Acute tubular necrosis other diagnostic studies: Difference between revisions
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|Interleukin-18 (IL-18) | |Interleukin-18 (IL-18) | ||
| | |Elevated levels of IL-18 are found in urine after renal tubular injury. | ||
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|Kidney Injury Molecule-1 (KIM-1) | |||
|Produced by proximal tubular cells after ischaemic or nephrotoxic injury. Elevated levels are found in urine following tubular injury | |||
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|Cystatin C | |||
|Cysteine protease inhibitor filtered at the glomerulus, and reabsorbed at the proximal tubule with out secretion.Elevated levels in urine may be found after tubular insult. | |||
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|Liver-type fatty acid binding protein (L-FABP) | |||
|Produced in proximal tubular cells and in the liver. Elevated levels are found in urine following tubular injury. | |||
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|Tubular enzymes: Alpha glutathione S-transferase, pi-glutathione S-transferase, N-acetyl-beta-glucosaminidase | |||
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Revision as of 20:16, 22 May 2018
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Acute tubular necrosis Microchapters |
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Acute tubular necrosis other diagnostic studies On the Web |
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Risk calculators and risk factors for Acute tubular necrosis other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
There are no other diagnostic studies associated with [disease name].
OR
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
OR
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].
Other Diagnostic Studies
- Renal biopsy: Finding of acute tubular necrosis on renal biopsy may include:[1]
- Tubular dilatation and swollen tubular cells
- Loss of tubular cells or the denuded tubules
- Thinning of the tubular epithelium
- Loss of the cell brush border
- Edema of the interstitium
- Presence of cellular casts
- Novel biomarkers: Evaluation of various urinary and serum biomarkers may be helpful in patients with acute tubular necrosis to identify renal tubular injury at very early stage.
| BIO MARKER | PROPERTY | |
|---|---|---|
| Neutrophil gelatinase-associated lipocalin (NGAL) | ||
| Interleukin-18 (IL-18) | Elevated levels of IL-18 are found in urine after renal tubular injury. | |
| Kidney Injury Molecule-1 (KIM-1) | Produced by proximal tubular cells after ischaemic or nephrotoxic injury. Elevated levels are found in urine following tubular injury | |
| Cystatin C | Cysteine protease inhibitor filtered at the glomerulus, and reabsorbed at the proximal tubule with out secretion.Elevated levels in urine may be found after tubular insult. | |
| Liver-type fatty acid binding protein (L-FABP) | Produced in proximal tubular cells and in the liver. Elevated levels are found in urine following tubular injury. | |
| Tubular enzymes: Alpha glutathione S-transferase, pi-glutathione S-transferase, N-acetyl-beta-glucosaminidase | ||
| Retinol binding protein (RBP) | Produced by the liver and completely filtered by theglomeruli and reabsorbed, bot secreted by proximal tubular cells. It is released into urine following injury involving renal tubules. | |
References
- ↑ Tavares MB, Chagas de Almeida Mda C, Martins RT, de Sousa AC, Martinelli R, dos-Santos WL (2012). "Acute tubular necrosis and renal failure in patients with glomerular disease". Ren Fail. 34 (10): 1252–7. doi:10.3109/0886022X.2012.723582. PMC 3496189. PMID 23002699.