Membranous glomerulonephritis diagnostic study of choice: Difference between revisions
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== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
=== Gold standard/Study of choice: === | === Gold standard/Study of choice: === | ||
* Biopsy is the gold standard test for the diagnosis of membranous glomerulonephritis<ref name="pmid27777266">{{cite journal |vauthors=De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC |title=A Proposal for a Serology-Based Approach to Membranous Nephropathy |journal=J. Am. Soc. Nephrol. |volume=28 |issue=2 |pages=421–430 |date=February 2017 |pmid=27777266 |pmc=5280030 |doi=10.1681/ASN.2016070776 |url=}}</ref> | * [[Biopsy]] is the gold standard test for the diagnosis of membranous glomerulonephritis<ref name="pmid27777266">{{cite journal |vauthors=De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC |title=A Proposal for a Serology-Based Approach to Membranous Nephropathy |journal=J. Am. Soc. Nephrol. |volume=28 |issue=2 |pages=421–430 |date=February 2017 |pmid=27777266 |pmc=5280030 |doi=10.1681/ASN.2016070776 |url=}}</ref> | ||
* The complete [[blood]] count, urinalysis, 24 hour [[Urine culture|urine]] collection should be performed when: | * The complete [[blood]] count, [[urinalysis]], 24 hour [[Urine culture|urine]] collection should be performed when: | ||
** ''The patient presented with signs of proteinurea and hypertension'' | ** ''The patient presented with signs of proteinurea and hypertension'' | ||
** ''A positive test is detected in the patient'' | ** ''A positive test is detected in the patient'' | ||
* Biopsy is the gold standard test for the diagnosis of membranous glomerulonephritis | * [[Biopsy]] is the gold standard test for the diagnosis of membranous glomerulonephritis | ||
'''The diagnostic study of choice for membranous glomerulonephritis is:''' | '''The diagnostic study of choice for membranous glomerulonephritis is:''' | ||
* Biopsy<ref name="pmid27777266">{{cite journal |vauthors=De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC |title=A Proposal for a Serology-Based Approach to Membranous Nephropathy |journal=J. Am. Soc. Nephrol. |volume=28 |issue=2 |pages=421–430 |date=February 2017 |pmid=27777266 |pmc=5280030 |doi=10.1681/ASN.2016070776 |url=}}</ref> | * [[Biopsy]]<ref name="pmid27777266">{{cite journal |vauthors=De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC |title=A Proposal for a Serology-Based Approach to Membranous Nephropathy |journal=J. Am. Soc. Nephrol. |volume=28 |issue=2 |pages=421–430 |date=February 2017 |pmid=27777266 |pmc=5280030 |doi=10.1681/ASN.2016070776 |url=}}</ref> | ||
===== Diagnostic Test: ===== | ===== Diagnostic Test: ===== | ||
* Biopsy is confirmatory of membranous glomerulonephritis<ref name="pmid27777266">{{cite journal |vauthors=De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC |title=A Proposal for a Serology-Based Approach to Membranous Nephropathy |journal=J. Am. Soc. Nephrol. |volume=28 |issue=2 |pages=421–430 |date=February 2017 |pmid=27777266 |pmc=5280030 |doi=10.1681/ASN.2016070776 |url=}}</ref> | * [[Biopsy]] is confirmatory of membranous glomerulonephritis<ref name="pmid27777266">{{cite journal |vauthors=De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC |title=A Proposal for a Serology-Based Approach to Membranous Nephropathy |journal=J. Am. Soc. Nephrol. |volume=28 |issue=2 |pages=421–430 |date=February 2017 |pmid=27777266 |pmc=5280030 |doi=10.1681/ASN.2016070776 |url=}}</ref> | ||
===== Sequence of Diagnostic Studies ===== | ===== Sequence of Diagnostic Studies ===== | ||
Revision as of 22:27, 18 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]
Overview
The most efficient and sensitive test is ANA, ds-DNA antibodies specific test that is utilized for diagnosis of membranous glomerulonephritis. The gold standard test for the diagnosis of biopsy.
Diagnostic Study of Choice
Gold standard/Study of choice:
- The complete blood count, urinalysis, 24 hour urine collection should be performed when:
- The patient presented with signs of proteinurea and hypertension
- A positive test is detected in the patient
- Biopsy is the gold standard test for the diagnosis of membranous glomerulonephritis
The diagnostic study of choice for membranous glomerulonephritis is:
Diagnostic Test:
Sequence of Diagnostic Studies
The urinalysis and comprehensive chemistry panel should be performed when:[2]
- The patient presented with signs of hypertension and proteinurea
- A positive ANA, anti dsDNA is detected in the patient, to confirm the diagnosis
Diagnostic Criteria
- There are no established criteria for the diagnosis of membranous glomerulonephritis
References
- ↑ 1.0 1.1 1.2 De Vriese AS, Glassock RJ, Nath KA, Sethi S, Fervenza FC (February 2017). "A Proposal for a Serology-Based Approach to Membranous Nephropathy". J. Am. Soc. Nephrol. 28 (2): 421–430. doi:10.1681/ASN.2016070776. PMC 5280030. PMID 27777266.
- ↑ Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z (June 2011). "Anti-phospholipase A2 receptor antibody in membranous nephropathy". J. Am. Soc. Nephrol. 22 (6): 1137–43. doi:10.1681/ASN.2010090967. PMC 3103733. PMID 21566055.