Interstitial nephritis history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Interstitial nephritis}} | {{Interstitial nephritis}} | ||
{{CMG}}{{M.B}} | {{CMG}} {{AE}}{{M.B}} | ||
== Overview == | == Overview == | ||
The majority of patients with AIN from any cause are asymptomatic | The majority of patients with AIN from any cause are [[asymptomatic]]; however, vague [[Sign and symptom|signs and symptoms]] of [[acute kidney injury]] may present. | ||
symptoms of | Nevertheless, presence of symptoms or signs of a [[hypersensitivity reaction]], such as [[rash]], [[fever]], and [[eosinophilia]] in the history of consumption of the culprit drugs causing AIN should raise the clinical suspicion for drug-induced AIN. | ||
==History and Symptoms== | |||
* The majority of patients with AIN are asymptomatic. | |||
OR | |||
* The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. | |||
* Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. | |||
=== History[edit | edit source] === | |||
Patients with [disease name]] may have a positive history of: | |||
* [History finding 1] | |||
* [History finding 2] | |||
* [History finding 3] | |||
=== Common Symptoms[edit | edit source] === | |||
Common symptoms of [disease] include: | |||
* [Symptom 1] | |||
At times there are no symptoms of this disease, but when they do occur they are widely varied and can occur rapidly or gradually.<ref name="pmid11473672">{{cite journal |author=Rossert J |title=Drug-induced acute interstitial nephritis |journal=Kidney Int |volume=60 |issue=2 |pages=804-17 |year=2001 |pmid=11473672 | url=http://www.nature.com/ki/journal/v60/n2/full/4492487a.html | doi=10.1046/j.1523-1755.2001.060002804.x}}</ref><ref name="pmid14671029">.</ref><ref name="pmid6604293">{{cite journal |author=Pusey C, Saltissi D, Bloodworth L, Rainford D, Christie J |title=Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy |journal=Q J Med |volume=52 |issue=206 |pages=194-211 |year=1983 |pmid=6604293}}</ref><ref name="pmid3779558">{{cite journal |author=Handa S |title=Drug-induced acute interstitial nephritis: report of 10 cases |journal=CMAJ |volume=135 |issue=11 |pages=1278-81 |year=1986 |pmid=3779558}}</ref><ref name="pmid2113219">{{cite journal |author=Buysen J, Houthoff H, Krediet R, Arisz L |title=Acute interstitial nephritis: a clinical and morphological study in 27 patients |journal=Nephrol Dial Transplant |volume=5 |issue=2 |pages=94-9 |year=1990 |pmid=2113219}}</ref> When caused by an allergic reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients),<ref name="pmid14671029">.</ref> rash (15% of patients),<ref name="pmid14671029">.</ref> and enlarged kidneys. Some people experience [[dysuria]], and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include [[hyperkalemia]], [[metabolic acidosis]], and [[kidney failure]]. | At times there are no symptoms of this disease, but when they do occur they are widely varied and can occur rapidly or gradually.<ref name="pmid11473672">{{cite journal |author=Rossert J |title=Drug-induced acute interstitial nephritis |journal=Kidney Int |volume=60 |issue=2 |pages=804-17 |year=2001 |pmid=11473672 | url=http://www.nature.com/ki/journal/v60/n2/full/4492487a.html | doi=10.1046/j.1523-1755.2001.060002804.x}}</ref><ref name="pmid14671029">.</ref><ref name="pmid6604293">{{cite journal |author=Pusey C, Saltissi D, Bloodworth L, Rainford D, Christie J |title=Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy |journal=Q J Med |volume=52 |issue=206 |pages=194-211 |year=1983 |pmid=6604293}}</ref><ref name="pmid3779558">{{cite journal |author=Handa S |title=Drug-induced acute interstitial nephritis: report of 10 cases |journal=CMAJ |volume=135 |issue=11 |pages=1278-81 |year=1986 |pmid=3779558}}</ref><ref name="pmid2113219">{{cite journal |author=Buysen J, Houthoff H, Krediet R, Arisz L |title=Acute interstitial nephritis: a clinical and morphological study in 27 patients |journal=Nephrol Dial Transplant |volume=5 |issue=2 |pages=94-9 |year=1990 |pmid=2113219}}</ref> When caused by an allergic reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients),<ref name="pmid14671029">.</ref> rash (15% of patients),<ref name="pmid14671029">.</ref> and enlarged kidneys. Some people experience [[dysuria]], and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include [[hyperkalemia]], [[metabolic acidosis]], and [[kidney failure]]. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohsen Basiri M.D.
Overview
The majority of patients with AIN from any cause are asymptomatic; however, vague signs and symptoms of acute kidney injury may present.
Nevertheless, presence of symptoms or signs of a hypersensitivity reaction, such as rash, fever, and eosinophilia in the history of consumption of the culprit drugs causing AIN should raise the clinical suspicion for drug-induced AIN.
History and Symptoms
- The majority of patients with AIN are asymptomatic.
OR
- The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
- Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History[edit | edit source]
Patients with [disease name]] may have a positive history of:
- [History finding 1]
- [History finding 2]
- [History finding 3]
Common Symptoms[edit | edit source]
Common symptoms of [disease] include:
- [Symptom 1]
At times there are no symptoms of this disease, but when they do occur they are widely varied and can occur rapidly or gradually.[1][2][3][4][5] When caused by an allergic reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients),[2] rash (15% of patients),[2] and enlarged kidneys. Some people experience dysuria, and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include hyperkalemia, metabolic acidosis, and kidney failure.
References
- ↑ Rossert J (2001). "Drug-induced acute interstitial nephritis". Kidney Int. 60 (2): 804–17. doi:10.1046/j.1523-1755.2001.060002804.x. PMID 11473672.
- ↑ 2.0 2.1 2.2 .
- ↑ Pusey C, Saltissi D, Bloodworth L, Rainford D, Christie J (1983). "Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy". Q J Med. 52 (206): 194–211. PMID 6604293.
- ↑ Handa S (1986). "Drug-induced acute interstitial nephritis: report of 10 cases". CMAJ. 135 (11): 1278–81. PMID 3779558.
- ↑ Buysen J, Houthoff H, Krediet R, Arisz L (1990). "Acute interstitial nephritis: a clinical and morphological study in 27 patients". Nephrol Dial Transplant. 5 (2): 94–9. PMID 2113219.