Myeloproliferative neoplasm other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies for myeloproliferative neoplasm include [[bone marrow aspiration]] and [[biopsy|trephine biopsy]], [[lumbar puncture]], and [[lymph node biopsy]]. | Other diagnostic studies for myeloproliferative neoplasm include [[bone marrow aspiration]] and [[biopsy|trephine biopsy]], [[lumbar puncture]], and [[lymph node biopsy]]. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Other diagnostic studies for myeloproliferative neoplasm include bone marrow aspiration and trephine biopsy, lumbar puncture, and lymph node biopsy.
Other diagnostic studies
Other diagnostic studies for myeloproliferative neoplasm include:[1][2]
- Bone marrow aspiration and trephine biopsy: This is an invasive diagnostic procedure that is sometimes required for the diagnosis of myeloproliferative neoplasm. Bone marrow biopsy usually shows high proportions of leukocytes, erythrocytes, and thrombocytes. This is referred to as panmyelosis. These findings on a bone marrow biopsy constitute one of the major diagnostic criteria for various subtypes of myeloproliferative neoplasm in the 2016 WHO classification.[3]
- Erythropoietin level: Erythropoietin level is usually low in polycythemia vera, one of the subtypes of myeloproliferative neoplasm. This is because polycythemia vera is characterized by autonomous production of red blood cells in an erythropoietin-independent manner.
- Lumbar puncture
- Used to detect any metastasis to the cerebral spinal fluid (CSF)
- Used to detect and/or determine the type of leukemic cells
Gallery
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![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/images/e/e4/CDR554337-274.jpg)
Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]
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Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]
![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/index.php/File:CDR554337-274.jpg)
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates. Dacie & Lewis Practical Haematology. London: W B Saunders. p. 586. ISBN 0-443-06377-X.
- ↑ Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM; et al. (2016). "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): 2391–405. doi:10.1182/blood-2016-03-643544. PMID 27069254.
- ↑ 4.0 4.1 National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq