Sandbox leucocytosis: Difference between revisions

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{| class="wikitable"
{| class="wikitable"
!
! colspan="3" |
!
!Differentiating Symptoms
!
!Differentiating physical exam findings
!
!Differentiating Labs
|-
|-
|Infection
| rowspan="3" |'''Physiological variation'''
| colspan="2" |Birth
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|Inflammation
| colspan="2" |Adult
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|Aspelenia
| colspan="2" |Pregnancy
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|-
|-
|Stress/Exercise
| rowspan="6" |'''Primary'''
| rowspan="4" |'''Congenital'''
|Heridatary neutrophilia
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|Chronic myeloid leukemia
|Chronic idiopathic neutrophilia
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|-
|Juvenile myelo-monocytic leukemia
|Down syndrome
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|-
|LAD
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| rowspan="2" |'''Acquired'''
|CML
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|Polycythemia vera
|Polycythemia Vera
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|Essential thrombocythemia
| rowspan="18" |'''Secondary'''
| rowspan="2" |'''Infection'''
|Acute
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|-
|Chronic myelomonocytic leukemia,
|Chronic
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|Chronic neutrophilic leukemia
| rowspan="4" |'''Connective tissue disorders'''
|RA
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|Mixed cryoglobulinemia
|JRA
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|Leukocyte adhesion deficiency
|IBD
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|Hereditary chronic neutrophilia
|Chronic hepatitis
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|Down syndrome
| rowspan="4" |'''Drug induced'''
|Steriod
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|-
|Lithium
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|Beta agonists
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|Cytokine administration
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| rowspan="2" |'''Marrow stimulation'''
|Hemolytic anemia
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|Immature thrombocytopenia
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|-
| colspan="2" |'''Post splenectomy'''
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| rowspan="5" |'''Metabolic'''
|Diabetic coma
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|Acidosis
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|Cryopyrin-associated periodic syndromes
|Thyroid strom
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|Acute Gout
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|Seizures
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|}
|}

Revision as of 23:53, 6 August 2018

  • Leukocytosis is defined as an elevated white blood cell (WBC) count greater than 11,000 per mm3 (11.0 × 109 per L).
  • The most common type of leukocytosis is neutrophilia.
    • Neutrophilia can be defined as an increase in the absolute number of mature neutrophils to greater than 7,000 per mm3 [7.0 × 109 per L].
Differentiating Symptoms Differentiating physical exam findings Differentiating Labs
Physiological variation Birth
Adult
Pregnancy
Primary Congenital Heridatary neutrophilia
Chronic idiopathic neutrophilia
Down syndrome
LAD
Acquired CML
Polycythemia Vera
Secondary Infection Acute
Chronic
Connective tissue disorders RA
JRA
IBD
Chronic hepatitis
Drug induced Steriod
Lithium
Beta agonists
Cytokine administration
Marrow stimulation Hemolytic anemia
Immature thrombocytopenia
Post splenectomy
Metabolic Diabetic coma
Acidosis
Thyroid strom
Acute Gout
Seizures