Sandbox:Amd

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Differential diagnosis

Abbreviations:

Mechanism		Etiology	Clinical manifestations							Paraclinical findings							rowspan="3"Comments
			Physical exam							Lab findings/Urine exam
			Dysuria	Nocturia	Hematuria	Dribbling	Proteinuria		Edema	Serum osmolarity	Urine Na	Proteins	Urine osmolarity			Gold standard
Diseases			Clinical manifestations									Para-clinical findings										Gold standard	Additional findings
			Symptoms						Physical examination
												Lab Findings				Imaging			Histopathology
			Weight loss	Fever	Nausea/ Vomiting	Urinary symptoms			Hypertension	Pitting edema	Other	Serum osmolarity	Electrolytes	ADH	Urinalysis	Ultrasonography	CT scan	Other
						Dysuria	Frequency	Nocturia											Light microscopy	Electron microscopy	Immunoflourescence pattern
Increased solute excretion	Osmotic causes	Diabetes mellitus				+	+
		Mannitol
	Salt loss	Diuretics
		Cerebral salt-wasting syndrome
Impaired urinary concentration	Low ADH	Central diabetes insipidus
		Nephrogenic diabetes insipidus
	Renal disease	Renal tubular acidosis
		Bartter syndrome

POLYURIA

Mechanism		Etiology	Clinical manifestations							Paraclinical findings						Comments
			Symptoms and signs							Lab findings/Urine exam
			Serum osmolarity	Nocturia	Dysuria	Dribbling	Hematuria	Proteinuria	Edema	Urine Na	Proteins	Urine osmolarity			Gold standard
Increased intake of fluid		Psychogenic polydipsia				–	–
Increased solute excretion	Osmotic causes	Diabetes mellitus				+	+
		Mannitol
	Salt loss	Diuretics
		Cerebral salt-wasting syndrome
Impaired urinary concentration	Low ADH	Central diabetes insipidus
		Nephrogenic diabetes insipidus
	Renal disease	Renal tubular acidosis
		Bartter syndrome

Differential diagnosis

Abbreviations: AP= Anteroposterior, CXR= Chest X-ray, CT= Computed tomography, ABG= Arterial blood gas, V/Q= Ventilation/perfusion scan , EKG= Electrocardiogram, COPD= Chronic obstructive pulmonary disease, BNP= Brain natriuretic peptide, DVT= Deep vein thrombosis, HRCT= High Resolution CT, IgE= Immunoglobulin E

Causes of cyanosis Cyanosis Clinical manifestations/association Diagnosis Additional findings Symptoms Signs Peripheral Central Dyspnea Fever Chest pain Clubbing Peripheral edema Auscultation Lab Findings Imaging Gold standard Respiratory Airway disorder Severe croup ✔ − ✔ ✔ − − − Audible stridor at rest Lymphocytosis AP Neck X ray for soft tissues: Steeple sign Lateral neck X ray: Distended hypopharynx during inspiration Clinical diagnosis Croupy cough and stridor Intercostal, subcostal retractions Epiglottitis ✔ − ✔ ✔ − − − Stridor Leukocytosis with neutrophilia Blood cultures Throat culture in intubated patients Lateral neck X ray Thumbprint sign (swollen epiglottis) Laryngoscopy Sore Throat Dysphagia Odynophagia Muffled voice Drooling Foreign body aspiration ✔ − ✔ ✔ ✔ − − Decreased breath sounds Wheezing ABGs CXR Hyperinflation (children) Atelectasis (adults) Objects CT scan Foreign body Entrapment with edema or granulation tissue Bronchoscopy Complications: Inflammation Mediastinitis Local emphysema Atelectasis Cyanosis Bacterial tracheitis ✔ − ✔ ✔ ✔ − − Inspiratory stridor Blood cultures Gram stain Lateral neck X ray Confusing Steeple sign Irregular tracheal margin Laryngotracheo-bronchoscopy Brassy cough Retractions No drooling Hoarseness Disease Peripheral Central Dyspnea Fever Chest pain Clubbing Peripheral edema Auscultation Lab Findings Imaging Gold standard Additional findings Parenchymal disorder Pneumonia − ✔ ✔ ✔ ✔ ✔ − Reduced breath sounds Rales, crackles, wheeze Pleural friction rub ABGs Leukocytosis Pancytopenia Hyponatremia CXR CT chest Bronchoscopy Sputum culture and gram stain Blood cultures Urine antigen Chest X-ray Tachycardia Bradycardia (Legionella) CURB-65 Asthma (Late) − ✔ ✔ − ✔ ✔ in interstitial lung disease − End expiratory wheeze Absent wheeze and breath sounds in severe form ABG Eosinophilia IgE CXR to rule out other diagnosis complications like pneumonia, atelactasis HRCT Allergic bronchopulmonary aspergillosis Bronchiectasis Spirometry/ Pulmonary function testing Reversible obstructive disease Peak expiratory flow measurement is easy and very helpful GERD is a cause in case of refractory asthma. Triad of asthma, nasal polyps and rash is indicative of aspirin sensitivity. Cystic fibrosis ✔ − ✔ when infected ✔ ✔ − Wheeze or crackles Sputum stain and culture Sweat test Genetic test for CFTR (gene) CXR Hyperinflation Peribronchial thickening Nodules Bronchiectasis HRCT for detecting lung changes Clinical history Sweat test Usually present since birth Recurrent pneumonia Recurrent wheezing Recurrent sinusitis Gastrointestinal manifestations Meconium ileus Pancreatic insufficiency COPD (Severe emphysema) ✔ − ✔ − ✔ − ✔ Reduced breath sounds Prolonged expiration Wheeze Inspiratory crackles Hematocrit ABG Sputum staining and culture Alpha 1-antitrypsin test CXR Elongated heart Flattening of diaphragms Prominent hilar vasculature HRCT Bullae HRCT Spirometry (FEV1) to assess severity Pulmonary hypertension Right heart failure Disease Peripheral Central Dyspnea Fever Chest pain Clubbing Peripheral edema Auscultation Lab Findings Imaging Gold standard Additional findings Pulmonary vascular disorders Massive pulmonary embolism ✔ − ✔ ✔ ✔ − ✔ Reduced breath sounds Rales, crackles Loud P2 ABGs D-dimer EKG BNP CXR V/Q scan Spiral CT pulmonary angiogram Venous ultrasound for DVT Spiral CT pulmonary angiogram Ventilation/perfusion scan Tachycardia Shock Pulmonary hypertension can occur Pulmonary arterio-venous malformation − ✔ ✔ − ✔ ✔ − Pulmonary bruit CBC ABG CXR Round/oval mass lobulated well defined Connecting vessel in hilum Hemothorax Pulmonary angiography Contrast echocardiography Classic triad of dyspnea on exertion, cyanosis and clubbing Cerebral arteriovenous malformation Pregnancy can increase the size Chest wall disorders Flail chest − ✔ − − − Pneumothorax ✔ − ✔ − ✔ − − Decreased breath sounds Wheezing Cardiovascular Congenital heart diseases Disease Peripheral Central Dyspnea Fever Chest pain Clubbing Peripheral edema Auscultation Lab Findings Imaging Gold standard Additional findings Atrioventricular canal defect ✔ ✔ + ✔ + Ebstein anomaly ✔ ✔ ✔ Hypoplastic left heart syndrome ✔ ✔ Pulmonary atresia ✔ ✔ Tetralogy of Fallot ✔ ✔ ✔ Pulmonic stenosis ✔ ✔ Total anomalous pulmonary venous drainage ✔ ✔ Transposition of the great vessels ✔ ✔ Truncus arteriosus ✔ ✔ Disease Peripheral Central Dyspnea Fever Chest pain Clubbing Peripheral edema Auscultation Lab Findings Imaging Gold standard Additional findings Heart failure ✔ ✔ + − + ✔ + Valvular heart disease ✔ + − − − − Myocardial infarction ✔ ✔ − ✔ − − − Hematologic Methemoglobinemia ✔ Polycythemia ✔ Central Nervous system Disease Peripheral Central Dyspnea Fever Chest pain Clubbing Peripheral edema Auscultation Lab Findings Imaging Gold standard Additional findings Coma ✔ Seizures ✔ Head trauma ✔ Breath holding spells ✔ Miscellaneous Shock ✔ Smoke inhalation ✔ + + + Cold exposure ✔ − − − − − − − CBC Fingerstick glucose (Hyperglycemia) EKG- J wave Sinus bradycardia Prolongation of all ECG intervals. Serum electrolytes -K+ and calcium BUN and creatinine PT, PTT S. lactate ABG Mild hypothermia: core temperature 32 to 35°C ; Confusion Tachycardia Increased shivering. Moderate hypothermia: 28 to 32°C Lethargy Bradycardia Arrhythmia Decreased shivering. Severe hypothermia: <28°C Coma Hypotension Arrhythmia Pulmonary edema Rigidity Drugs† − − − − −