Myeloproliferative neoplasm causes: Difference between revisions

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Revision as of 18:49, 9 June 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]

Overview

Myeloproliferative neoplasm is caused by mutations in various genes. Different gene mutations are responsible for each of the 8 subtypes of myeloproliferative neoplasms. ^[1]^[2]^[1]

Causes


Myeloproliferative neoplasm subtype	Causative gene mutation

Polycythemia vera	JAK2 V617F CALR MPL
Essential thrombocythemia	JAK2 V617F CALR MPL
Primary myelofibrosis	JAK2 V617F CALR MPL
Chronic myeloid leukemia	BCR-ABL SETBP1
Chronic neutrophilic leukemia	CSF3R
Chronic eosinophilic leukemia	FIL1L1-PDGFRA PDGFRB FGFR1 PCM1-JAK2
Myeloproliferative neoplasm, unclassifiable	Variable
Mastocytosis	c-kit D816V

References

↑ ^1.0 ^1.1 Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera
↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2013-11-538983 Check |pmid= value (help).

Template:WH Template:WS

[ganfyd-1] 1.0 ^1.1 Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera

[pmidhttp://dx.doi.org/10.1182/blood-2013-11-538983-2] Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2013-11-538983 Check |pmid= value (help).

[1]

[2]

@@ Line 15: / Line 15: @@
 Polycythemia vera
 | style="padding: 5px 5px; background: #F5F5F5;" |
-''JAK2'' ''V617F''
+*''JAK2'' ''V617F''
-''CALR''
+*''CALR''
-''MPL''
+*''MPL''
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 Essential thrombocythemia
 | style="padding: 5px 5px; background: #F5F5F5;" |
-''JAK2'' ''V617F''
+*''JAK2'' ''V617F''
-''CALR''
+*''CALR''
-''MPL''
+*''MPL''
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 Primary myelofibrosis
 | style="padding: 5px 5px; background: #F5F5F5;" |
-''JAK2'' ''V617F''
+*''JAK2'' ''V617F''
-''CALR''
+*''CALR''
-''MPL''
+*''MPL''
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 Chronic myeloid leukemia
 | style="padding: 5px 5px; background: #F5F5F5;" |
-''BCR-ABL''
+*''BCR-ABL''
+*''SETBP1''
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 Chronic neutrophilic leukemia
 | style="padding: 5px 5px; background: #F5F5F5;" |
-''CSF3R''
+*''CSF3R''
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 Chronic eosinophilic leukemia
 | style="padding: 5px 5px; background: #F5F5F5;" |
-''FIL1L1-PDGFRA''
+*''FIL1L1-PDGFRA''
-''PDGFRB''
+*''PDGFRB''
-''FGFR1''
+*''FGFR1''
-''PCM1-JAK2''
+*''PCM1-JAK2''
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 Myeloproliferative neoplasm, unclassifiable
 | style="padding: 5px 5px; background: #F5F5F5;" |
-Variable
+*Variable
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 Mastocytosis
 | style="padding: 5px 5px; background: #F5F5F5;" |
-''c-kit'' ''D816V''
+*''c-kit'' ''D816V''
 |}

Myeloproliferative neoplasm causes: Difference between revisions

Revision as of 18:49, 9 June 2018

Overview

Causes

References

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