Thrombocytopenia history and symptoms: Difference between revisions
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* [[Blood transfusion|Transfusions]] | * [[Blood transfusion|Transfusions]] | ||
* [[Organ transplant]] | * [[Organ transplant]] | ||
* Medications ([[aspirin]], [[Non-steroidal anti-inflammatory drug|NSAID]]<nowiki/>s, [[heparin]], [[Low molecular weight heparin|LMWH]], etc.)/ [[Herb|herbs]]/ chemicals/ [[Radiation (medicine)|radiation]] | *<nowiki/>Medications ([[aspirin]], [[Non-steroidal anti-inflammatory drug|NSAID]]<nowiki/>s, [[heparin]], [[Low molecular weight heparin|LMWH]], etc.)/ [[Herb|herbs]]/ chemicals/ [[Radiation (medicine)|radiation]] | ||
* Family history of bleeding disorders and/or [[thrombocytopenia]]. ('''Note:''' Negative family history does not rule out the possibility of genetic [[Etiology|etiologies]] because some individuals with familial platelet disorders remain undiagnosed well into adulthood.) | * Family history of bleeding <nowiki/>disorders and/or [[thrombocytopenia]]. ('''Note:''' Negative family history does not rule out the possibility of genetic [[Etiology|etiologies]] because some individuals with familial platelet disorders remain undiagnosed well into adulthood.) | ||
* Dietary habits (eg, vegetarianism) | * Dietary habits (eg, vegetarianism) | ||
* High-risk behaviors ([[Human Immunodeficiency Virus (HIV)|HIV]], [[hepatitis]]) | * High-risk behaviors ([[Human Immunodeficiency Virus (HIV)|HIV]], [[hepatitis]]) | ||
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==Symptoms== | ==Symptoms== | ||
Thrombocytopenia usually has no symptoms and is picked up on a routine full blood count (or complete blood count). Symptomatic patients may experience: | |||
* easy bruising | |||
* bleeding symptoms (eg, [[Petechia|petechiae]], [[purpura]], [[Ecchymosis|ecchymoses]], [[epistaxis]], [[Gingiva|gingival]] bleeding, [[hematemesis]], [[melena]], [[menorrhagia]]) | |||
* malaise, fatigue and general weakness | |||
Other symptoms associated with the specific underlying cause of thrombocytopenia may also be present. | |||
==References== | ==References== | ||
Revision as of 19:20, 17 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Farbod Zahedi Tajrishi, M.D. [2]
Overview
History
A thorough history is essential to an effective evaluation of thrombocytopenia. While some of the conditions leading to thrombocytopenia can be immediately diagnosed, others may require specific or repeated questioning. In addition to a well-investigated present illness, a precise past medical history can help a great deal to identify the cause of thrombocytopenia. The history should include questions about:[1][2][3]
- Bleeding (eg, petechiae, ecchymoses, epistaxis, gingival bleeding, hematemesis, melena, menorrhagia)
- Other symptpms such as fever, rashes, pain (eg, in bone), headache, or vision changes
- Recent travel (dengue fever, malaria, rickettsial infections, tick bite, leptospirosis, meningococcemia, Hantavirus, Ebola, Lassa fever
- Recent hospitalizations/ immunizations
- Any previous illnesses (esp. hematologic and rheumatologic) and recent infections, malignancies (eg, myelodysplastic syndrome, leukemia, lymphoma, aplastic anemia)
- Pregnancy
- Transfusions
- Organ transplant
- Medications (aspirin, NSAIDs, heparin, LMWH, etc.)/ herbs/ chemicals/ radiation
- Family history of bleeding disorders and/or thrombocytopenia. (Note: Negative family history does not rule out the possibility of genetic etiologies because some individuals with familial platelet disorders remain undiagnosed well into adulthood.)
- Dietary habits (eg, vegetarianism)
- High-risk behaviors (HIV, hepatitis)
- Alcohol/ drug use
Symptoms
Thrombocytopenia usually has no symptoms and is picked up on a routine full blood count (or complete blood count). Symptomatic patients may experience:
- easy bruising
- bleeding symptoms (eg, petechiae, purpura, ecchymoses, epistaxis, gingival bleeding, hematemesis, melena, menorrhagia)
- malaise, fatigue and general weakness
Other symptoms associated with the specific underlying cause of thrombocytopenia may also be present.
References
- ↑ Greenberg EM, Kaled ES (2013). "Thrombocytopenia". Crit Care Nurs Clin North Am. 25 (4): 427–34, v. doi:10.1016/j.ccell.2013.08.003. PMID 24267279.
- ↑ Patel U, Gandhi G, Friedman S, Niranjan S (2004). "Thrombocytopenia in malaria". J Natl Med Assoc. 96 (9): 1212–4. PMC 2568454. PMID 15481750.
- ↑ West KA, Anderson DR, McAlister VC, Hewlett TJ, Belitsky P, Smith JW; et al. (1999). "Alloimmune thrombocytopenia after organ transplantation". N Engl J Med. 341 (20): 1504–7. doi:10.1056/NEJM199911113412004. PMID 10559451.