|
|
| Line 8: |
Line 8: |
| ==Causes== | | ==Causes== |
| * Genetic mutations: <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq </ref> | | * Genetic mutations: <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq </ref> |
| :* Wilms tumor 1 gene (WT1)
| | ** Wilms tumor 1 gene (WT1) |
| :* WT2<ref name="pmid9441738">{{cite journal |vauthors=Crider-Miller SJ, Reid LH, Higgins MJ, Nowak NJ, Shows TB, Futreal PA, Weissman BE |title=Novel transcribed sequences within the BWS/WT2 region in 11p15.5: tissue-specific expression correlates with cancer type |journal=Genomics |volume=46 |issue=3 |pages=355–63 |date=December 1997 |pmid=9441738 |doi=10.1006/geno.1997.5061 |url=}}</ref>
| | ** WT2 |
| :* WTX<ref name="pmid17204608">{{cite journal |vauthors=Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA |title=An X chromosome gene, WTX, is commonly inactivated in Wilms tumor |journal=Science |volume=315 |issue=5812 |pages=642–5 |date=February 2007 |pmid=17204608 |doi=10.1126/science.1137509 |url=}}</ref>
| | ** WTX |
| | |
| * Other genes and chromosomal alterations: | | * Other genes and chromosomal alterations: |
| :* 1q<ref name="pmid1850292">{{cite journal |vauthors=Truong HT, Pratt EA, Ho C |title=Interaction of the membrane-bound D-lactate dehydrogenase of Escherichia coli with phospholipid vesicles and reconstitution of activity using a spin-labeled fatty acid as an electron acceptor: a magnetic resonance and biochemical study |journal=Biochemistry |volume=30 |issue=16 |pages=3893–8 |date=April 1991 |pmid=1850292 |doi= |url=}}</ref>
| | ** 1q |
| :* 16q and 1p<ref name="pmid8162576">{{cite journal |vauthors=Grundy PE, Telzerow PE, Breslow N, Moksness J, Huff V, Paterson MC |title=Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome |journal=Cancer Res. |volume=54 |issue=9 |pages=2331–3 |date=May 1994 |pmid=8162576 |doi= |url=}}</ref>
| | ** 16q and 1p |
| :* CACNA1E<ref name="pmid17189400">{{cite journal |vauthors=Natrajan R, Little SE, Reis-Filho JS, Hing L, Messahel B, Grundy PE, Dome JS, Schneider T, Vujanic GM, Pritchard-Jones K, Jones C |title=Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors |journal=Clin. Cancer Res. |volume=12 |issue=24 |pages=7284–93 |date=December 2006 |pmid=17189400 |doi=10.1158/1078-0432.CCR-06-1567 |url=}}</ref>
| | ** CACNA1E |
| :* 7p21
| | ** 7p21 |
| :* SKCG-1
| | ** SKCG-1 |
| :* TP53 (tumor suppressor gene)
| | ** TP53 (tumor suppressor gene) |
| :* FBXW7
| | ** FBXW7 |
| :* PTCH1
| | ** PTCH1 |
| :* DICER1
| | ** DICER1 |
| :* MYCN
| | ** MYCN |
| | |
| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Wilms' tumor may be caused by either genetic mutations or chromosomal alterations.
Causes
- Genetic mutations: [1]
- Wilms tumor 1 gene (WT1)
- WT2
- WTX
- Other genes and chromosomal alterations:
- 1q
- 16q and 1p
- CACNA1E
- 7p21
- SKCG-1
- TP53 (tumor suppressor gene)
- FBXW7
- PTCH1
- DICER1
- MYCN
References
Template:WH
Template:WS