Chronic myelogenous leukemia risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
The most potent risk factor in the development of chronic myelogenous leukemia is [[ionizing radiation]]; for example, increased rates of CML were seen in people exposed to the atomic bombings of Hiroshima and Nagasaki. Other risk factors include older age, being male, [[formaldehyde]], [[obesity]], and [[smoking]].<ref name="pmid3477299">{{cite journal| author=Moloney WC| title=Radiogenic leukemia revisited. | journal=Blood | year= 1987 | volume= 70 | issue= 4 | pages= 905-8 | pmid=3477299 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3477299 }} </ref><ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab</ref>Family history is not a risk factor and The chromosome mutation that leads to chronic myelogenous leukemia is believed to be acquired. | The most potent risk factor in the development of chronic myelogenous leukemia is [[ionizing radiation]]; for example, increased rates of CML were seen in people exposed to the atomic bombings of Hiroshima and Nagasaki. Other risk factors include older age, being male, [[formaldehyde]], [[obesity]], and [[smoking]].<ref name="pmid3477299">{{cite journal| author=Moloney WC| title=Radiogenic leukemia revisited. | journal=Blood | year= 1987 | volume= 70 | issue= 4 | pages= 905-8 | pmid=3477299 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3477299 }} </ref><ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab</ref>Family history is not a risk factor and The chromosome mutation that leads to chronic myelogenous leukemia is believed to be acquired.<ref name="pmid25814090">{{cite journal |vauthors=Höglund M, Sandin F, Simonsson B |title=Epidemiology of chronic myeloid leukaemia: an update |journal=Ann. Hematol. |volume=94 Suppl 2 |issue= |pages=S241–7 |date=April 2015 |pmid=25814090 |doi=10.1007/s00277-015-2314-2 |url=}}</ref> | ||
==Common Risk Factors== | ==Common Risk Factors== | ||
<ref name="pmid3477299">{{cite journal| author=Moloney WC| title=Radiogenic leukemia revisited. | journal=Blood | year= 1987 | volume= 70 | issue= 4 | pages= 905-8 | pmid=3477299 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3477299 }} </ref><ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab</ref><ref name="pmid25814090">{{cite journal |vauthors=Höglund M, Sandin F, Simonsson B |title=Epidemiology of chronic myeloid leukaemia: an update |journal=Ann. Hematol. |volume=94 Suppl 2 |issue= |pages=S241–7 |date=April 2015 |pmid=25814090 |doi=10.1007/s00277-015-2314-2 |url=}}</ref> | |||
*[[Ionizing radiation]] | *[[Ionizing radiation]] | ||
*[[Formaldehyde]] | *[[Formaldehyde]] | ||
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==Less common Risk Factors== | ==Less common Risk Factors== | ||
<ref name="pmid3477299">{{cite journal| author=Moloney WC| title=Radiogenic leukemia revisited. | journal=Blood | year= 1987 | volume= 70 | issue= 4 | pages= 905-8 | pmid=3477299 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3477299 }} </ref><ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab</ref><ref name="pmid25814090">{{cite journal |vauthors=Höglund M, Sandin F, Simonsson B |title=Epidemiology of chronic myeloid leukaemia: an update |journal=Ann. Hematol. |volume=94 Suppl 2 |issue= |pages=S241–7 |date=April 2015 |pmid=25814090 |doi=10.1007/s00277-015-2314-2 |url=}}</ref> | |||
*[[Radiotherapy]] | *[[Radiotherapy]] | ||
*[[Chemotherapy]] | *[[Chemotherapy]] | ||
Revision as of 14:40, 31 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
The most potent risk factor in the development of chronic myelogenous leukemia is ionizing radiation; for example, increased rates of CML were seen in people exposed to the atomic bombings of Hiroshima and Nagasaki. Other risk factors include older age, being male, formaldehyde, obesity, and smoking.[1][2]Family history is not a risk factor and The chromosome mutation that leads to chronic myelogenous leukemia is believed to be acquired.[3]
Common Risk Factors
- Ionizing radiation
- Formaldehyde
- Benzene
- Older age
- Being male
Less common Risk Factors
References
- ↑ 1.0 1.1 1.2 Moloney WC (1987). "Radiogenic leukemia revisited". Blood. 70 (4): 905–8. PMID 3477299.
- ↑ 2.0 2.1 2.2 Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab
- ↑ 3.0 3.1 3.2 Höglund M, Sandin F, Simonsson B (April 2015). "Epidemiology of chronic myeloid leukaemia: an update". Ann. Hematol. 94 Suppl 2: S241–7. doi:10.1007/s00277-015-2314-2. PMID 25814090.