Myeloproliferative neoplasm causes: Difference between revisions
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Essential thrombocythemia | Essential thrombocythemia | ||
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*''JAK2'' ''V617F'' in 50-60% of cases | *''JAK2'' ''V617F'' in 50-60% of cases<ref name="pmid20418246">{{cite journal| author=Antonioli E, Carobbio A, Pieri L, Pancrazzi A, Guglielmelli P, Delaini F et al.| title=Hydroxyurea does not appreciably reduce JAK2 V617F allele burden in patients with polycythemia vera or essential thrombocythemia. | journal=Haematologica | year= 2010 | volume= 95 | issue= 8 | pages= 1435-8 | pmid=20418246 | doi=10.3324/haematol.2009.021444 | pmc=2913097 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20418246 }} </ref> | ||
*''CALR'' | *''CALR'' | ||
*''MPL'' | *''MPL'' | ||
Revision as of 18:10, 19 June 2018
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Myeloproliferative Neoplasm Microchapters |
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Differentiating myeloproliferative neoplasm from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Myeloproliferative neoplasm causes On the Web |
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American Roentgen Ray Society Images of Myeloproliferative neoplasm causes |
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Directions to Hospitals Treating Myeloproliferative neoplasm |
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Risk calculators and risk factors for Myeloproliferative neoplasm causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Myeloproliferative neoplasm is caused by mutations in various genes. Different gene mutations are responsible for each of the 8 subtypes of myeloproliferative neoplasms. [1][2][1]
Causes
| Myeloproliferative neoplasm subtype | Causative gene mutation |
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Polycythemia vera |
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Essential thrombocythemia |
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Primary myelofibrosis |
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Chronic myeloid leukemia |
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Chronic neutrophilic leukemia |
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Chronic eosinophilic leukemia |
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Myeloproliferative neoplasm, unclassifiable |
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Mastocytosis |
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References
- ↑ 1.0 1.1 Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2013-11-538983 Check
|pmid=value (help). - ↑ Antonioli E, Carobbio A, Pieri L, Pancrazzi A, Guglielmelli P, Delaini F; et al. (2010). "Hydroxyurea does not appreciably reduce JAK2 V617F allele burden in patients with polycythemia vera or essential thrombocythemia". Haematologica. 95 (8): 1435–8. doi:10.3324/haematol.2009.021444. PMC 2913097. PMID 20418246.