Thrombotic thrombocytopenic purpura diagnostic study of choice: Difference between revisions
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== Overview == | == Overview == | ||
== Study of choice == | == Study of choice == | ||
* '''ADAMTS13 test:''' | * '''ADAMTS13 test:''' | ||
'''Studies that may be considered for diagnosis of the suspected cases of TTP:''' | '''Studies that may be considered for diagnosis of the suspected cases of TTP:''' | ||
* Complete blood count (CBC) with platelet count | * Complete blood count (CBC) with platelet count | ||
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{{#Widget:PLASMIC score}} | {{#Widget:PLASMIC score}} | ||
<br> | <br> | ||
'''<big>Risk of ADAMPTS13 deficiency</big>''' '''<big>in adults with suspected TTP</big>''' | '''<big>Risk of ADAMPTS13 deficiency</big>''' '''<big>in adults with suspected TTP</big>''' '''<big>:</big>''' | ||
* '''Low-risk''' = 0 to 4 points | * '''Low-risk''' = 0 to 4 points | ||
* '''Intermediate risk''' = 5 points | * '''Intermediate risk''' = 5 points | ||
Revision as of 22:19, 24 August 2018
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Thrombotic thrombocytopenic purpura Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2]
Overview
Study of choice
- ADAMTS13 test:
Studies that may be considered for diagnosis of the suspected cases of TTP:
- Complete blood count (CBC) with platelet count
- Review of the peripheral blood smear
- Serum electrolytes and creatinine
- Serum lactate dehydrogenase (LDH)
- Serum bilirubin level
- Coagulation testing ( PT, aPTT, fibrinogen, D-dimer)
- Serum haptoglobin level
- Direct antiglobulin (Coombs) test (DAT)
- ADAMTS13 activity and inhibitor testing
- Stool exam
PLASMIC score
Risk of ADAMPTS13 deficiency in adults with suspected TTP :
- Low-risk = 0 to 4 points
- Intermediate risk = 5 points
- High-risk = 6 to 7 points