IgA nephropathy laboratory findings

IgA nephropathy Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal for patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

• There are no diagnostic laboratory findings associated with [disease name].

OR

• An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
• [Test] is usually normal among patients with [disease name].
• Laboratory findings consistent with the diagnosis of [disease name] include:
  • [Abnormal test 1]
  • [Abnormal test 2]
  • [Abnormal test 3]

• Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

Initial Evaluation

1. Assess all patients with biopsy-proven IgA nephropathy for secondary causes to rule out common causes of secondary IgA nephropathy
   1. Viral serologies: HIV, HBV, HCV
   2. Liver function tests
   3. Electrophoresis of serum immunoglobulins
2. Assess the risk of progression and prognosis by the following parameters at diagnosis and at follow-up:
   1. Blood pressure measurement
   2. Serum creatinine to estimate glomerular filtration rate (GFR)
   3. Proteinuria
   4. Pathological features

A kidney biopsy is to be considered only if signs of AKI and macroscopic hematuria persist for at least 5 days since onset of kidney injury.