Renal cell carcinoma causes: Difference between revisions
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|+ '''''Sporadic Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 |issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096 }} </ref>''''' | |+ '''''Sporadic Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 |issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096 }} </ref>''''' | ||
| | | style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Histologic Appearance''' || style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Incidence'''|| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Gene'''|| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Frequency''' | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''Conventional (Clear Cell)''' || 75 || VHL|| 60 % | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''Papillary''' || 12|| MET <br> TFE3|| 13 %<br> < 1 % | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''Chromophobe''' || 4 || || | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''Oncocytoma''' || 4 || || | ||
|- | |- | ||
|bgcolor="# | |bgcolor="#DCDCDC"|'''Collecting Duct''' || < 1 || || | ||
|- | |- | ||
|bgcolor="# | |bgcolor="#DCDCDC"|'''Unclassified''' || 3 - 5 || || | ||
|} | |} | ||
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup> | <sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup> | ||
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| | | style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Syndrome''' || style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Associated Gene'''|| style="background:#4479BA; color: #FFFFFF;" align="center" + |'''Common Histological Appearance''' | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''VHL Disease''' || VHL || Conventional (Clear Cell) | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''FCRC''' || Chromosome 3p translocation || Conventional (Clear Cell) | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''Hereditary Paraganglioma''' || SDHB || Conventional (Clear Cell) | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''HPRC''' || MET || Papillary | ||
|- | |- | ||
| bgcolor="# | | bgcolor="#DCDCDC"|'''HLRCC''' || FH || Papillary | ||
|- | |- | ||
|bgcolor="# | |bgcolor="#DCDCDC"|'''Birt-Hogg-Dube Syndrome''' || BHD || Chromophobe / Oncocytoma | ||
|} | |} | ||
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup> | <sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup> | ||
Revision as of 16:59, 31 July 2018
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Renal cell carcinoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Renal cell carcinoma causes On the Web |
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American Roentgen Ray Society Images of Renal cell carcinoma causes |
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Risk calculators and risk factors for Renal cell carcinoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]
Overview
The causes of renal cell carcinoma include von hippel-lindau (VHL), hereditary paragangliomas, leiomyomatosis, birt-hogg-dube syndrome, and several other genetic factors.
Causes
Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.
The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:
Sporadic Forms of Renal Cell Carcinoma
| Histologic Appearance | Incidence | Gene | Frequency |
| Conventional (Clear Cell) | 75 | VHL | 60 % |
| Papillary | 12 | MET TFE3 |
13 % < 1 % |
| Chromophobe | 4 | ||
| Oncocytoma | 4 | ||
| Collecting Duct | < 1 | ||
| Unclassified | 3 - 5 |
Hereditary Forms of Renal Cell Carcinoma
| Syndrome | Associated Gene | Common Histological Appearance |
| VHL Disease | VHL | Conventional (Clear Cell) |
| FCRC | Chromosome 3p translocation | Conventional (Clear Cell) |
| Hereditary Paraganglioma | SDHB | Conventional (Clear Cell) |
| HPRC | MET | Papillary |
| HLRCC | FH | Papillary |
| Birt-Hogg-Dube Syndrome | BHD | Chromophobe / Oncocytoma |
References
- ↑ 1.0 1.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.