Membranous glomerulonephritis overview

Membranous glomerulonephritis Microchapters
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Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Membranous glomerulonephritis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Historical Perspective

• Membranous glomerulonephritis was first discovered by David Jones, renal pathologist from Syracuse University in New York, in 1957.

Classification

• There is no established system for the classification of MGN. however it can be divided in two groups based on etiology of MGN.

Pathophysiology

• It is thought that MGN is mediated by genetic factors and environmental factors.

Causes

• The main causes of Membranous Glomerulonephritis are Infectious causes like Hepatitis B, drugs like captopril and autoimmune diseases like systemic lupus erythematosus.

Differentiating Hereditary pancreatitis from Other Diseases

• MGN must be differentiated from other diseases that cause proteinuria, weight loss, and renal failure, such as MPGN, MCD, and FSGC.

Epidemiology and Demographics

• The Incidence rate of Membranous Glomerulonephritis is 27 per 100.000.
• The Prevalence rate of Membranous Glomerulonephritis is 690 per 100,000

Risk Factors

• The most potent risk factor in the development of [disease name] is drugs. Other risk factors include penicilliamine and captopril.

Screening

• There is insufficient evidence to recommend routine screening for membranous glomerulonephritis.

Natural History, Complications, and Prognosis

• Common complications of membranous glomerulonephritis include renal failure.

Diagnosis

Diagnostic Criteria

• The most efficient and sensitive test is ANA, ds-DNA antibodies specific test that is utilized for diagnosis of membranous glomerulonephritis.
• The gold standard test for the diagnosis of biopsy.

History and Symptoms

• The hallmark of membranous glomerulonephritis is nephrotic syndrome. A positive history of forthy urine and headache are suggestive of membranous glomerulonephritis.

Physical Examination

• Common physical examination findings of membranous glomerulonephritis include edematous feets and headache.

Laboratory Findings

• The major laboratory workup includes blood workup, auto-immune workup and urine workup.

Electrocardiogram

• There are no ECG findings associated with membranous glomerulonephritis.

References

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