Interstitial nephritis causes: Difference between revisions
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==Causes== | ==Causes== | ||
===Drugs === | ===Drugs === | ||
* 70 to 75 percent (with antibiotics responsible for 30 to 49 percent of these cases) | |||
* Any drug has potentiality to cause AIN, among case reports of many drugs causing AIN, but only a few have been reported with biopsy-proven AIN. The most common proven drugs cause of AIN include: | |||
* Nonsteroidal anti-inflammatory agents (NSAIDs) | * Nonsteroidal anti-inflammatory agents (NSAIDs) | ||
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* Rifampin | * Rifampin | ||
* Diuretics, including loop diuretics such as furosemide and bumetanide, and | * Diuretics, including loop diuretics such as furosemide and bumetanide, and | ||
* | * Thiazide-type diuretics | ||
* Ciprooxacin and, perhaps to a lesser degree, ● other quinolones | * Ciprooxacin and, perhaps to a lesser degree, ● other quinolones | ||
* Cimetidine | * Cimetidine | ||
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=== <big>'''Infections'''</big> === | === <big>'''Infections'''</big> === | ||
Multiple organisms may cause TIN | Multiple organisms may cause TIN including bacterial viral fungal parasitic infections. | ||
==== Bacteria ==== | ==== Bacteria ==== | ||
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==== Virus ==== | ==== Virus ==== | ||
* | * Cytomegalovirus (CMV) | ||
* Epstein-Barr virus (EBV), | * Epstein-Barr virus (EBV), | ||
* | * Aolyomavirus, | ||
* | * Adenovirus, | ||
* Candida | * Candida | ||
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=== Immunologic diseases === | === Immunologic diseases === | ||
Sarcoidosis | * Sarcoidosis | ||
SLE, | * SLE, | ||
Sjögren's syndrome | * Sjögren's syndrome | ||
=== Tubulointerstitial nephritis and uveitis (TINU) syndrome – 5 to 10 percent === | === Tubulointerstitial nephritis and uveitis (TINU) syndrome – 5 to 10 percent === | ||
Revision as of 20:25, 17 July 2018
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Interstitial nephritis Microchapters |
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Interstitial nephritis causes On the Web |
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American Roentgen Ray Society Images of Interstitial nephritis causes |
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Risk calculators and risk factors for Interstitial nephritis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohsen Basiri M.D.
Overview
Common causes of interstitial nephritis include drug side effects, particularly analgesics and antibiotics. Other common causes include associated nephrologic conditions, as well as microbial infections.
Causes
Drugs
- 70 to 75 percent (with antibiotics responsible for 30 to 49 percent of these cases)
- Any drug has potentiality to cause AIN, among case reports of many drugs causing AIN, but only a few have been reported with biopsy-proven AIN. The most common proven drugs cause of AIN include:
- Nonsteroidal anti-inflammatory agents (NSAIDs)
- Penicillins and cephalosporins
- Antimicrobial sulfonamides, including trimethoprim-sulfamethoxazole
- Rifampin
- Diuretics, including loop diuretics such as furosemide and bumetanide, and
- Thiazide-type diuretics
- Ciprooxacin and, perhaps to a lesser degree, ● other quinolones
- Cimetidine
- Allopurinol
- Proton pump inhibitors such as omeprazole and lansoprazole
- Indinavir
- 5-aminosalicylates (eg, mesalamine)
Infections
Multiple organisms may cause TIN including bacterial viral fungal parasitic infections.
Bacteria
- Legionella,
- Leptospira,
- Streptococcus,
- Mycobacterium tuberculosis,
- Corynebacterium diphtheriae
- Yersinia,
- Enterococcus
- Escherichia coli
Virus
- Cytomegalovirus (CMV)
- Epstein-Barr virus (EBV),
- Aolyomavirus,
- Adenovirus,
- Candida
parasites
- Leishmania
- Toxoplasma
Immunologic diseases
- Sarcoidosis
- SLE,
- Sjögren's syndrome
Tubulointerstitial nephritis and uveitis (TINU) syndrome – 5 to 10 percent
Less Common Causes
Less common causes of TIN include:
- Heavy metals (eg, lead, cadmium, mercury)
- Obstructive uropathy, nephrolithiasis, reflux disease
- Neoplasia (eg, myeloma, leukemia, amyloidosis)
- Metabolic diseases (eg, hypercalcemia, cystinosis, potassium depletion, hyperoxaluria)
Causes in Alphabetical Order
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