Diffuse large B cell lymphoma laboratory tests: Difference between revisions

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__NOTOC__
__NOTOC__
{{Diffuse large B cell lymphoma}}
{{Diffuse large B cell lymphoma}}
{{CMG}}; {{AE}} {{AS}}
DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.
==Overview==
 
Laboratory tests of diffuse large B cell lymphoma include [[complete blood count]], blood chemistry studies, [[flow cytometry]], [[immunohistochemistry]], [[cytology]], [[genetic testing]], and [[immunophenotyping]].
Laboratory tests of diffuse large B cell lymphoma include:<ref name="”seer”">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref><ref name="”seer”">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>
==Laboratory Tests==
Laboratory tests of diffuse large B cell lymphoma include:<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref><ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>
* [[Complete blood count]] (CBC)
* [[Complete blood count]] (CBC)
* Blood chemistry studies
* Blood chemistry studies
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:*Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]''/''TTFn'', ''[[TP53]]'' genes  
:*Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]''/''TTFn'', ''[[TP53]]'' genes  
:*Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes
:*Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes
* [[Immunophenotyping]] ''BCL-2+'', ''BCL6+/-'', [[CD10]]+, [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent
* [[Immunophenotyping]] ''BCL-2+'', ''BCL6+/-'', MYC, CD5, [[CD10]]+, [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, P53, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent


==References==
==References==

Revision as of 18:13, 11 June 2018

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DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.

Laboratory tests of diffuse large B cell lymphoma include:[1][1]

  • 8q24/MYC translocations
  • Immunoglobulin genes clonally rearranged and hypermutated
  • Mutation of BCL6, MYC, PAX5, PIM1, RhoH/TTFn, TP53 genes
  • Translocations involving c-MYC, BCL6, and IgH genes

References

  1. ↑ 1.0 1.1 National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov


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