Macrocytic anemia historical perspective: Difference between revisions

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Revision as of 20:32, 20 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal.
Increase in bone marrow cellls was noted by Cohnheim in 1876.

The association between megaloblastic(pernicious) anemia and spinal cord lesions was made in 1887 by Lichtheim.
Subacute combined degeneration of spinal cord was coined by Russell et al in 1900.
In 1908, Cabot was the first to discover the association between megaloblastic anemia and the development of numbness and tingling of extremities.
In 1923, Minot and Murphy started a diet for people with anemia which had animal sources like liver, muscle meat, leafy vegetables, eggs and milk. they discovered rises in cell count and hemoglobin levels.
In 1934, Whipple, Minot and Murphy were awarded with Nobel prize for medicine and physiology for saving the lives of anemic people with dietary measures.

There have been several outbreaks of [disease name], which are summarized below:

In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

The following are a few famous cases of disease name:

@@ Line 9: / Line 9: @@
 ===Discovery===
-*[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
+*Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal.
+*Increase in bone marrow cellls was noted by Cohnheim in 1876.
-*The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
+*The association between megaloblastic(pernicious) anemia  and spinal cord lesions was made in 1887 by Lichtheim.
-*In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
+*[[Subacute combined degeneration of spinal cord]] was  coined by Russell et al in 1900.
-*In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
+*In 1908, Cabot was the first to discover the association between  megaloblastic anemia  and the development of [[numbness]] and [[tingling]] of extremities.
+*In 1923, Minot and Murphy started a diet for people with anemia which had animal sources like liver, muscle meat, leafy vegetables, eggs and milk. they discovered rises in cell count and [[hemoglobin]] levels.
+*In 1934, Whipple, Minot and Murphy were awarded with Nobel prize for medicine and physiology for saving the lives of anemic people with dietary measures.
 ==Outbreaks==