Lupus nephritis causes: Difference between revisions
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== Overview == | |||
==Overview== | There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include [[genetic]]<nowiki/>predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common factors include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]] | ||
== Causes == | |||
* [[Genetic]] predisposition: | |||
** [[HLA]] class [[polymorphism]] | |||
** [[Complement]] genes | |||
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | |||
* [[Auto-immune]] disease | |||
* Infections | |||
** [[Parvovirus B19]] | |||
** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | |||
** [[Trypanosomiasis]] | |||
** [[Mycobacterial infection|Mycobacterial infections]] | |||
* Exposure to [[ultraviolet]] (UV) light | |||
** Can exacerbate or induce systemic manifestations of SLE | |||
* Drug-induced lupus | |||
* [[Acebutolol]] | |||
* [[Adalimumab]] | |||
* [[Anastrozole]] | |||
* [[Bupropion]] | |||
* [[Captopril]] | |||
* [[Cilazapril]] | |||
* [[Cinnarizine]]/[[thiethylperazine]] | |||
* [[Diltiazem]] | |||
* | * [[Docetaxel]] | ||
* | * [[Doxorubicin]] | ||
*[ | * [[Penicillamine|D-penicillamine]] | ||
* [[Etanercept]] | |||
* [[Gemcitabine]] | |||
[ | * [[Glyburide]] | ||
*[ | ** [[Golimumab]] | ||
*[ | ** [[Griseofulvin]] | ||
*[ | ** [[Hydrochlorothiazide]] | ||
** [[Infliximab]] | |||
** [[Interferon-alpha]] | |||
** [[Interferon-beta]] | |||
** [[Oxprenolol]] | |||
** [[Phenytoin]] | |||
*[ | ** [[Lamotrigine]] | ||
*[ | ** [[Lansoprazole]] | ||
** [[Leflunomide]] | |||
** [[Leuprorelin]] | |||
** [[Naproxen]] | |||
*[ | ** [[Nifedipine]] | ||
*[ | ** [[Nitrendipine]] | ||
*[ | ** [[Omeprazole]] | ||
** [[Paclitaxel]] | |||
** [[Pantoprazole]] | |||
*[ | ** [[Piroxicam]] | ||
** [[Pravastatin]] | |||
** [[Ranitidine]] | |||
** [[Simvastatin]] | |||
** [[Spironolactone]] | |||
** [[Tamoxifen]] | |||
** [[Terbinafine]] | |||
** [[Ticlopidine]] | |||
** [[Verapamil]] | |||
** [[Sulfonamide|Sulfonamides]] | |||
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==References== | ==References== |
Revision as of 20:17, 19 July 2018
Overview
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include geneticpredisposition, auto-immune diseases, and use of drugs. Less common factors include environmental factors and exposure to ultraviolet (UV) light.
Causes
- Genetic predisposition:
- HLA class polymorphism
- Complement genes
- Female sexual gene due to high levels of estrogen and prolactin
- Auto-immune disease
- Exposure to ultraviolet (UV) light
- Can exacerbate or induce systemic manifestations of SLE
- Drug-induced lupus
- Acebutolol
- Adalimumab
- Anastrozole
- Bupropion
- Captopril
- Cilazapril
- Cinnarizine/thiethylperazine
- Diltiazem
- Docetaxel
- Doxorubicin
- D-penicillamine
- Etanercept
- Gemcitabine
- Glyburide
- Golimumab
- Griseofulvin
- Hydrochlorothiazide
- Infliximab
- Interferon-alpha
- Interferon-beta
- Oxprenolol
- Phenytoin
- Lamotrigine
- Lansoprazole
- Leflunomide
- Leuprorelin
- Naproxen
- Nifedipine
- Nitrendipine
- Omeprazole
- Paclitaxel
- Pantoprazole
- Piroxicam
- Pravastatin
- Ranitidine
- Simvastatin
- Spironolactone
- Tamoxifen
- Terbinafine
- Ticlopidine
- Verapamil
- Sulfonamides