubular necrosis]]:'''Acute tubular necrosis can occur due to direct or indirect tubular cell cytotoxicity secondary to medications or substance exposures. | |||
** '''Exogenous nephrotoxins''': | ** '''Exogenous nephrotoxins''': | ||
*** [[Aminoglycoside|Aminoglycosides]]<ref name="pmid10223907">{{cite journal |vauthors=Mingeot-Leclercq MP, Tulkens PM |title=Aminoglycosides: nephrotoxicity |journal=Antimicrob. Agents Chemother. |volume=43 |issue=5 |pages=1003–12 |date=May 1999 |pmid=10223907 |pmc=89104 |doi= |url=}}</ref> | *** [[Aminoglycoside|Aminoglycosides]]<ref name="pmid10223907">{{cite journal |vauthors=Mingeot-Leclercq MP, Tulkens PM |title=Aminoglycosides: nephrotoxicity |journal=Antimicrob. Agents Chemother. |volume=43 |issue=5 |pages=1003–12 |date=May 1999 |pmid=10223907 |pmc=89104 |doi= |url=}}</ref> | ||
Revision as of 20:33, 3 May 2018
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Acute tubular necrosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Acute tubular necrosis causes On the Web |
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American Roentgen Ray Society Images of Acute tubular necrosis causes |
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Risk calculators and risk factors for Acute tubular necrosis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
OR
Common causes of [disease] include [cause1], [cause2], and [cause3].
OR
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
OR
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
- Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes
[Disease name] may be caused by:
- Ischemic acute tubular necrosis:
- Toxic acute tubular necrosis:Acute tubular necrosis can occur due to direct or indirect tubular cell cytotoxicity secondary to medications or substance exposures.
- Exogenous nephrotoxins:
- Aminoglycosides[8]
- Amphotericin B[9]
- Contrast media[10]
- Cisplatin[11]
- Ifosfamide[12]
- Foscarnet[13]
- Pentamidine[14]
- Cidofovir[15]
- Tenofovir [16]
- Acyclovir[17]
- Bisphosphonates[18]
- Cephalosporin[19]
- Naproxen[20]
- Tacrolimus[21]
- Mannitol[22]
- Intravenous immunoglobulins:[23] These contain sucrose which is toxic to tubular cells.
- Cyclosporine[24]
- Endogenous nephrotoxins:
- Multiple myeloma[25]: In multiple myeloma, kidney injury and renal failure is mostly caused by accumulation of light chains in renal tubules leading to obstruction as well as direct toxic effect of light chains on tubules.
- Heme pigment–associated kidney damage: Myoglobinuria and hemoglobinuria
- Traumatic or non traumatic rhabdomyolysis leads to release of myoglobin, which may cause tublar blockage, direct tubular injury and vasoconstriction.
- Hemolysis leads to hemoglobinuria.
- Crystal induced nephropathy: May be seen in association with malignancies and cytotoxic therapy[26], ethylene glycol poisoning[27] and excessive intake of vitamin C[28]
- Exogenous nephrotoxins:
Less Common Causes
Less common causes of disease name include:
- [Cause1]
- [Cause2]
- [Cause3]
Genetic Causes
- [Disease name] is caused by a mutation in the [gene name] gene.
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3References
- ↑ Basile DP, Anderson MD, Sutton TA (April 2012). "Pathophysiology of acute kidney injury". Compr Physiol. 2 (2): 1303–53. doi:10.1002/cphy.c110041. PMC 3919808. PMID 23798302.
- ↑ Ibrahim AE, Sarhane KA, Fagan SP, Goverman J (March 2013). "Renal dysfunction in burns: a review". Ann Burns Fire Disasters. 26 (1): 16–25. PMC 3741002. PMID 23966894.
- ↑ Ramoutar V, Landa C, James LR (August 2014). "Acute tubular necrosis (ATN) presenting with an unusually prolonged period of marked polyuria heralded by an abrupt oliguric phase". BMJ Case Rep. 2014. doi:10.1136/bcr-2013-201030. PMC 4154042. PMID 25150229.
- ↑ Ratcliffe PJ, Moonen CT, Holloway PA, Ledingham JG, Radda GK (September 1986). "Acute renal failure in hemorrhagic hypotension: cellular energetics and renal function". Kidney Int. 30 (3): 355–60. PMID 3784280.
- ↑ Dhanapriya J, Gopalakrishnan N, Arun V, Dineshkumar T, Sakthirajan R, Balasubramaniyan T, Haris M (2016). "Acute kidney injury and disseminated intravascular coagulation due to mercuric chloride poisoning". Indian J Nephrol. 26 (3): 206–8. doi:10.4103/0971-4065.164230. PMC 4862267. PMID 27194836.
- ↑ Fukunaga S, Ishida C, Nakaoka A, Ito T (May 2015). "A case of acute kidney injury and disseminated intravascular coagulation associated with influenza B viral infection". CEN Case Rep. 4 (1): 95–100. doi:10.1007/s13730-014-0147-9. PMC 5413716. PMID 28509280.
- ↑ Moreau R, Lebrec D (2007). "Diagnosis and treatment of acute renal failure in patients with cirrhosis". Best Pract Res Clin Gastroenterol. 21 (1): 111–23. doi:10.1016/j.bpg.2006.10.004. PMID 17223500.
- ↑ Mingeot-Leclercq MP, Tulkens PM (May 1999). "Aminoglycosides: nephrotoxicity". Antimicrob. Agents Chemother. 43 (5): 1003–12. PMC 89104. PMID 10223907.
- ↑ Fanos V, Cataldi L (December 2000). "Amphotericin B-induced nephrotoxicity: a review". J Chemother. 12 (6): 463–70. doi:10.1179/joc.2000.12.6.463. PMID 11154026.
- ↑ Lang EK, Foreman J, Schlegel JU, Leslie C, List A, McCormick P (January 1981). "The incidence of contrast medium induced acute tubular necrosis following arteriography". Radiology. 138 (1): 203–6. doi:10.1148/radiology.138.1.7455084. PMID 7455084.
- ↑ Wadd NJ, Tiplady C, Roberts JT (1997). "Cisplatin and acute tubular necrosis". Clin Oncol (R Coll Radiol). 9 (4): 267–8. PMID 9315405.
- ↑ Berns JS, Haghighat A, Staddon A, Cohen RM, Schmidt R, Fisher S, Rudnick MR, Tomaszewski JE (August 1995). "Severe, irreversible renal failure after ifosfamide treatment. A clinicopathologic report of two patients". Cancer. 76 (3): 497–500. PMID 8625132.
- ↑ Deray G, Martinez F, Katlama C, Levaltier B, Beaufils H, Danis M, Rozenheim M, Baumelou A, Dohin E, Gentilini M (1989). "Foscarnet nephrotoxicity: mechanism, incidence and prevention". Am. J. Nephrol. 9 (4): 316–21. doi:10.1159/000167987. PMID 2554731.
- ↑ Prabhavalkar S, Masengu A, O'Rourke D, Shields J, Courtney A (2013). "Nebulized pentamidine-induced acute renal allograft dysfunction". Case Rep Transplant. 2013: 907593. doi:10.1155/2013/907593. PMC 3562641. PMID 23401840.
- ↑ Ortiz A, Justo P, Sanz A, Melero R, Caramelo C, Guerrero MF, Strutz F, Müller G, Barat A, Egido J (2005). "Tubular cell apoptosis and cidofovir-induced acute renal failure". Antivir. Ther. (Lond.). 10 (1): 185–90. PMID 15751777.
- ↑ Herlitz LC, Mohan S, Stokes MB, Radhakrishnan J, D'Agati VD, Markowitz GS (December 2010). "Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities". Kidney Int. 78 (11): 1171–7. doi:10.1038/ki.2010.318. PMID 20811330.
- ↑ Izzedine H, Launay-Vacher V, Deray G (May 2005). "Antiviral drug-induced nephrotoxicity". Am. J. Kidney Dis. 45 (5): 804–17. PMID 15861345.
- ↑ Perazella MA, Markowitz GS (December 2008). "Bisphosphonate nephrotoxicity". Kidney Int. 74 (11): 1385–93. doi:10.1038/ki.2008.356. PMID 18685574.
- ↑ Longstreth KL, Robbins SD, Smavatkul C, Doe NS (June 2004). "Cephalexin-induced acute tubular necrosis". Pharmacotherapy. 24 (6): 808–11. doi:10.1592/phco.24.8.808.36069. PMID 15222673.
- ↑ Kovacevic L, Bernstein J, Valentini RP, Imam A, Gupta N, Mattoo TK (August 2003). "Renal papillary necrosis induced by naproxen". Pediatr. Nephrol. 18 (8): 826–9. doi:10.1007/s00467-003-1167-4. PMID 12774222.
- ↑ Ardalan MR, Nasri H, Ghabili K, Mohajel Shoja M (December 2008). "Acute tubular necrosis after renal allograft segmental infarction: the nephrotoxicity of necrotic material". Exp Clin Transplant. 6 (4): 312–4. PMID 19338495.
- ↑ Dorman HR, Sondheimer JH, Cadnapaphornchai P (May 1990). "Mannitol-induced acute renal failure". Medicine (Baltimore). 69 (3): 153–9. PMID 2111870.
- ↑ Fakhouri F (May 2007). "[Intravenous immunoglobulins and acute renal failure: mechanism and prevention]". Rev Med Interne (in French). 28 Spec No. 1: 4–6. PMID 17768831.
- ↑ Dussol B, Reynaud-Gaubert M, Saingra Y, Daniel L, Berland Y (October 2000). "Acute tubular necrosis induced by high level of cyclosporine A in a lung transplant". Transplantation. 70 (8): 1234–6. PMID 11063346.
- ↑ Dimopoulos MA, Kastritis E, Rosinol L, Bladé J, Ludwig H (August 2008). "Pathogenesis and treatment of renal failure in multiple myeloma". Leukemia. 22 (8): 1485–93. doi:10.1038/leu.2008.131. PMID 18528426.
- ↑ Choudhry WM, Nori US, Nadasdy T, Satoskar AA (May 2016). "An unexpected cause of acute kidney injury in a patient with ANCA associated vasculitis". Clin. Nephrol. 85 (5): 289–95. doi:10.5414/CN108760. PMID 26932179.
- ↑ Seo JW, Lee JH, Son IS, Kim YJ, Kim DY, Hwang Y, Chung HA, Choi HS, Lim SD (December 2012). "Acute oxalate nephropathy caused by ethylene glycol poisoning". Kidney Res Clin Pract. 31 (4): 249–52. doi:10.1016/j.krcp.2012.09.007. PMC 4716116. PMID 26889430.
- ↑ Cossey LN, Rahim F, Larsen CP (June 2013). "Oxalate nephropathy and intravenous vitamin C". Am. J. Kidney Dis. 61 (6): 1032–5. doi:10.1053/j.ajkd.2013.01.025. PMID 23548555.