Diffuse large B cell lymphoma laboratory tests: Difference between revisions

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* [[Cytology]] (for primary CNS lymphoma only)
* [[Cytology]] (for primary CNS lymphoma only)
* [[Genetic testing]]
* [[Genetic testing]]
:*8q24/''MYC'' [[translocations]]  
** 8q24/''MYC'' [[translocations]]
:*Immunoglobulin genes clonally rearranged and hypermutated  
** Immunoglobulin genes clonally rearranged and hypermutated
:*Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]''/''TTFn'', ''[[TP53]]'' genes  
** Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]''/''TTFn'', ''[[TP53]]'' genes
:*Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes
** Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes
* [[Immunophenotyping]] ''BCL-2+'', ''BCL6+/-'', MYC, CD5, [[CD10]]+, [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, P53, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent
 
* [[Immunophenotyping]]  
** ''BCL-2+'', ''BCL6+/-'', MYC, CD5, [[CD10]]+, [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, P53, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent
* Screening tests for HIV, HBV and HCV are recommended.


==References==
==References==

Revision as of 18:46, 11 June 2018

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DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.

Laboratory tests of diffuse large B cell lymphoma include:[1]

References

  1. ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov


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