Hypernatremia differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aida Javanbakht, M.D.

Overview

Hypernatremia must be differentiated from other diseases that cause

References

Disease	Clinical manifestations								Paraclinical Findings
	Symptoms and Signs								Lab Findings
	Confusion/ Irritable	Urine output	Vomiting/ Diarrhea	Volume status	Seizure	Blood pressure	Dry mucous membranes	Other
									Urine Osm	Serum Na	Other
Central diabetes insipidus	+	Polyuria	-	Hypovolemic	+	Could be high	+	-	<250 mOsm/kg	May be >170 mEq/L	Low arginin vasopressin level
Hyperosmolar hyperglycemic	+	Polyuria	-	Hypovolemic	+	Could be low	+	Abdominal pain	Could be normal	May be >145 mEq/L	Elevated serum glucose level and creatinine
Nephrogenic diabetes insipidus	+	Polyuria	-	Hypovolemic	+	Could be low	+	History of taking Gentamicin, Lithium, Rifampin	<250 mOsm/kg	May be >170 mEq/L	Desmopressin stimulation test: Not significant change in urine osmolality
GI loss (like diarrhea)	+	Oligouria	+	Hypovolemic	+	Could be low	+	History of contact with infected food or peaople	<250 mOsm/kg	May be >145 mEq/L	Desmopressin stimulation test: Not significant change in urine osmolality
Crohn (intestinal fistula)	-	Normal	Could be +	Normal	-	Normal	+	-	<250 mOsm/kg	May be >145 mEq/L	Cobblestone mucosa in colonoscopy
Heat strock	+	oligouria	-	Hypovolemic	+	Could be low	+	Suken eye, Sweating	>250 mOsm/kg	May be >145 mEq/L	Hypokalemia