Thrombotic thrombocytopenic purpura historical perspective: Difference between revisions
Created page with "__NOTOC__ {{Thrombotic thrombocytopenic purpura}} {{CMG}} ==Overview== ==Historical Perspective== TTP was initially described in a 16-year old girl by Dr Eli Moschcowitz of Ne..." |
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==Overview== | ==Overview== | ||
==Historical Perspective== | ==Historical Perspective== | ||
TTP | * In 1924, Eli Moschcowitz first describe TTP with a pentad of presentation.<ref>{{cite journal |author=Moschcowitz E |title=An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease. |journal=Proc NY Pathol Soc |volume=24 |pages=21-4 |year=1924}} Reprinted in ''Mt Sinai J Med'' 2003;70(5):322-5, PMID 14631522.</ref> | ||
* Moschcowitz ascribed the disease (incorrectly) to a toxic cause. Moschcowitz noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi. Since that time, the pathophysiology, etiology, and medical management of TTP has expanded. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 17:19, 6 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historical Perspective
- In 1924, Eli Moschcowitz first describe TTP with a pentad of presentation.[1]
- Moschcowitz ascribed the disease (incorrectly) to a toxic cause. Moschcowitz noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi. Since that time, the pathophysiology, etiology, and medical management of TTP has expanded.
References
- ↑ Moschcowitz E (1924). "An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease". Proc NY Pathol Soc. 24: 21–4. Reprinted in Mt Sinai J Med 2003;70(5):322-5, PMID 14631522.