Diffuse large B cell lymphoma laboratory tests: Difference between revisions

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Laboratory tests of diffuse large B cell lymphoma include:<ref name="”seer”">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>
Laboratory tests of diffuse large B cell lymphoma include:<ref name="”seer”">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>
* [[Complete blood count]] (CBC)
* [[Complete blood count]] (CBC)
* Blood chemistry studies including LDH and Uric acid
* [[Comprehensive metabolic panel]]
* [[Flow cytometry]]
* Blood chemistry studies including [[Lactate dehydrogenase|LDH]] and [[Uric acid]]
* [[Immunohistochemistry]]
* [[Immunohistochemistry]](IHC)
** CD20, CD3, CD5, CD45, CD10, BCL-2, BCl-6, MYC, IRF-4/ MUM-1, Ki-67
* [[Flow Cytometry|Flow Cytometry Panel]] (Establishing Reliable Diagnosis require IHC with or without Flow cytometry)
** Kappa/ Lambda, CD3, CD5, CD45, CD10, CD19, CD20
* IHC for DLBCL subtypes:
** Kappa/ Lambda, CD30, CD138, Cyclin/D1, ALK, HHV-8, SOX-11, EBER-ISH
* [[Cytology]] (for primary CNS lymphoma only)
* [[Cytology]] (for primary CNS lymphoma only)
* [[Genetic testing]]
* [[Genetic testing]]
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** Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes
** Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes


* [[Immunophenotyping]]
* Screening tests for HCV and HBV ( to assess risk of Reactivation following immunotherapy/ chemotherapy) are recommended.
** ''BCL-2+'', ''BCL6+/-'', MYC, CD5, [[CD10]]+, [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, P53, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent
* Screening test for HIV
* Screening tests for HIV, HBV and HCV are recommended.


==References==
==References==

Revision as of 13:41, 17 June 2018

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DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.

Laboratory tests of diffuse large B cell lymphoma include:[1]

  • Screening tests for HCV and HBV ( to assess risk of Reactivation following immunotherapy/ chemotherapy) are recommended.
  • Screening test for HIV

References

  1. ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov


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