IgA nephropathy laboratory findings: Difference between revisions

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{{CMG}}
{{CMG}}
==Overview==
==Overview==
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
*There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.
 
OR
 
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
 
OR
 
[Test] is usually normal for patients with [disease name].
 
OR
 
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
 
OR
 
There are no diagnostic laboratory findings associated with [disease name].


==Laboratory Findings==
==Laboratory Findings==


*There are no diagnostic laboratory findings associated with [disease name].
*There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.
OR
*Some patients with IgA nephropathy may have elevated concentration of serum total IgA.
*An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
**There is not enough evidence of serum total IgA concentration for the measurement of the severity or activity of IgA nephropathy.
*[Test] is usually normal among patients with [disease name].
*Urinary Immunoglobulins are not distinctive in IgA nephropathy.
*Laboratory findings consistent with the diagnosis of [disease name] include:
**[Abnormal test 1]
**[Abnormal test 2]
**[Abnormal test 3]
 
*Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
 
===Initial Evaluation===
===Initial Evaluation===
# Assess all patients with biopsy-proven IgA nephropathy for secondary causes to rule out common causes of secondary IgA nephropathy
# Assess all patients with biopsy-proven IgA nephropathy for secondary causes to rule out common causes of secondary IgA nephropathy
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## Pathological features
## Pathological features


A kidney biopsy is to be considered only if signs of AKI and macroscopic hematuria persist for at least 5 days since onset of kidney injury.
A kidney biopsy is to be considered only if signs of AKI and macroscopic hematuria persist for at least 5 days since the onset of kidney injury.


==References==
==References==

Revision as of 13:56, 21 May 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

  • There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.

Laboratory Findings

  • There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.
  • Some patients with IgA nephropathy may have elevated concentration of serum total IgA.
    • There is not enough evidence of serum total IgA concentration for the measurement of the severity or activity of IgA nephropathy.
  • Urinary Immunoglobulins are not distinctive in IgA nephropathy.

Initial Evaluation

  1. Assess all patients with biopsy-proven IgA nephropathy for secondary causes to rule out common causes of secondary IgA nephropathy
    1. Viral serologies: HIV, HBV, HCV
    2. Liver function tests
    3. Electrophoresis of serum immunoglobulins
  2. Assess the risk of progression and prognosis by the following parameters at diagnosis and at follow-up:
    1. Blood pressure measurement
    2. Serum creatinine to estimate glomerular filtration rate (GFR)
    3. Proteinuria
    4. Pathological features

A kidney biopsy is to be considered only if signs of AKI and macroscopic hematuria persist for at least 5 days since the onset of kidney injury.

References

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