Urethral cancer pathophysiology: Difference between revisions
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==Microscopic Pathology== | ==Microscopic Pathology== | ||
* Female | * [[Female]] | ||
:* The female urethra is lined by transitional cell mucosa proximally and stratified squamous cells distally. Therefore, [[transitional cell carcinoma]] is most common in the proximal urethra and squamous cell carcinoma predominates in the distal urethra. [[Adenocarcinoma]] may occur in both locations and arises from [[metaplasia]] of the numerous periurethral glands. | :* The [[female]] [[urethra]] is lined by [[transitional cell]] mucosa proximally and stratified squamous cells distally. Therefore, [[transitional cell carcinoma]] is most common in the proximal urethra and [[Squamous cell carcinoma laboratory tests|squamous cell carcinoma]] predominates in the distal urethra. [[Adenocarcinoma]] may occur in both locations and arises from [[metaplasia]] of the numerous [[Periurethral phlegmon|periurethral]] [[glands]]. | ||
* Male | * Male | ||
Revision as of 18:39, 15 May 2018
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Urethral cancer Microchapters |
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Treatment |
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Urethral cancer pathophysiology On the Web |
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Risk calculators and risk factors for Urethral cancer pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
The pathophysiology of urethral cancer depends on the histological subtypes.
Microscopic Pathology
- The female urethra is lined by transitional cell mucosa proximally and stratified squamous cells distally. Therefore, transitional cell carcinoma is most common in the proximal urethra and squamous cell carcinoma predominates in the distal urethra. Adenocarcinoma may occur in both locations and arises from metaplasia of the numerous periurethral glands.
- Male
- The male urethra is lined by transitional cells in its prostatic and membranous portion and stratified columnar epithelium to stratified squamous epithelium in the bulbous and penile portions. The submucosa of the urethra contains numerous glands. Therefore, urethral cancer in the male can manifest the histological characteristics of transitional cell carcinoma, squamous cell carcinoma, or adenocarcinoma.
- Except for the prostatic urethra, where transitional cell carcinoma is most common, squamous cell carcinoma is the predominant histology of urethral neoplasms. Transitional cell carcinoma of the prostatic urethra may be associated with transitional cell carcinoma of the bladder and/or transitional cell carcinoma arising in prostatic ducts.