Myoglobinuria: Difference between revisions
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Revision as of 09:14, 27 July 2018
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| Model of helical domains in myoglobin. |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya Stevasarova, M.D.; Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2]
Overview
Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction.
- Myoglobin (Mb or MB) is an iron- and oxygen-binding protein found in muscles. Myoglobin is present in muscle cells as a reserve of oxygen.In humans, myoglobin is only found in the bloodstream after muscle injury. It is an abnormal finding, and can be diagnostically relevant when found in blood.[1]
- Myoglobin is the primary oxygen-carrying pigment of muscle tissues.[2] High concentrations of myoglobin in muscle cells allow organisms to hold their breath for a longer period of time. Diving mammals such as whales and seals have muscles with particularly high abundance of myoglobin.[1] Myoglobin is found in Type I muscle, Type II A and Type II B, but most texts consider myoglobin not to be found in smooth muscle.
References
- ↑ 1.0 1.1 Nelson DL, Cox MM (2000). Lehninger Principles of Biochemistry (3rd ed.). New York: Worth Publishers. p. 206. ISBN 0-7167-6203-X. (Google books link is the 2008 edition)
- ↑ Ordway GA, Garry DJ (Sep 2004). "Myoglobin: an essential hemoprotein in striated muscle". The Journal of Experimental Biology. 207 (Pt 20): 3441–6. doi:10.1242/jeb.01172. PMID 15339940.
Historical Perspective
References
Classification
Pathophysiology
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Differentiating Lead poisoning from other Diseases
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