Acute promyelocytic leukemia risk factors: Difference between revisions
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{{Acute promyelocytic leukemia}} | {{Acute promyelocytic leukemia}} | ||
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==Acute promyelocytic leukemia risk factors== | |||
Risk factors for acute promyelocytic leukemia are similar to risk factors for [[acute myeloid leukemia]]. | |||
*'''Advanced age''': This is the most common risk factor for acute leukemia. Elderly patients are more likely to develop myeloid leukemia, due to a longer duration and opportunity for mutations to accumulate in cells. | |||
*'''Benzene'''<ref name="pmid22166497">{{cite journal| author=McHale CM, Zhang L, Smith MT| title=Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. | journal=Carcinogenesis | year= 2012 | volume= 33 | issue= 2 | pages= 240-52 | pmid=22166497 | doi=10.1093/carcin/bgr297 | pmc=3271273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22166497 }} </ref>: Benzene is a chemical solvent and aromatic hydrocarbon, for which exposure is a significant risk factor for acute leukemia.<ref name="pmid22166497">{{cite journal| author=McHale CM, Zhang L, Smith MT| title=Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. | journal=Carcinogenesis | year= 2012 | volume= 33 | issue= 2 | pages= 240-52 | pmid=22166497 | doi=10.1093/carcin/bgr297 | pmc=3271273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22166497 }} </ref> | |||
*'''Prior myelodysplastic syndrome''': [[Myelodysplastic syndrome]] is a disorder characterized by ineffective hematopoiesis, defective maturation of blood cells, and peripheral cytopenias. Antecedant [[myelodysplastic syndrome]] is implicated in some forms of acute leukemia, such as [[acute myeloid leukemia]]. | |||
*'''Germline mutations''': In general, germline predisposition to acute promyelocytic leukemia is rare. In patients with [[acute myeloid leukemia]], germline mutations in the ''RUNX1'' gene can predispose to the development of the cancer. | |||
==References== | ==References== | ||
Revision as of 05:32, 13 May 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Acute promyelocytic leukemia risk factors
Risk factors for acute promyelocytic leukemia are similar to risk factors for acute myeloid leukemia.
- Advanced age: This is the most common risk factor for acute leukemia. Elderly patients are more likely to develop myeloid leukemia, due to a longer duration and opportunity for mutations to accumulate in cells.
- Benzene[1]: Benzene is a chemical solvent and aromatic hydrocarbon, for which exposure is a significant risk factor for acute leukemia.[1]
- Prior myelodysplastic syndrome: Myelodysplastic syndrome is a disorder characterized by ineffective hematopoiesis, defective maturation of blood cells, and peripheral cytopenias. Antecedant myelodysplastic syndrome is implicated in some forms of acute leukemia, such as acute myeloid leukemia.
- Germline mutations: In general, germline predisposition to acute promyelocytic leukemia is rare. In patients with acute myeloid leukemia, germline mutations in the RUNX1 gene can predispose to the development of the cancer.
References
- ↑ 1.0 1.1 McHale CM, Zhang L, Smith MT (2012). "Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment". Carcinogenesis. 33 (2): 240–52. doi:10.1093/carcin/bgr297. PMC 3271273. PMID 22166497.