IgA nephropathy laboratory findings

IgA nephropathy Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Dildar Hussain, MBBS [2]

Overview

• There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.

Laboratory Findings

• There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.
• Some patients with IgA nephropathy may have elevated concentration of serum total IgA.
  • There is not enough evidence of serum total IgA concentration for the measurement of the severity or activity of IgA nephropathy.
• The urinary Immunoglobulins are not distinctive in IgA nephropathy.

Initial Evaluation

• Assess all patients with biopsy-proven IgA nephropathy for secondary causes to rule out common causes of secondary IgA nephropathy
  • Viral serologies:
    • HIV
    • HBV
    • HCV
  • Liver function tests
  • Electrophoresis of serum immunoglobulins
• Assess the risk of progression and prognosis by the following parameters at diagnosis and at follow-up:
  • Blood pressure measurement
  • Serum creatinine to estimate glomerular filtration rate (GFR)
  • Proteinuria
  • Pathological features
• A kidney biopsy is to be considered only if signs of acute kidney injury and macroscopic hematuria persist for at least 5 days since the onset of kidney injury.