Renal tubular acidosis epidemiology and demographics: Difference between revisions

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==Epidemiology==
==Epidemiology==
===Incidence===
===Incidence===
* The estimated annual incidence of distal renal tubular acidosis is 10 in 100,000 population.
* Proximal renal tubular acidosis is a r
===Prevalence===
===Prevalence===
==Demographics==
* Demographics
 
===Age===
===Age===
* Renal tubular acidosis is more common in infants than other group of population
===Gender===
===Gender===
* Distal renal tubular acidosis affects men and women equally.
* However, proximal renal tubular acidosis is more common in males than females.
===Race===
===Race===
* There is racial predilection for renal tubular acidosis.
::
; •
; •
: There is no sex predominance in DRTA or in Type 4 RTA.
; •
: DRTA may be inherited as an autosomal dominant or recessive trait.
:; ○
:: Autosomal recessive DRTA often presents in infancy, whereas autosomal dominant DRTA may not present until adolescence or young adulthood.
:; ○
:: Mutations in the genes encoding carbonic anhydrase II, kidney anion exchanger 1 (kAE1), and subunits of the renal proton pump (H+‐ATPase) have been identified in patients with DRTA.
; •
: DRTA is almost always permanent.
; •
: Isolated PRTA is more common in males.
; •
: Isolated PRTA may be transient.
; •
: Genetically transmitted PRTAs include autosomal dominant and recessive forms.
; •
: PRTA (with ocular abnormalities) may be caused by inactivating mutations in the Na/HCO3 cotransporter gene (SLC4A4).
; •
: PRTA may also be associated with other genetically transmitted disorders, such as osteopetrosis with carbonic anhydrase II deficiency.
; •
: Inherited defects leading to Type 4 RTA are due to aldosterone deficiency or resistance.
:; ○
:: Congenital adrenal hyperplasia with salt wasting
:; ○
:: Isolated hypoaldosteronism
:; ○
:: Pseudohypoaldosteronism (defect at the aldosterone receptor level)


==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 16:37, 29 May 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

Epidemiology

Incidence

  • The estimated annual incidence of distal renal tubular acidosis is 10 in 100,000 population.
  • Proximal renal tubular acidosis is a r

Prevalence

  • Demographics

Age

  • Renal tubular acidosis is more common in infants than other group of population

Gender

  • Distal renal tubular acidosis affects men and women equally.
  • However, proximal renal tubular acidosis is more common in males than females.

Race

  • There is racial predilection for renal tubular acidosis.
There is no sex predominance in DRTA or in Type 4 RTA.
DRTA may be inherited as an autosomal dominant or recessive trait.
Autosomal recessive DRTA often presents in infancy, whereas autosomal dominant DRTA may not present until adolescence or young adulthood.
Mutations in the genes encoding carbonic anhydrase II, kidney anion exchanger 1 (kAE1), and subunits of the renal proton pump (H+‐ATPase) have been identified in patients with DRTA.
DRTA is almost always permanent.
Isolated PRTA is more common in males.
Isolated PRTA may be transient.
Genetically transmitted PRTAs include autosomal dominant and recessive forms.
PRTA (with ocular abnormalities) may be caused by inactivating mutations in the Na/HCO3 cotransporter gene (SLC4A4).
PRTA may also be associated with other genetically transmitted disorders, such as osteopetrosis with carbonic anhydrase II deficiency.
Inherited defects leading to Type 4 RTA are due to aldosterone deficiency or resistance.
Congenital adrenal hyperplasia with salt wasting
Isolated hypoaldosteronism
Pseudohypoaldosteronism (defect at the aldosterone receptor level)

References