Renal tubular acidosis history and symptoms

Renal tubular acidosis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Renal tubular acidosis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Renal tubular acidosis history and symptoms On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Renal tubular acidosis history and symptoms All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Renal tubular acidosis history and symptoms
CDC on Renal tubular acidosis history and symptoms
Renal tubular acidosis history and symptoms in the news
Blogs on Renal tubular acidosis history and symptoms
Directions to Hospitals Treating Psoriasis
Risk calculators and risk factors for Renal tubular acidosis history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

History

The significant information that needs to focused in the history of the patient includes

• Onset of symptoms 
• Associated symptoms and signs from changes in
  • Pulmonary
  • Cardiovascular
  • Neurologic
  • Musculoskeletal function

Symptoms

The clinical manifestations of renal tubular acidosis depend upon the underlying etiology and type of acidosis.

Type of RTA
Distal renal tubular acidosis	Recessive form		Infancy	Severe hyperchloremic metabolic acidosis (serum bicarbonate levels may decrease below 10 mEq/L) Moderate to severe hypokalemia (serum potassium ≤ 3.0 mEq/L) Nephrocalcinosis Vomiting Dehydration Poor growth Rickets
	Dominant form		Adults	Common initial finding is renal stone or nephrocalcinosis Mild or no acidosis Mild to moderate hypokalemia Poor growth Bone disease CKD
Proximal renal tubular acidosis	Isolated proximal renal tubular acidosis	Transient or sporadic proximal RTA	Infants	Tachypnea Growth failure Recurrent vomiting Feeding difficulties Persistently low serum bicarbonate level
		Autosomal recessive proximal RTA	Adults	Severe hypokalemic Hyperchloremic, metabolic acidosis Growth retardation Ocular abnormalities such as glaucoma, cataracts, and band keratopathy.
		Autosomal dominant proximal RTA		Short stature Metabolic acidosis
	Fanconi syndrome			Hypophosphatemia due to phosphaturia Renal glucosuria Aminoaciduria Tubular proteinuria Growth failure Episodes of hypovolemia due to polyuria Volume depletion Bony abnormalities, including rickets and osteomalacia due to hypophosphatemia and low levels of calcitriol (1,25 dihydroxy vitamin D) Constipation and muscle weakness
Mixed renal tubular acidosis (Type 3)	Autosomal recessive		Infants	Features of both distal and proximal RTA Osteopetrosis Cerebral calcification Mental retardation Bone fragility Growth failure Facial dysmorphism Conductive hearing loss Blindness
Aldosterone deficiency or resistance (Type 4)	Resistance		Adults	Hyperkalemia, hyponatremia and mild acidosis Failure to thrive Hypotension
	Deficiency		Infants	Congenital adrenal insufficiency Aldosterone synthase deficiency Pseudohypoaldosteronism distal and 2 (also known as Gordon syndrome)

Common symptoms

Common symptoms of renal tubular acidosis include:

• Headache
• Lack of energy
• Nausea, and vomiting
• Mental confusion progressing to stupor
• Persistent tachypnea or hyperpnea to compensate
• Musculoskeletal abnormalities
  • Osteomalacia
  • Osteitis fibrosa
  • Rickets
  • O0steomalacia
  • Osteopenia