Angiomyolipoma other diagnostic studies: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
(Category)
Line 3: Line 3:
{{CMG}} {{AE}}{{Faizan}}
{{CMG}} {{AE}}{{Faizan}}
==Overview==
==Overview==
[[CT]] guided biopsy is diagnostic of angiomyolipoma.
[[CT]] guided biopsy is diagnostic of angiomyolipoma.However it is used to established the diagnosis,when imaging modalities fails to establish the diagnosis especially in cases of fat poor Angiomyolipoma that is difficult to distinguish from the [[Renal cell carcinoma]].


==Biopsy Findings==
==Biopsy Findings==
Biopsy findings of angiomyolipoma include:
Biopsy findings of angiomyolipoma include:
===Microscopic Features===
===Microscopic Features===
Microscopic features of angiomyolipoma are:<ref name=pmid15584043>{{Cite journal  | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref>
Microscopic features of angiomyolipoma are:<ref name="pmid15584043">{{Cite journal  | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref>
*[[Smooth muscle]]
*[[Smooth muscle]]
*Adipose tissue
*Adipose tissue
Line 26: Line 26:


===Cytologic===
===Cytologic===
Cytologic features of angiomyolipoma include:<ref name=pmid15584043>{{Cite journal  | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref>
Cytologic features of angiomyolipoma include:<ref name="pmid15584043">{{Cite journal  | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref>
*[[Nuclei]] - round/ovoid
*[[Nuclei]] - round/ovoid
*[[Chromatin]] - bland
*[[Chromatin]] - bland
Line 32: Line 32:
===Immunohistochemistry===
===Immunohistochemistry===
[[Immunohistochemistry]] markers of angiomyolipoma include:
[[Immunohistochemistry]] markers of angiomyolipoma include:
*Melanocytic markers positive<ref name=Ref_GUP324>{{Ref GUP|324}}</ref>
*Melanocytic markers positive<ref name="Ref_GUP324">{{Ref GUP|324}}</ref>
**HMB-45 positive in all cases (15/15)<ref name=pmid23932749>{{Cite journal  | last1 = Esheba | first1 = Gel S. | last2 = Esheba | first2 = Nel S. | title = Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study. | journal = J Egypt Natl Canc Inst | volume = 25 | issue = 3 | pages = 125-34 | month = Sep | year = 2013 | doi = 10.1016/j.jnci.2013.05.002 | PMID = 23932749 }}
**HMB-45 positive in all cases (15/15)<ref name="pmid23932749">{{Cite journal  | last1 = Esheba | first1 = Gel S. | last2 = Esheba | first2 = Nel S. | title = Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study. | journal = J Egypt Natl Canc Inst | volume = 25 | issue = 3 | pages = 125-34 | month = Sep | year = 2013 | doi = 10.1016/j.jnci.2013.05.002 | PMID = 23932749 }}
</ref>
</ref>
**Melan A positive in ~87% of cases (13/15)
**Melan A positive in ~87% of cases (13/15)
*Epithelial markers negative<ref name=Ref_GUP324>{{Ref GUP|324}}</ref>
*Epithelial markers negative<ref name="Ref_GUP324">{{Ref GUP|324}}</ref>
**EMA
**EMA
**AE1/AE3
**AE1/AE3
*SMA positive
*SMA positive
*CD117 positive/negative
*CD117 positive/negative
*Ki-67:<ref name=pmid18839327>{{Cite journal  | last1 = Ooi | first1 = SM. | last2 = Vivian | first2 = JB. | last3 = Cohen | first3 = RJ. | title = The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma. | journal = Int Urol Nephrol | volume = 41 | issue = 3 | pages = 559-65 | month =  | year = 2009 | doi = 10.1007/s11255-008-9473-1 | PMID = 18839327 }}</ref>
*Ki-67:<ref name="pmid18839327">{{Cite journal  | last1 = Ooi | first1 = SM. | last2 = Vivian | first2 = JB. | last3 = Cohen | first3 = RJ. | title = The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma. | journal = Int Urol Nephrol | volume = 41 | issue = 3 | pages = 559-65 | month =  | year = 2009 | doi = 10.1007/s11255-008-9473-1 | PMID = 18839327 }}</ref>
**Epithelioid variant of [[angiomyolipoma]] positive
**Epithelioid variant of [[angiomyolipoma]] positive
**Conventional angiomyolipoma negative
**Conventional angiomyolipoma negative

Revision as of 05:29, 9 August 2018

Angiomyolipoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Angiomyolipoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Angiomyolipoma other diagnostic studies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Angiomyolipoma other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Angiomyolipoma other diagnostic studies

CDC on Angiomyolipoma other diagnostic studies

Angiomyolipoma other diagnostic studies in the news

Blogs on Angiomyolipoma other diagnostic studies

Directions to Hospitals Treating Angiomyolipoma

Risk calculators and risk factors for Angiomyolipoma other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

CT guided biopsy is diagnostic of angiomyolipoma.However it is used to established the diagnosis,when imaging modalities fails to establish the diagnosis especially in cases of fat poor Angiomyolipoma that is difficult to distinguish from the Renal cell carcinoma.

Biopsy Findings

Biopsy findings of angiomyolipoma include:

Microscopic Features

Microscopic features of angiomyolipoma are:[1]

  • Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.[2]

    Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.[2]

  • Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.[2]

    Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.[2]

  • Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.[2]

    Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.[2]

  • Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. HMB-45 immunostain.[2]

    Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. HMB-45 immunostain.[2]

Cytologic

Cytologic features of angiomyolipoma include:[1]

Immunohistochemistry

Immunohistochemistry markers of angiomyolipoma include:

  • Melanocytic markers positive[3]
    • HMB-45 positive in all cases (15/15)[4]
    • Melan A positive in ~87% of cases (13/15)
  • Epithelial markers negative[3]
    • EMA
    • AE1/AE3
  • SMA positive
  • CD117 positive/negative
  • Ki-67:[5]
    • Epithelioid variant of angiomyolipoma positive
    • Conventional angiomyolipoma negative

References

  1. ↑ 1.0 1.1 Crapanzano, JP. (2005). "Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases". Diagn Cytopathol. 32 (1): 53–7. doi:10.1002/dc.20179. PMID 15584043. Unknown parameter |month= ignored (help)
  2. ↑ 2.0 2.1 2.2 2.3 http://librepathology.org/wiki/index.php/Angiomyolipoma
  3. ↑ 3.0 3.1 Template:Ref GUP
  4. ↑ Esheba, Gel S.; Esheba, Nel S. (2013). "Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study". J Egypt Natl Canc Inst. 25 (3): 125–34. doi:10.1016/j.jnci.2013.05.002. PMID 23932749. Unknown parameter |month= ignored (help)
  5. ↑ Ooi, SM.; Vivian, JB.; Cohen, RJ. (2009). "The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma". Int Urol Nephrol. 41 (3): 559–65. doi:10.1007/s11255-008-9473-1. PMID 18839327.

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Angiomyolipoma_other_diagnostic_studies&oldid=1489453"